Pancreas

Source: au.rd.yahoo.com --- 25 days ago
BETHESDA, Maryland (Reuters) - Researchers working on an artificial Pancreas believe they are just a few years away from a nearly carefree way for people with diabetes to monitor blood and inject insulin as needed. ...

Source: www.reuters.com --- 25 days ago
BETHESDA, Maryland (Reuters) - Researchers working on an artificial Pancreas believe they are just a few years away from a nearly carefree way for people with diabetes to monitor blood and inject insulin as needed. ...

Source: timesofindia.indiatimes.com --- 25 days ago
Researchers working on an artificial Pancreas believe they are just a few years away from a nearly carefree way for people with diabetes to monitor blood and inject insulin as needed. ...

Source: www.ncbi.nlm.nih.gov --- 38 days ago
Related Articles Identification of phylogenetically conserved enhancer elements implicated in Pancreas development in the WISP1 and CTGF orthologs. Genomics. 2008 Jul 7; Authors: Kapasa M, Serafimidis I, Gavalas A, Kossida S WISP1 and CTGF are members of the CCN family of growth factors encoding extracellular matrix proteins participating in several developmental and tumorigenic processes. Both are induced by the WNT signaling pathway, and microarray data suggest that expression of WISP1 and CTGF is repressed by Neurogenin3 (Ngn3), a transcription factor directing specification of the endocrine Pancreas. Single-cell reverse transcription polymerase chain reaction analysis suggested that this was a cell autonomous effect. To identify possible common regulatory networks involved in WISP1 and CTGF gene expression, their genomic regions were searched for common transcription factor motifs using a combination of in silico approaches and documented knowledge concerning Pancreas development. This analysis revealed the presence of a conserved enhancer in both CTGF and WISP1 regulatory regions in 10 species covering a wide evolutionary distance. This enhancer contains binding sites for Ngn1/3 and transcription factors that are critically involved in Pancreas development. Furthermore, it contained binding sites for three additional transcription factor families, which may indicate novel players are involved in this process. PMID: 18616996 [PubM ...

Source: www.ncbi.nlm.nih.gov --- 34 days ago
Related Articles Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after Pancreas transplantation. Clin Immunol. 2008 Jul;128(1):23-30 Authors: Laughlin E, Burke G, Pugliese A, Falk B, Nepom G CD4+ T cells specific for the diabetes-associated autoantigen GAD65 were analyzed using peripheral blood samples after Pancreas transplantation in subjects with T1D with clinical evidence of recurrent autoimmune diabetes. MHC class II tetramers facilitated the identification and cloning of antigen-specific autoreactive cells, which were found at several time points over a multiyear span, in spite of chronic immunosuppression of the subjects. Comparisons of TCR clonotypes by cDNA sequencing revealed that identical T cells were present in the circulation, separated by long time intervals, consistent with a persistent memory response associated with recurrent autoimmunity. PMID: 18455963 [PubMed - indexed for MEDLINE] ...

Source: www.ncbi.nlm.nih.gov --- 31 days ago
Related Articles [Pancreaticoduodenectomy for cancer of the head of the Pancreas] J Chir (Paris). 2008 Jan-Feb;145(1):9-15 Authors: Huguier M, Barrier A, Gouillat C, Suc B, Jaeck D, Launois B Many modifications of the original technique have been proposed to try to improve the results of the pancreaticoduodenectomy described by Whipple. To evaluate these modifications, we have reviewed randomized controlled trials, meta-analyses, and well-conducted retrospective series. Neither total pancreatectomy nor extended lymph node dissections have shown an improve of survival in retrospective studies. Preoperative evidence of mesenteric or portal vein involvement does not contraindicate pancreatic resection and survival rates are similar to those of patients with no venous involvement. Prospective trials and one meta-analysis have shown neither advantage nor disadvantage of pylorus-preserving pancreaticoduodenectomy or of pancreatico-gastric anastomosis. Three trials and one meta-analysis of pancreatico-gastric anastomosis have failed to demonstrate a decrease in the risk of pancreatic fistula. Two trials suggest that the risk of fistula formation is decreased by implantation of the pancreatic remnant into the jejunum or by trans-jejunal stenting of the pancreatico-jejunal anastomosis with external drainage; but these findings are not supported by a third trial. The results of the antisecretory use of somatostatin are contradictory. Leak and f ...

