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Irritable Bowel Syndrome

 
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Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles Probiotic effects on intestinal fermentation patterns in patients with Irritable Bowel Syndrome. World J Gastroenterol. 2008 Aug 28;14(32):5020-4 Authors: Barrett JS, Canale KE, Gearry RB, Irving PM, Gibson PR AIM: To determine whether Lactobacillus casei strain Shirota (Yakult(R)) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in Irritable Bowel Syndrome (IBS). METHODS: 18 patients with IBS (Rome II criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult(R) daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of first rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no significant improvement in the symptom score with probiotic therapy, except for wind (P = 0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median final score 5.3 (IQR 3.9-5.9), 55% reduction; n = 6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult(R) is effective in altering fermenta ...
Source: www.ncbi.nlm.nih.gov --- 28 days ago
Related Articles Irritable Bowel Syndrome: an international study of symptoms in eight countries. Eur J Gastroenterol Hepatol. 2008 Jul;20(7):659-67 Authors: Gerson CD, Gerson MJ, Awad RA, Chowdhury A, Dancey C, Poitras P, Porcelli P, Sperber A, Wang WA OBJECTIVES: This report is a preliminary comparative study of Irritable Bowel Syndrome symptoms in eight countries, USA, Mexico, Canada, England, Italy, Israel, India, and China. We also assessed global symptom patterns and correlations and relationships to several psychosocial variables. METHODS: Two hundred and thirty-nine participants completed a Bowel symptom scale composed of four symptoms, abdominal pain or discomfort, bloating, diarrhea, and constipation as well as two psychosocial questionnaires, quality of relationship and attribution of symptoms to physical or emotional factors. RESULTS: Pain score in Italy, with the least urban population, was significantly higher than six of the seven other countries whereas it was lowest in India and England. Bloating was highest in Italy and constipation was highest in Mexico, both significantly higher than five other countries. Diarrhea was higher in China than five other countries. All significance values were P<0.05. Globally, diarrhea was less common than constipation, P<0.001 and bloating significantly correlated with constipation as well with pain, P<0.05. Composite analysis of psychosocial variables and symptoms indicated that famil ...
Source: www.moreover.com --- 14 days ago
Correspondence to:Dr M Pimentel, GI Motility Program, Cedars-Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA; pimentelm@cshs.org The first 150 words of the full text of this article appear below. ...
Source: www.ncbi.nlm.nih.gov --- 27 days ago
Related Articles Probiotics and Irritable Bowel Syndrome: Rationale and Clinical Evidence for Their Use. J Clin Gastroenterol. 2008 Aug 5; Authors: Barbara G, Stanghellini V, Cremon C, De Giorgio R, Gargano L, Cogliandro R, Pallotti F, Corinaldesi R Growing evidence suggests a potential role of intestinal microbiota in Irritable Bowel Syndrome (IBS) pathophysiology and symptom generation. Earlier studies based on classic microbiologic techniques hypothesized the presence of qualitative changes in intestinal microbiota in IBS patients. Recently, studies with molecular techniques have provided evidence of significant changes in microbial profiles in IBS and that the composition may be correlated with certain symptoms reported by patients. Although these studies are far from being exhaustive and conclusive they provide promising results that deserve further investigation. In addition, initial evidence indicated the presence of increased amounts of bacteria in the upper small intestine of IBS patients, a condition know as small intestinal bacterial overgrowth. However, the results of these studies have provided contradictory results suggesting that this area requires further work. These qualitative and quantitative changes in intestinal microbiota may induce different effects on the intestinal mucosa including mucosal barrier defects and immune activation which may contribute to symptom generation. Studies in IBS patients have attempted to ...
Source: www.ncbi.nlm.nih.gov --- 33 days ago
Related Articles Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrhea-predominant Irritable Bowel Syndrome. Aliment Pharmacol Ther. 2008 Jul 30; Authors: Zeng J, Li YQ, Zuo XL, Zhen YB, Yang J, Liu CH Background: The intestinal permeability is increased in patients with diarrhea-predominant Irritable Bowel Syndrome (D-IBS). Aim: To determine the possible efficacy of lactic acid bacteria on the increased intestinal permeability in D-IBS. Methods: Treatment was employed for 4 weeks in a randomized single blind placebo controlled study with 30 D-IBS patients. Patients were given either probiotic fermented milk (Streptococcus thermophilus, Lactobacillus bulgaricus, Lactobacillus acidophilus and Bifidobacterium Longum) or milk beverage containing no bacteria. The clinical symptoms were scored and intestinal permeability was measured by a triple sugar test before and after treatment. Results: Small Bowel permeability was measured as the ratio of lactulose and mannitol recovery and colonic permeability was measured as the total mass of sucralose excretion (mg). After probiotics treatment, small Bowel permeability decreased significantly from 0.038(0.024) at baseline to 0.023(0.020) (P=0.004), the proportion of patients with increased small Bowel permeability was lower than baseline (28.6% versus 64.3%, P=0.023). However, colonic permeability improved neither in the probiotics group nor in ...
