Therapeutic

Source: www.rediff.com --- 5 days ago
Luc Montagnier, 76, said a treatment could be possible in the future with a 'Therapeutic' rather than preventive vaccine for which results might be published in three or four years if financial backing is forthcoming. ...

Source: www.ncbi.nlm.nih.gov --- 3 hours ago
Related Articles Importance of Schedule of Administration in the Therapeutic Efficacy of Guanosine: Early Intervention After Injury Enhances Glutamate Uptake in Model of Hypoxia-ischemia. J Mol Neurosci. 2008 Oct 10; Authors: Moretto MB, Boff B, Lavinsky D, Netto CA, Rocha JB, Souza DO, Wofchuk ST Perinatal cerebral hypoxia-ischemia (HI) is an important cause of mortality and neurological disabilities such as cerebral palsy, epilepsy, and mental retardation. The potential for neuroprotection in HI can be achieved mainly during the recovery period. In previous work, we demonstrated that guanosine (Guo) prevented the decrease of glutamate uptake by hippocampal slices of neonatal rats exposed to a hypoxic-ischemic (HI) insult in vivo when administrated before and after insult. In the present study, we compared the effect of Guo administration only after HI using various protocols. When compared with the control, a decrease of [(3)H] glutamate uptake was avoided only when three doses of Guo were administered immediately, 24 h and 48 h after insult, or at 3 h, 24 h, and 48 h after injury or at 6 h, 24 h, and 48 h after HI. These findings indicate that early Guo administration (until 6 h) after HI, in three doses may enhance glutamate uptake into brain slices after hypoxia/ischemia, probably resulting in decreased excitotoxicity. PMID: 18846436 [PubMed - as supplied by publisher] ...

Source: www.ncbi.nlm.nih.gov --- 4 days ago
Related Articles [Changing neurology--from diagnostic to Therapeutic discipline] Lakartidningen. 2008 Sep 3-9;105(36):2413-6 Authors: Smits A, Andsberg G, Andersen PM, Andersson M, Fredrikson S, Gunnarsson M, Kumlien E, Lycke J, Jensen SM, Remahl IN, Nyholm D PMID: 18831452 [PubMed - indexed for MEDLINE] ...

Source: www.ncbi.nlm.nih.gov --- 7 days ago
Related Articles Diffuse skin spread of HIV-associated visceral leishmaniasis: cumbersome diagnostic and Therapeutic issues. G Ital Dermatol Venereol. 2008 Oct;143(5):339-46 Authors: Manfredi R, Passarini B, D'Antuono A, Misciali C, Marinacci G, Calza L An infrequent and atypical case report of HIV-associated visceral leishmaniasis complicated by a diffuse, aspecific maculo-papular cutaneous involvement was characterized by a prolonged course, and a lack of response to repeated attack/maintenance cycles performed with liposomal amphotericin B, despite a satisfactory immune response maintained thanks to a concurrent, potent combination antiretroviral treatment. Only a very prolonged administration of the older i.v. pentamidine isethionate together with oral paromomycin led to a slow, but complete cure of both visceral leishmaniasis and its related skin dissemination, in absence of adverse events and long-term disease relapses. PMID: 18833075 [PubMed - in process] ...

Source: www.ncbi.nlm.nih.gov --- 7 days ago
Related Articles Allosteric modulators of the human calcium-sensing receptor: structures, sites of action, and Therapeutic potentials. Endocr Metab Immune Disord Drug Targets. 2008 Sep;8(3):192-7 Authors: Hu J The human extracellular Ca(2+)-sensing receptor (CaR) plays a key role in the regulation of serum calcium and parathyroid hormone. This large dimeric receptor consists of domains with topologically distinctive orthosteric and allosteric sites. Positive allosteric modulators of the CaR, which increase CaR activation and thereby decrease secretion of parathyroid hormone, are potential for the treatment of primary and secondary hyperparathyroidism. Conversely, negative allosteric modulators of the CaR, which decrease the receptor activation and thereby stimulate endogenous parathyroid hormone secretion, are potential for the treatment of osteoporosis and autosomal dominant hypocalcemia. Significant progress has been made in recent years in screening for allosteric modulators selectively targeting the CaR and identification of receptor residues important for allosteric modulation. PMID: 18782015 [PubMed - indexed for MEDLINE] ...

