Thyroid Cancer

Source: news.yahoo.com --- 9 days ago
HealthDay - FRIDAY, Aug. 29 (HealthDay News) -- Some Japanese survivors of the World War II atomic bomb blasts in Hiroshima and Nagasaki experienced key genetic changes that may have sparked the onset of a form of Thyroid Cancer, new research indicates. ...

Source: thyroid.about.com --- 15 days ago
A look at famous people and celebrities with Thyroid conditions including hypothyroidism, hyperthyroidism, Hashimoto's disease, Graves' disease, nodules, and Thyroid Cancer. Celebrities profiled include George Bush, Barbara Bush, Linda Ronstadt, Catherine Bell, Oprah Winfrey, Rod Stewart, Joe Piscopo, Roger Ebert, Tipper Gore, Kelly Osbourne, Gail Devers, Kim Alexis, and Kim Cattrall. ...

Source: www.moreover.com --- 8 days ago
Beyond PTEN: Alternate genes linked to breast, Thyroid and kidney Cancer predisposition (NewsRx. ...

Source: www.ncbi.nlm.nih.gov --- 22 days ago
Predictors of level V metastasis in well-differentiated Thyroid Cancer. Head Neck. 2008 Aug 14; Authors: Kupferman ME, Weinstock YE, Santillan AA, Mishra A, Roberts D, Clayman GL, Weber RS BACKGROUND.: Cervical lymphadenectomy is frequently performed in patients with lateral cervical lymph node metastases to improve regional control of disease. However, there is no consensus regarding the appropriate levels of the neck that need to be dissected. Treatment options that have been advocated include the modified radical neck dissection, limited neck dissections, and selective nodal excisions. In particular, the routine dissection of level V remains controversial due to the attendant morbidity to the spinal accessory nerve. To identify clinical and pathological predictors of cervical node metastases to level V in differentiated Thyroid carcinoma, we reviewed our experience at The University of Texas M. D. Anderson Cancer Center for the management of metastatic well-differentiated Thyroid Cancer. METHODS.: We retrospectively analyzed 70 patients who underwent thyroidectomy and neck dissection for well-differentiated Thyroid Cancer at M. D. Anderson Cancer Center. RESULTS.: In our series, 53% of neck specimens harbored metastatic Thyroid carcinoma at level V. Additionally, 13 level V contralateral neck dissections were performed, and 57% were found positive for metastases. The presence of ipsilateral level V metastases was significantly asso ...

Source: www.ncbi.nlm.nih.gov --- 24 days ago
Related Articles Oncolytic Vaccinia Virotherapy of Anaplastic Thyroid Cancer In Vivo. J Clin Endocrinol Metab. 2008 Aug 12; Authors: Lin SF, Price DL, Chen CH, Brader P, Li S, Gonzalez L, Zhang Q, Yu YA, Chen N, Szalay AA, Fong Y, Wong RJ Context: Anaplastic Thyroid carcinoma is a fatal disease with a median survival of only 6 months. Novel therapies are needed to improve dismal outcomes. Objective: A mutated, replication-competent, vaccinia virus (GLV-1h68) has oncolytic effects on human anaplastic Thyroid carcinoma cell lines in vitro. We assessed the utility of GLV-1h68 in treating anaplastic Thyroid Cancer in vivo. Design: Athymic nude mice with xenograft flank tumors of human anaplastic Thyroid carcinomas (8505C and DRO90-1) were treated with a single intratumoral injection of GLV-1h68 at low dose (5x10(5) pfu), high dose (5x10(6) pfu), or PBS. Virus-mediated marker gene expression (luciferase, GFP and beta-galactosidase), viral biodistribution, and flank tumor volumes were measured. Results: Luciferase expression was detected 2 days after injection. Continuous viral replication within tumors was reflected by increasing luciferase activity to day 9. At day 10, tumor viral recovery was increased >50-fold as compared to the injected dose, and minimal virus was recovered from the lung, liver, brain, heart, spleen, and kidneys. High dose virus directly injected into normal tissues was undetectable at day 10. The mean volume of contro ...

Source: www.ncbi.nlm.nih.gov --- 20 days ago
Related Articles Same-day ultrasound guidance in reoperations for locally recurrent papillary Thyroid Cancer. Surgery. 2007 Dec;142(6):973-5 Authors: Solorzano CC, Evans DB PMID: 18063084 [PubMed - indexed for MEDLINE] ...

Source: www.moreover.com --- 9 days ago
FRIDAY, Aug. 29 (HealthDay News) -- Some Japanese survivors of the World War II atomic bomb blasts in Hiroshima and Nagasaki experienced key genetic changes that may have sparked the onset of a form of Thyroid Cancer, new research indicates. ...

Source: www.moreover.com --- 8 days ago
issue of Cancer Research, a journal of the American Association for Cancer Research, the scientists report that subjects who lived close to the blast sites, were comparably young at the time, and developed the Cancer quickly once they reached ...

Source: www.moreover.com --- 31 days ago
-- A new discovery may lead to more effective screening and treatment for patients with a difficult to recognise syndrome characterised by tumour-like growths and a high risk of developing specific cancers. ...

