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Source: www.ncbi.nlm.nih.gov --- 9 hours ago
Related Articles TNK2 preserves epidermal growth factor receptor expression on the cell Surface and enhances migration and invasion of human breast cancer cells. Breast Cancer Res. 2008;10(2):R36 Authors: Howlin J, Rosenkvist J, Andersson T INTRODUCTION: Amplification of the TNK2 gene in primary tumours correlates with poor prognosis. In accordance, TNK2 overexpression was shown to promote invasion of cancer cells--but the mechanism by which TNK2 mediates these effects is unresolved. TNK2 was suggested to regulate Cdc42-driven migration by activation of breast cancer antioestrogen resistance 1 (BCAR1); however, distinct from this effect is evidence for a role of TNK2 in the regulation of epidermal growth factor receptor (EGFR) endocytosis and degradation. In the present study we sought to investigate whether negative targeting of TNK2 by siRNA could be used to inhibit cancer cell invasion, to establish the contribution of its effect on the EGFR and to consequently attempt to resolve the issue of TNK2's mechanism of action. METHODS: We used siRNA to knockdown expression of TNK2 and its proposed effector BCAR1 in order to analyse the effect of this knockdown on cancer cell behaviour in vitro. We examined morphological changes using phase-contrast microscopy and immunohistochemistry. Functional parameters examined included apoptosis, proliferation, migration and invasion. We also performed flow cytometry analysis to examine EGFR cell sur ... Source: www.ncbi.nlm.nih.gov --- 19 hours ago
Related Articles Flow induced by acoustic streaming on Surface-acoustic-wave devices and its application in biofouling removal: A computational study and comparisons to experiment. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Jun;77(6 Pt 2):066308 Authors: Sankaranarayanan SK, Cular S, Bhethanabotla VR, Joseph B All transducers used in biological sensing suffer from fouling resulting from nonspecific binding of protein molecules to the device Surface. The acoustic-streaming phenomenon, which results from the fluid motion induced by high-intensity sound waves, can be used to remove these nonspecifically bound proteins to allow more accurate determinations and reuse of these devices. We present a computational and experimental study of the acoustic-streaming phenomenon induced by Surface acoustic waves.A coupled-field fluid-structure interaction (FSI) model of a Surface-acoustic-wave (SAW) device based on a micrometer-sized piezoelectric substrate (YZ-LiNbO3) in contact with a liquid loading was developed to study the Surface-acoustic-wave interaction with fluid loading. The fluid domain was modeled using the Navier-Stokes equation; the arbitrary Lagrangian-Eulerian approach was employed to handle the mesh distortions arising from the motion of the solid substrate. The fluid-solid coupling was established by maintaining stress and displacement continuity at the fluid-structure interface. A transient analysis was carried out by applying ... Source: www.foxnews.com --- 19 hours ago
Detroit Mayor Kwame Kilpatrick is now charged with exchanging romantic text messages with additional women in the scandal that has him fighting allegations that he lied under oath about an intimate relationship with his former chief of staff. ... Source: www.independent.co.uk --- 22 hours ago
Radek Stepanek of the Czech Republic was the only seeded player to fall on a rain-interrupted opening day of the Toronto Masters. ... Source: pubs.acs.org --- 21 hours ago
A. Giaquinto, Zhaoxia Liu, Andrew Bach, and Yuri Kazakevich Web Release Date: Wed, 23 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/ac800772s ...