Source: www.ncbi.nlm.nih.gov --- 6 days ago
Related Articles Conclusions of the expert panel: importance of erlotinib as a second-line Therapeutic option. BMC Proc. 2008;2 Suppl 2:S4 Authors: Castagnari A ABSTRACT : During the Experts Meeting on Lung Cancer, participants emphasized the usefulness of erlotinib as second-line therapy for lung cancer. They noted that, although there are no comparative studies, erlotinib could be as effective as docetaxel and pemetrexed in second-line therapy. Regarding the toxicity profile of each of these drugs - one of the key issues considered in the meeting - specialists pointed out how important it is to clearly identify existing differences in this issue. Each drug has different degrees of toxicity, and this information is crucial at the time of choosing the Therapeutic regimen. Erlotinib treatment could be an effective option for second-line therapy. PMID: 18831720 [PubMed - in process] ...

Source: www.moreover.com --- 7 days ago
To determine whether Helicobacter pylori eradication is an effective treatment for Australian patients with chronic immune thrombocytopenic purpura (ITP). Design, setting and patients: Retrospective analysis of clinical records of a consecutive series ...

Source: www.ncbi.nlm.nih.gov --- 5 days ago
Related Articles Computed tomography perfusion in evaluating the Therapeutic effect of transarterial chemoembolization for hepatocellular carcinoma. World J Gastroenterol. 2008 Oct 7;14(37):5738-43 Authors: Chen G, Ma DQ, He W, Zhang BF, Zhao LQ AIM: To prospectively assess the changes in parameters of computed tomography (CT) perfusion pre- and post-transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) in different treatment response groups, and to correlate the changes with various responses of HCC to TACE. METHODS: Thirty-nine HCC patients underwent CT perfusion examinations pre-(1 d before TACE) and post-treatment (4 wk after TACE). The response evaluation criteria for solid tumors (RECIST) were referred to when treatment responses were distributed. Wilcoxon-signed ranks test was used to compare the differences in CT perfusion parameters pre- and post-TACE for different response groups. RESULTS: Only one case had treatment response to CR and the CT perfusion maps of post-treatment lesion displayed complete absence of signals. In the PR treatment response group, hepatic artery perfusion (HAP), hepatic arterial fracture (HAF) and hepatic blood volume (HBV) of viable tumors post-TACE were reduced compared with pre-TACE (P = 0.001, 0.030 and 0.001, respectively). In the SD group, all CT perfusion parameters were not significantly different pre- and post-TACE. In the PD group, HAP, HAF, portal vein perfusion (PVP) and ...

Source: www.ncbi.nlm.nih.gov --- 3 days ago
Related Articles [Fournier's gangrene in an HIV-positive patient. Therapeutic options] Chir Ital. 2008 Jul-Aug;60(4):607-15 Authors: Licheri S, Erdas E, Pisano G, Garau A, Barbarossa M, Tusconi A, Pomata M Fournier's gangrene is a life-threatening necrotising infection of the perineal and genital regions. The case presented here refers to an HIV-positive 42-year-old man, admitted in emergency to our department with clinical signs and symptoms of sepsis related to gangrene of the perineum and scrotum. An early wide surgical necrosectomy was performed under epidural anaesthesia. Treatment was completed by intensive care, broad-spectrum antibiotics and hyperbaric oxygen therapy. The wound was managed with advanced dressing (AQUACEL Hydrofiber) until complete healing was obtained, and the scrotum was reconstructed with skin flaps. The disease did not involve the testes, spermatic cord or anorectal canal. The satisfactory aesthetic and functional outcome prompts the authors to stress a number of features of the Therapeutic approach adopted: (i) the advantages of epidural anaesthesia with an indwelling catheter that allows further necrosectomy and wound dressing to be performed totally painlessly; (ii) the possibility of avoiding faecal diversion by means of synthetic opioid drugs which are useful to reduce the frequency of defecation; and (iii) the positive impact of advanced dressing on the wound healing process in relation to patient sati ...

Source: www.ncbi.nlm.nih.gov --- 1 day ago
CTLA4Ig and the Therapeutic potencial of T cell co-stimulation blockade. Acta Reumatol Port. 2008 Jul-Sep;33(3):267-276 Authors: Graca L It is now generally accepted that CD4 T cells are critical players in the initiation of adaptive immune responses by contributing to the terminal differentiation of effector B cells or CD8 T cells. It is therefore not surprising that CD4 T cell activation is tightly controlled through the concerted action of a large number of molecular interactions. Activation requires not only the recognition of the appropriate antigen within a MHC molecule by the T cell receptor TCR but also the delivery of co-stimulatory signals by the antigen presenting cell APC . As a consequence Therapeutic modulation of co-stimulatory molecules for instance with CTLA4Ig can lead to interference with T cell activation and consequently abrogation of pro-inflammatory manifestations mediated by cell types influenced by CD4 T cells such as B cells CD8 T cells or macrophages. This type of observations provided the rationale for the use of co-stimulatory blockade in autoimmunity and other immunopathology characterized by inappropriate immune activation such as rheumatoid arthritis RA . Several studies have also suggested that besides the non-specific anti-inflammatory effects co-stimulation blockade may in certain conditions promote the induction of long term immune tolerance. PMID: 18846007 [PubMed - as supplied by publisher] ...

Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles MAPK signalling in cardiovascular health and disease: molecular mechanisms and Therapeutic targets. Clin Sci (Lond). 2008 Oct;115(7):203-18 Authors: Muslin AJ Intracellular MAPK (mitogen-activated protein kinase) signalling cascades probably play an important role in the pathogenesis of cardiac and vascular disease. A substantial amount of basic science research has defined many of the details of MAPK pathway organization and activation, but the role of individual signalling proteins in the pathogenesis of various cardiovascular diseases is still being elucidated. In the present review, the role of the MAPKs ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase) and p38 MAPK in cardiac hypertrophy, cardiac remodelling after myocardial infarction, atherosclerosis and vascular restenosis will be examined, with attention paid to genetically modified murine model systems and to the use of pharmacological inhibitors of protein kinases. Despite the complexities of this field of research, attractive targets for pharmacological therapy are emerging. PMID: 18752467 [PubMed - indexed for MEDLINE] ...

Source: www.prweb.com --- 6 days ago
Billions are spent annually on the treatment of pain but often with unsatisfactory results. In his latest instructional DVD, internationally recognized Thai massage teacher Chuck Duff emphasizes the fact that many pain issues are a result of physical and energetic imbalances within the body and that traditional Thai Massage remains one of our most powerful tools in the treatment of pain and dysfunction. A complete, 2.5 hour Therapeutic Thai massage sequence is taught in this beautifully produced title, Therapeutic Thai Fundamentals with Chuck Duff (138 minutes, $49.95 SRP). (PRWeb Oct 7, 2008) Read the full story at http://www.prweb.com/releases/thai_massage/dvd/prweb1171684.htm ...

Source: www.medscape.com --- 4 days ago
A review offers Therapeutic options for treating atopic dermatitis in children and discusses the differences between topical corticosteroids and topical calcineurin inhibitors. Medscape Medical News ...

Source: www.moreover.com --- 5 days ago
Calando Pharmaceuticals, a majority-owned subsidiary of Arrowhead Research Corporation, announced today that pre-clinical development of a second siRNA oncology Therapeutic, CALAA-02, is underway. ...

Source: www.medicalnewstoday.com --- 4 days ago
A study released at the 73rd Annual Scientific Meeting of the American College of Gastroenterology in Orlando found that a new Therapeutic treatment, when delivered endoscopically and used in combination with chemotherapy and radiation therapy, improved survival rates in patients with locally advanced esophageal cancer. Cancer of the esophagus often has a poor survival rate. Dr. ...

Source: pubs.acs.org --- 5 days ago
Kim D. Vandegriff, Ashok Malavalli, Gnel M. Mkrtchyan, Stephanie N. Spann, Dale A. Baker, and Robert M. Winslow Web Release Date: Tue, 7 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/bc8002666 ...

Source: pubs.acs.org --- 1 day ago
Jasbir Singh, Michael Salcius, Shin-Wu Liu, Bart L. Staker, Rama Mishra, John Thurmond, Gregory Michaud, Dawn R. Mattoon, John Printen, Jeffery Christensen, Jon Mar Bjornsson, Brian A. Pollok, Megerditch Kiledjian, Lance Stewart, Jill Jarecki, and Mark E. Gurney Web Release Date: Wed, 8 Oct 2008 00:00:00 EDT (Articles) DOI: 10.1021/cb800120t ...

Source: www.medicalnewstoday.com --- 6 days ago
StemCells, Inc. (Nasdaq:STEM) announced that it has been awarded a $305,000 grant from the National Institute of Diabetes and Digestive and Kidney Diseases to research and develop a potential cell-based Therapeutic for liver disease arising from infection by the hepatitis C virus (HCV). Hepatitis C is a global health challenge, with approximately 170 million people affected worldwide and an estimated three million new infections each year. ...

Source: www.moreover.com --- 6 days ago
Telegraph Oct 7 2008 5:15AM GMT ...

Source: www.medpagetoday.com --- 6 days ago
ORLANDO (MedPage Today) -- A preview of new guidelines for irritable bowel syndrome and results of the first trial of biologics for treatment of postoperative inflammatory bowel disease were among the highlights of the American College of Gastroenterology meeting today. ...