LINKAGE

Source: www.ncbi.nlm.nih.gov --- 4 days ago
Related Articles A multiple splitting approach to LINKAGE analysis in large pedigrees identifies a LINKAGE to asthma on chromosome 12. Genet Epidemiol. 2008 Oct 6; Authors: Bellenguez C, Ober C, Bourgain C Large genealogies are potentially very informative for LINKAGE analysis. However, the software available for exact non-parametric multipoint LINKAGE analysis is limited with respect to the complexity of the families it can handle. A solution is to split the large pedigrees into sub-families meeting complexity constraints. Different methods have been proposed to "best" split large genealogies. Here, we propose a new procedure in which LINKAGE is performed on several carefully chosen sub-pedigree sets from the genealogy instead of using just a single sub-pedigree set. Our multiple splitting procedure capitalizes on the sensitivity of LINKAGE results to family structure and has been designed to control computational feasibility and global type I error. We describe and apply this procedure to the extreme case of the highly complex Hutterite pedigree and use it to perform a genome-wide LINKAGE analysis on asthma. The detection of a genome-wide significant LINKAGE for asthma on chromosome 12q21 illustrates the potential of this multiple splitting approach. Genet. Epidemiol. 2008. (c) 2008 Wiley-Liss, Inc. PMID: 18839415 [PubMed - as supplied by publisher] ...

Source: coding.derkeiler.com --- 3 days ago
Summary: I am primarily a CoolGEN developer using COBOL mostly to write ... More by accident than design we tracked this down to an INITIALIZE ... calling program. ... When I step thru the subroutine, I find that Q has the value ... ...

Source: la.curbed.com --- 11 days ago
· Saga of one of the suspects in Malibu fire ; he knew, lied [KNBC] · Worldwide Fido awards will tape this Friday in Santa Monica [Yo Venice] · Latest photo, news on the Gold Line Construction from Metro [Bottleneck Blog] · More on that big Hilton/Waldorf Astoria fight underway in BH [LA Times] · Glendale's tough smoking ban : You even can't light up at Americana [GNP] · More on Related's purchase of that downtown senior center [Globe St] · Legality of that Silver Lake Boulevard billboard now being questioned [KNBC] ...

Source: curbed.com --- 5 days ago
· 7 firms, including Seaport guys, picked to develop East 125th Street [Crain's] · Amount of prime office space for rent jumped 43% last quarter [Bloomberg] · West Chelsea's new +Art can cater to buyers' sexual preferences [Vanishing NY] · Wanna throw a New Years' Eve party in Times Square ? Pony up $150k [Crain's] · Broker-blogger: 'people are not shy about making offers below asking ' [Comitini] · Will financial fallout slow Harlem's gentrification? [NYT] · Average sales price of one- to three-family Brooklyn homes is down [TRE] · Guggenheim to celebrate building restoration with free admission [NYology] · Victorian Flatbush rezoning gets it right, says blogger [Flatbush Gardener] ...

Source: www.schlockmercenary.com --- 11 days ago
Today’s score: Stamina Fail. Parenting Win. Husband Fail. Sandra told me WEEKS ago that her short called “Stories That Bind” was up at The Lorelei Signal, an online magazine. I was supposed to link you to it BEFORE it vanished into the archives. That happens on October 1st. See, honey? I didn’t wait too long! If you like [...] ...

Source: www.ultrashock.com --- 4 days ago
Hey! It's like this. My Flash has music and a preloader, but because of how the music is being exported to frame 1 in the LINKAGE property, so that... ...

Source: pop.wizbangblog.com --- 5 days ago
Jennifer Lopez says she would send her kids to Scientology school and suggest people not judge the religion without knowing about it. Oh ok JLo. Next you'll be telling... ...

Source: blogs.indiewire.com --- 8 days ago
I've been pretty busy this week, and I thought before I head into the weekend I'd link to a few pieces from the main indieWIRE site: Profile of "Rachel Getting Married" Writer Jenny Lumet NYFF Dispatch on "The Wrestler" and... ...

Source: pop.wizbangblog.com --- 11 days ago
Perhaps you've heard that TMZ is losing steam b/c readers feel the content isn't all that interesting? Last nights breaking news that 21 year old Jesse McCartneys neighbors called cops... ...

Source: www.thenetfool.com --- 18 hours ago
Jim’s posting on time this week?!? Impossible… YES! And it’s Sunday… …so here comes some LINK LOVE! It’s that time of the week again, and time to recap what has happened and what is to come. I had a busy week from the start, as a contest ended and a contest started. But not only that, the stock market (once again) crashed to smithereens in the face of the highest reading on the VIX (AKA, the “fear index”) in history. So people are scared now right? Well well well… looking like a mighty fine time to get some capitulation off our lows, at least temporarily. “What’s this… ...

Source: www.altraps.com --- 10 days ago
“Me, Chris Bosh and Jose (Calderon) sat down after the scrimmage (last week) and it was like, ‘Man, we have a real shot here,’ ” newcomer Jermaine O’Neal said. “We’ve got a real shot. “Obviously, we have the talent on paper and if we mentally believe that and bring that swagger every day, that we’re the [...] ...

Source: www.lowyinterpreter.org --- 13 hours ago
A China milestone : 8 October marked the day on which modern China had 'lived for more time under the reform and opening up era than under Mao’s era.' And just to drive home the point about Chinese modernisation, this week saw the launch of a new Chinese news magazine called Blog Weekly, which republishes blog posts in print form. The magazine offers payment for eyewitness blog accounts of major events. Canada is going to the polls, with the opposition Liberals proposing a pretty radical green tax agenda . It might be doomed , however. The US looks set to remove North Korea from its list of terrorist sponsors, a move that might keep nuclear negotiations alive. A map showing how many FTAs various countries have signed. Interesting to note that China and South East Asia are still pretty light on. (H/t Barnett ) ...