Source: xlink.rsc.org --- 13 hours ago
A gold nanoparticle supported by triethylene glycol ligands has been demonstrated to act as a specific colorimetric sensor for aqueous mercury(ii) ion. In this process, ligand abstraction from the gold Surface by the mercury ion occurs prior to the color change. ... Source: www2.baldwincity.com --- 14 hours ago
Students, teachers and staff at Vinland Elementary School are about to get a 35-ton lesson in recycling. ... Source: artcompetitionslist.blogspot.com --- 12 hours ago
Announcing three new competitions, the results of which will be exhibited at the upcoming 15th semi-annual SDA Conference, "Off the Grid", which will take place in Kansas City, MO May 28th-31st, 2009. The competitions include: "Textile Fusion: An interactive Fashion Performance" at the Nelson-Atkins Art Museum, entry deadline Feb. 1, 2009; "Surface Matters" SDA members show at the Belger Art ... Source: www.theinsider.com --- 23 hours ago
According to Rush & Molloy of the NY Daily News , the police chief of Shreveport, La does not believe that actors Josh Brolin and Jeffrey Wright were treated unfairly during their recent arrest earlier this month, despite new details about an alleged cell-phone video that shows the two men being pepper-sprayed and one tasered. Someone who claims to have seen the camera phone video told Rush & Molloy "It shows Josh trying to calm down the cops (outside the Stray Cat bar). He's saying, "It's cool, man. Everything's good." The source went on to say that the footage also shows Brolin and Wright hugging -- that's when the police allegedly mace them. "Then they (police) tackle Wright and taser him. You also hear someone saying, 'What are you doing to that man? It's disgraceful." Shreveport police spokesman, Sgt . Kevin Goodwin told the NY Daily News , "We've heard about this video. We'd love to see it, if someone would like to send it to us." "The Insider's" call to the Shreveport was not immediately returned. [Read full story on The Insider] ... Source: www.fijitimes.com --- 22 hours ago
THE Kriz Signs Rewa soccer team management has alleged sabotage of the team's preparation by former officials and outsiders, as the side prepares for the Battle of the Giants. ... Source: foxsports.com.au --- 10 hours ago
THE downfall of Paul McNamee, one of Australia's most successful sporting administrators, as chief executive of Melbourne is a timely marker for a football code that wants to take over the world. ... Source: www.itnews.com.au --- 1 day ago
A set of tools for performing 'cold boot' data recoveries has been posted.. ... Source: www.canada.com --- 39 minutes ago
A former Saskatoon doctor, now charged with four counts of sexual assault, made a female patient undress and gave her a breast examination when she went to him seeking help for depression, one of the women alleged Wednesday. ... Source: www.lemarssentinel.com --- 15 hours ago
The northeast corner of the parking lot at the Plymouth County Courthouse is deteriorating and in need of repair. The Plymouth County Supervisors on Tuesday directed Tom Rohe, Plymouth County... ... Source: www.fwicki.com --- 18 hours ago
TEMPLE, Texas - (Business Wire) Wilsonart International executives reinforced the company ? s commitment to the Solid Surface market at the annual distributor meeting in Dallas, July 14. Bill DiGaetano, president of Wilsonart North America ... ... Source: www.xtremevbtalk.com --- 16 hours ago
Hello I am wondering how to read a single pixel from a Surface in DirectX 8. I already found out that I need to lock the Surface (which flags do I need?) and then maybe use DXCopyMemory, but I don't know how to do it and google is not quite helpful in this case. Has anyone ever done this... ... Find more results for Surface on RSSMicro.com |
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While Sony did not unveil any new hardware at the company's E3 press conference , new photos are beginning to show up around the Net that lead us to believe they're hard at work on an updated version of the PSP. Kotaku reports that forums members from PSPChina BBS have captured the rumored PSP-3000, identified by its PlayStation logo button that would replace the "home" button currently on the original and slim PSP models. The "new" PSP also features an onboard microphone located to the right of the volume controls. While these photos certainly look convincing, we're still going to have to label them as rumors for now. We'll update you if Sony ever confirms their validity. What would you want to see from the next PSP? Built-in flash memory? Larger battery life? Let us know in the comments section. More pictures of the rumored PSP-3000 after the jump. ... ...
Xingyi Deng, Albert Verdaguer, Tirma Herranz, Christoph Weis, Hendrik Bluhm, and Miquel Salmeron Web Release Date: Wed, 23 Jul 2008 00:00:00 EDT (Research Article) DOI: 10.1021/la8011052 ...
Paola Nativo, Ian A. Prior, and Mathias Brust Web Release Date: Tue, 22 Jul 2008 00:00:00 EDT (Articles) DOI: 10.1021/nn800330a ...
clipped by: Mohir clipper's remarks: "We will help with navigation, but also with astronauts' health as well," Li said. "We want them to avoid the stress of getting lost, or getting frustrated with the equipment. Lunar navigation isn't just a technology problem, it's also biomedical." The researchers have named the entire system the Lunar Astronaut Spatial Orientation and Information System (LASOIS). Clip Source: www.dailygalaxy.com our nearest neighbor in our small solar system, our moon, is totally devoid of any GPS system. So when NASA returns to the moon, hopefully by 2020, having some way to navigate from a to b – even if it isn’t to pay the bills – would be a big plus So the same Ohio State University researcher who is helping the Mars Rovers navigate across their tricky terrain, will now also be leading a campaign to help humans navigate across the Surface of the moon. This task is falling to Ron Li, the Lowber B. Strange Designated Professor of civil and environmental engineering and geodetic science, and he has a plan. Without the orbiting satellites to create an actual GPS system, Li will use a collection of lunar beacons, stereo cameras and orbital imaging sensors to create a GPS like mapping of the moon. NASA has awarded Li $1.2 million over the next three years to develop this system that will feel a lot like GPS, but work very differently. Tags: gps , moon ...