Source: www.ncbi.nlm.nih.gov --- 4 days ago
Related Articles Phosphoinositide-3-kinase (PI3K) Inhibition Induces Sodium/Iodide Symporter Expression (NIS) in Rat Thyroid Cells and Human Papillary Thyroid Cancer Cells. J Endocrinol. 2008 Sep 1; Authors: Kogai T, Sajid-Crockett S, Newmarch L, Liu YY, Brent G Thyrotropin (TSH) stimulation of sodium iodide symporter (NIS) expression in Thyroid Cancer promotes radioiodine uptake and is required to deliver an effective treatment dose. Activation of the insulin/PI3K (phosphoinositide-3-kinase) signaling pathway in TSH-stimulated Thyroid cells reduces NIS expression at the transcriptional level. We, therefore, investigated the effects of PI3K pathway inhibition on iodide uptake and NIS expression in rat Thyroid cell lines and human papillary Thyroid Cancer cells. A PI3K inhibitor, LY294002, significantly enhanced iodide uptake in two rat Thyroid cell lines, FRTL-5 and PCCL3. The induction of NIS mRNA by LY294002 occurred 6 hours after treatment, and was abolished by a translation inhibitor, cycloheximide. Expression of the transcription factor, Pax-8, which stimulates NIS expression, was significantly increased in PCCL3 cells after LY294002 treatment. Removal of insulin abrogated the stimulatory effects of LY294002 on NIS mRNA and protein expression, but not on iodide uptake. These findings suggest that PI3K pathway inhibition results in post-translational stimulation of NIS. Inhibition of the PI3K pathway also significantly increased io ...

Source: www.ncbi.nlm.nih.gov --- 2 days ago
Related Articles The additive clinical value of combined thyroglobulin and antithyroglobulin antibody measurements to define persistent and recurrent disease in patients with differentiated Thyroid Cancer. Nucl Med Commun. 2008 Oct;29(10):880-4 Authors: Aras G, Gültekin SS, Küçük NO AIM: To evaluate retrospectively the additive clinical value of combined thyroglobulin (Tg) and antithyroglobulin antibody (TgAb) measurements to define recurrent and persistent disease in patients with differentiated Thyroid Cancer. MATERIALS/METHODS: 181 patients with differentiated Thyroid Cancer were included in the study. The nonstable disease group (recurrent and persistent disease) had 61 patients with 24-36 months follow-up period. The stable disease group (without recurrence or persistence) had 120 patients with 21-28 months follow-up period. We compared Tg and combined Tg-TgAb levels on the sixth month after the ablation between two groups. RESULTS: Optimal threshold values for Tg, TgAb measurements were calculated statistically as 4.45 ng/ml and 27.8 IU/ml. Optimal sensitivity and specificity for 4.45 ng/ml Tg levels were 52.5 and 91.7%. We also evaluated different Tg threshold values. We found sensitivity was 54.2% and specificity 86.7% for 2 ng/ml and sensitivity was 40.7% and specificity 96.7% for 10 ng/ml Tg levels. By the odds ratio (OR) rule, the obtained sensitivity and specificity were 68.3 and 90% (if Tg>10 ng/ml or TgAb>27.8 IU/ml), 78. ...

Source: www.ksl.com --- 7 days ago
Japanese researchers have identified a cause-and-effect link between radiation from atomic bomb blasts and adult-onset Thyroid Cancer. ...

Source: www.sciencedaily.com --- 9 days ago
Radiation from the atomic bomb blasts in Hiroshima and Nagasaki, Japan, in 1945, likely rearranged chromosomes in some survivors who later developed papillary Thyroid Cancer as adults, according to Japanese researchers. ...

Source: www.moreover.com --- 22 days ago
NewsRX Aug 16 2008 10:43AM GMT ...

Source: www.medicalnewstoday.com --- 30 days ago
A new discovery may lead to more effective screening and treatment for patients with a difficult to recognize syndrome characterized by tumor-like growths and a high risk of developing specific cancers. The research, published by Cell Press in the August 7 issue of the American Journal of Human Genetics, is the first in over thirteen years to identify an alternate susceptibility gene for Cowden syndrome (CS) and related disorders. ...

Source: www.healthboards.com --- 34 days ago
Hello i am a 20 year old male, when i was 18 i was diagnosed with papillary carcinoma Thyroid Cancer, ive had my Thyroid removed and have been on medication to regulate everything since. Last week when visiting with my Endocrinologist I read in my... ...

Source: www.medpagetoday.com --- 9 days ago
HIROSHIMA, Japan (MedPage Today) -- Radiation from atom bomb blasts in Hiroshima and Nagasaki in 1945 may have rearranged genes in some young survivors who developed papillary Thyroid Cancer as adults, a study found. ...

Source: www.indiaenews.com --- 9 days ago
Radiation from the atomic bomb detonations in Hiroshima and Nagasaki in 1945 possibly rearranged chromosomes in some survivors who later developed papillary Thyroid Cancer as adults, according to a research. ...

Source: www.news-medical.net --- 6 days ago
Radiation from the atomic bomb blasts in Hiroshima and Nagasaki, Japan, in 1945, likely rearranged chromosomes in some survivors who later developed papillary Thyroid Cancer as adults, according to Japanese researchers. ...