Source: www.ncbi.nlm.nih.gov --- 15 days ago
Related Articles Pancreas transplantation inside emilia-romagna, Italy: referral pattern, demand forecasting, and organ availability. Transplant Proc. 2008 Jul-Aug;40(6):2027-8 Authors: Bonucchi D, Longhitano E, Gerunda G, Baldini A, Masetti M, Ravera F, De Amicis S, Albertazzi V, Mori G, Savazzi A, Albertazzi A In Italy, referral of diabetic patients for Pancreas transplantation (PT) is an unstructured process, resulting in a low rate of activity and late referrals, often when the patient has already undergone dialysis. In addition, the continuous improvement in Pancreas transplant alone, offering the opportunity to reduce cardiovascular risk due to proteinuria and reduced glomerular filtration rate (GFR), is rarely appreciated. We therefore analyzed (1) referral activity to PT during the time frame 2001-2005 in Emilia-Romagna, Italy (four million inhabitants), by collecting ICD 9 CM codes (55.69 + 52.80; 52.86 and 52.80 alone) by residence of the patient; (2) demand for PT among a sample population of 1670 diabetes patients, whose charts were reviewed for the type of diabetes and presence of overt diabetic nephropathy (DN: proteinuria > 300 mg/24 h and/or GFR < 60 mL/min); (3) potential Pancreas availability as the ratio between Pancreas and hearts utilized (UP/HR) in different areas of our country. As a results, (1) referral activity reached 8.4 PT per million people in 5 years in the whole region, ranging from 2.6 in the province w ...

Source: www.ncbi.nlm.nih.gov --- 16 days ago
Related Articles Progressive metaplastic and dysplastic changes in mouse Pancreas induced by cyclooxygenase-2 overexpression. Neoplasia. 2008 Aug;10(8):782-96 Authors: Colby JK, Klein RD, McArthur MJ, Conti CJ, Kiguchi K, Kawamoto T, Riggs PK, Pavone AI, Sawicki J, Fischer SM Cyclooxygenase-2 (COX-2) overexpression is an established factor linking chronic inflammation with metaplastic and neoplastic change in various tissues. We generated transgenic mice (BK5.COX-2) in which elevation of COX-2 and its effectors trigger a metaplasia-dysplasia sequence in exocrine Pancreas. Histologic evaluation revealed a chronic pancreatitis-like state characterized by acinar-to-ductal metaplasia and a well-vascularized fibroinflammatory stroma that develops by 3 months. By 6 to 8 months, strongly dysplastic features suggestive of pancreatic ductal adenocarcinoma emerge in the metaplastic ducts. Increased proliferation, cellular atypia, and loss of normal cell/tissue organization are typical features in transgenic pancreata. Alterations in biomarkers associated with human inflammatory and neoplastic pancreatic disease were detected using immunohistochemistry. The abnormal pancreatic phenotype can be completely prevented by maintaining mice on a diet containing celecoxib, a well-characterized COX-2 inhibitor. Despite the high degree of atypia, only limited evidence of invasion to adjacent tissues was observed, with no evidence of distant metastases. How ...

