Molecule

Source: articles.moneycentral.msn.com --- 6 days ago
Amgen (NASDAQ: AMGN) today announced that it has licensed a clinical stage Molecule for the treatment of chronic and neuropathic pain to Ortho-McNeil-Janssen Pharmaceuticals, Inc. (OMJPI), a Johnson ...

Source: au.rd.yahoo.com --- 15 days ago
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Source: www.ncbi.nlm.nih.gov --- 5 days ago
Related Articles A high-throughput screening method for small-Molecule pharmacologic chaperones of misfolded rhodopsin. Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3224-30 Authors: Noorwez SM, Ostrov DA, McDowell JH, Krebs MP, Kaushal S PURPOSE: Many mutations in rhodopsin, including P23H, result in misfolding and mislocalization of the protein. It has been demonstrated that pharmacologic chaperones are effective in assisting the proper folding and targeting of P23H opsin. This study was designed to investigate a high-throughput screening strategy for identification of pharmacologic chaperones by using a combination of in silico, cell-based, and in vitro METHODS: methods. A library of 24,000 drug-like small molecules was screened by in silico molecular docking with DOCK5.1. The top hits were assayed in an in vitro competition assay. The selected compound was then assayed for pharmacologic chaperoning activity in stable cell lines expressing wild-type and P23H opsin. RESULTS: Beta-ionone was easily identified by the high-throughput screen. It strongly inhibits rhodopsin formation and, when incubated in cells expressing P23H opsin, resulted in a 2.5-fold rescue of P23H opsin. The screen also identified compound NSC45012 [1-(3,5-dimethyl-1H-pyrazol-4-yl)ethanone], a weak inhibitor of opsin regeneration and resulted in a 40% rescue of the mutant opsin. The level of rescue correlated well with the extent of inhibition. CONCLUSIONS: A combinati ...

Source: www.moreover.com --- 22 hours ago
BioNanomatrix, Inc., a developer of breakthrough nanoscale whole genome imaging platforms for genetic diagnostics, personalized medicine and biomedical research, today announced receipt of a grant from the National Human Genome Research Institute of ...

Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles Regulation of G Protein-Coupled Receptor Activities by the Platelet-Endothelial Cell Adhesion Molecule, PECAM-1. Biochemistry. 2008 Aug 2; Authors: Yeh JC, Otte LA, Frangos JA It is becoming increasingly evident that the cell-cell junction is a major signaling center. Here we show that the Galphaq/11 subunit of heterotrimeric G proteins forms a complex with platelet-endothelial cell adhesion Molecule 1 (PECAM-1), a junctional protein that has been shown to be involved in mechanosignaling in endothelial cells. To understand the role of PECAM-1 in this complex, we determined the critical regions of PECAM-1 involved in this interaction. By expressing truncated forms of PECAM-1 in human embryonic kidney (HEK293) cells, we found that the cytoplasmic domain of PECAM-1 is not required for its association with Galphaq/11. Domain swapping of PECAM-1 with intracellular cell adhesion Molecule 1 (ICAM-1), a protein that does not form a complex with Galphaq/11, provides evidence that the extracellular domain of PECAM-1 is critical for this interaction. This result also suggests that PECAM-1 does not directly interact with Galphaq/11. Coexpression of bradykinin receptor B2 (BKRB2), a Galphaq/11-coupled receptor, with PECAM-1 enhances formation of the PECAM-1-Galphaq/11 complex, suggesting an interaction between PECAM-1 and BKRB2. Co-immunoprecipitation experiments indicate that these two molecules indeed form a complex when expresse ...

Source: www.ncbi.nlm.nih.gov --- 6 days ago
Related Articles Dynamics of an anti-VEGF DNA aptamer: a single-Molecule study. Biochem Biophys Res Commun. 2008 Aug 22;373(2):213-8 Authors: Nick Taylor J, Darugar Q, Kourentzi K, Willson RC, Landes CF Single-Molecule fluorescence resonance energy transfer (SMFRET) was used to study the interaction of a 25-nucleotide (nt) DNA aptamer with its binding target, vascular endothelial growth factor (VEGF). Conformational dynamics of the aptamer were studied in the absence of VEGF in order to characterize fluctuations in the unbound nucleic acid. SMFRET efficiency distributions showed that, while the aptamer favors a base-paired conformation, there are frequent conversions to higher energy conformations. Conversions to higher energy structures were also demonstrated to be dependent on the concentration of Mg2+-counterion by an overall broadening of the SMFRET efficiency distribution at lower Mg2+ concentration. Introduction of VEGF caused a distinct increase in the frequency of lower SMFRET efficiencies, indicating that favorable interaction of the DNA aptamer with its VEGF target directs aptamer structure towards a more open conformation. PMID: 18555799 [PubMed - indexed for MEDLINE] ...

Source: www.moreover.com --- 1 day ago
Researchers reported recently that they found a new Molecule, which kills kidney cancer cells. ...

Source: www.ncbi.nlm.nih.gov --- 4 days ago
Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor Molecule, in neointimal formation after vascular injury in mice. Circulation. 2008 Jun 17;117(24):3079-87 Authors: Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, Sagara J, Nakayama J, Taniguchi S, Ikeda U BACKGROUND: Inflammatory cytokines such as interleukin (IL)-1 beta and IL-18 play an important role in the development of atherosclerosis and restenosis. Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein that regulates caspase-1-dependent IL-1 beta and IL-18 generation; however, the role of ASC in vascular injury remains undefined. Here, we investigated the contribution of ASC to neointimal formation after vascular injury in ASC-deficient (ASC(-/-)) mice. METHODS AND RESULTS: Wire-mediated vascular injury was produced in the femoral artery of ASC(-/-) and wild-type mice. Immunohistochemical analysis revealed that ASC was markedly expressed at the site of vascular injury. Neointimal formation was significantly attenuated in ASC(-/-) mice after injury. IL-1 beta and IL-18 were expressed in the neointimal lesion in wild-type mice but showed decreased expression in the lesion of ASC(-/-) mice. To investigate the contribution of bone marrow-derived cells, we developed bone marrow-transplanted mice and found that neointimal formation was significantly decreased i ...

Source: sports.indiatimes.com --- 15 days ago
The world doping agency said that Riccardo Ricco tested positive at the Tour de France after a secret Molecule was planted in the blood booster EPO. ...

Source: blog.us.playstation.com --- 20 days ago
For those of you that have seen the PlayStation E3 press conference (and that can include all of you now), one of the highlights was something that’s typically the slowest part of these events - the business recap. Thanks to the folks at Media Molecule, a Celtics-clad Sackboy escorted SCEA CEO Jack Tretton through the [...] ...

Source: www.prnewswire.com --- 1 day ago
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Source: www.moreover.com --- 5 days ago
Therapeutics Daily Aug 2 2008 12:28AM GMT ...

Source: www.drugs.com --- 12 hours ago
IRVINE, Calif.--(BUSINESS WIRE)--Cortex Pharmaceuticals, Inc. (AMEX: COR - News) reported that top-line data from its first Phase IIa study in opiate-induced respiratory depression (RD) demonstrated that a single oral dose of 2100mg of AMPAKINE... ...

Source: www.moreover.com --- 1 day ago
SmartBrief Aug 6 2008 7:37AM GMT ...

Source: www.physicsforums.com --- 25 days ago
Can someone explain if my understanding is correct- that temperature of say a liquid is proportional to the speed of the molecules? My idea is if there was a way to sort different molecules by... ...