Source: www.ncbi.nlm.nih.gov --- 18 days ago
Transcription factors involved in Pancreas development are expressed in paediatric solid pseudopapillary tumours. Histopathology. 2008 Jul 29; Authors: Galmiche L, Sarnacki S, Verkarre V, Boizet B, Duvillie B, Fabre M, Jaubert F Aims: Solid pseudopapillary tumours (SPT) are rare pancreatic tumours, especially in children. The origin of this benign tumour remains unknown. Mutations of beta-catenin, a gene essential for pancreatic development, are constantly found, leading to delocalization of immunohistochemical signals from the cytoplasm to the nuclei of tumour cells. The aim was to report clinical and histological data of eight children with SPT and explore the immunohistochemical expression of pancreatic duodenal homeobox (PDX) 1 and Sox9, known to be crucial for pancreatic development and linked to the beta-catenin cascade. Methods and results: Eight children with features suggestive of SPT underwent surgical resection. Tumours displayed typical histological appearances. One was incompletely resected and recurred. Immunolabelling revealed nuclear location of beta-catenin in all cases and strong cytoplasmic but no nuclear expression of PDX1 or Sox9 in all but one case. Conclusions: The clinical behaviour of SPT in the paediatric population is similar to its adult counterpart. Complete surgical resection is essential. PDX1 and Sox9 proteins are exclusively expressed in the cytoplasmic compartment in SPT, suggesting overexpression of th ...

Source: www.ncbi.nlm.nih.gov --- 14 days ago
Related Articles Neonatal diabetes with end-stage nephropathy: Pancreas transplantation decision. Diabetes Care. 2008 Aug 4; Authors: Esmatjes E, Jimenez A, Diaz G, Mora M, Casamitjana R, Pérez de Nanclares G, Castaño L, José Ricart M Objective: We describe a patient with a suggestive story of neonatal diabetes (ND) who had been erroneously considered as having type 1 diabetes and was referred to our hospital for Pancreas and kidney transplantation because of end-stage renal disease. Methods: After a molecular genetic study, the diagnosis of ND, due to a mutation in exon 34 of the ABCC8 gene, was made and Pancreas transplantation was ill-advised. Results: Four months after kidney transplantation the patient was switched from insulin to glibenclamide confirming that Pancreas transplantation would not have been a good decision. Conclusions: This is the first description of a patient with ND who developed diabetic nephropathy which progressed to end-stage renal disease and illustrates that careful endocrinological evaluation, including molecular genetic studies if necessary, of candidates for Pancreas transplantation is mandatory before a decision to transplant is made. PMID: 18678608 [PubMed - as supplied by publisher] ...

Source: www.cbsnews.com --- 13 days ago
The experimental device delivers insulin without involving the patient. ...

Source: www.msnbc.com --- 23 days ago
Researchers working on an artificial Pancreas believe they are just a few years away from a nearly carefree way for people with diabetes to monitor blood and inject insulin as needed. ...

Source: www.technologyreview.com --- 13 days ago
A device that reads glucose levels and delivers insulin may be close at hand. ...

Source: calendar.ucsf.edu --- 16 days ago
"GLI Transcriptional Complexes: Key Effectors of Oncogenic Networks in Pancreatic Cancer," presented by Martin Fernandez-Zapico, MD, Schulze Center for Novel Therapeutics, Mayo Clinic College of Medicine. Lunch will be provided. See abstract. 2340 Sutter St., Lurie Seminar Rm. Contact: Victoria Karno, 885-3846. ...

Source: www.citynews.ca --- 19 days ago
The technology could exist to make the worst aspects of living with the disease disappear. ...

Source: vocuspr.vocus.com --- 25 days ago
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Source: www.eitb24.com --- 25 days ago
They believe they can link two current technologies, continuous glucose monitoring and insulin pumps, into a seamless package. This mechanical pancrease could reduce the need for fingersticks and injections of insulin. ...

Source: content.karger.com --- 15 days ago
Cell Physiol Biochem 2008;22:353-362 (DOI:10.1159/000149814) ...

Source: www.overthelimit.info --- 21 days ago
Bethesda, Maryland- Different groups of researchers all attacking the problem from different directions are in agreement; the advent of a artificial Pancreas like device is just around the corner. Using the idea of an insulin pump, and continuous glucose administration and monitoring experts in the metabolic and health fields feel that the seamless union of these [...] ...