Source: www.ncbi.nlm.nih.gov --- 11 days ago
Related Articles The prevalence of small intestinal bacterial overgrowth in Irritable Bowel Syndrome: IBS vs healthy controls (not historical definitions). Gut. 2008 Sep;57(9):1334-5 Authors: Pimentel M PMID: 18719147 [PubMed - in process] ...
Source: www.ncbi.nlm.nih.gov --- 5 days ago
Related Articles Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses. Biol Psychiatry. 2008 Aug 22; Authors: O'Mahony SM, Marchesi JR, Scully P, Codling C, Ceolho AM, Quigley EM, Cryan JF, Dinan TG BACKGROUND: Adverse early life events are associated with a maladaptive stress response system and might increase the vulnerability to disease in later life. Several disorders have been associated with early life stress, ranging from depression to Irritable Bowel Syndrome. This makes the identification of the neurobiological substrates that are affected by adverse experiences in early life invaluable. METHODS: The purpose of this study was to assess the effect of early life stress on the brain-gut axis. Male rat pups were stressed by separating them from their mothers for 3 hours daily between postnatal days 2-12. The control group was left undisturbed with their mothers. Behavior, immune response, stress sensitivity, visceral sensation, and fecal microbiota were analyzed. RESULTS: The early life stress increased the number of fecal boli in response to a novel stress. Plasma corticosterone was increased in the maternally separated animals. An increase in the systemic immune response was noted in the stressed animals after an in vitro lipopolysaccharide challenge. Increased visceral sensation was seen in the stressed group. There was an alteration of the fec ...
Source: www.ncbi.nlm.nih.gov --- 22 days ago
Related Articles Repeated electro-acupuncture attenuates chronic visceral hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat Irritable Bowel Syndrome model. Life Sci. 2008 Jul 22; Authors: Tian SL, Wang XY, Ding GH Acupuncture has been used in clinical trials for the treatment of abdominal pain in patients with Irritable Bowel Syndrome (IBS). However, scientific evidence is still lacking and the underlying mechanism remains largely unexplored. The aim of this study was to examine the effects of repeated administration of electro-acupuncture (EA) on chronic visceral hypersensitivity and on the phosphorylation of spinal cord N-methyl-d-aspartic acid (NMDA) receptors in a rat model of IBS. The results showed that repeated administration of EA at bilateral points of Zu-san-li (ST-36) and Shang-ju-xu (ST-37) significantly attenuated chronic visceral hypersensitivity induced in young adult rats by neonatal colon irritation. Such an effect was not seen in either of the two controls: sham-EA at ST-36 and ST-37 without electrical stimulation and EA at control points (BL-62 and tail). Furthermore, rats with chronic visceral hypersensitivity exhibited high-level expression of phosphorylated NMDA receptor subunit 1 (pNR1) in the spinal cord (L4-L5 segments), which was markedly attenuated by EA treatment. In addition, EA at ST-36 and ST-37 neither altered the pain threshold of normal rats nor affected the expression of pNR1 in ...
Source: www.medicalnewstoday.com --- 33 days ago
Two new review articles that cover therapeutic approaches to Irritable Bowel Syndrome (IBS) in the July issue of Nutrition in Clinical Practice, cite growing evidence that probiotics, and specifically Bifidobacterium infantis 35624 (Bifantis®), are effective in helping manage IBS. Both articles point to data that suggest Bifantis (available in the U.S. ...
Source: content.karger.com --- 33 days ago
Digestion 2008;77:225-235 (DOI:10.1159/000150632) ...
Source: www.immunesupport.com --- 29 days ago
Research shows serotonin (5HT) disturbances play a role in both types of IBS with diarrhea (abnormally high) and with constipation (abnormally low). Corrective drugs were effective in trials but withdrawn owing to rare serious complications. With new dr ...
Source: www.immunesupport.com --- 10 days ago
Tracking of more than 9,000 patients 1 year after diagnosis with IBS or GERD finds significantly increased risk of a subsequent diagnosis with the other condition. [Source: <I>Digestive Diseases and Sciences</I>, Aug 22, 2008] ...
Source: empowher.com --- 5 days ago
I have a friend who is 31 years old and has the worst Irritable Bowel Syndrome. She cannot go in a car longer than about 30 minutes without having to (well you know what). Does anyone have any suggestions on what she can do? I am not well versed in the subject. Thanks. ...
Source: www.natural-remedies-for-you.com --- 28 days ago
If you suffer from attacks of constipation, diarrhea, or both you are not alone. If these symptoms occur frequently around stressful situations, you probably have a condition named Irritable Bowel Syndrome or IBS. Irritable Bowel Syndrome is quite common almost 20% of people suffer from it at some point in their life. Women are affected more then men. ...
Source: www.fightingfatigue.org --- 34 days ago
Dr. Sugar Answers: IBS Treatment With No Health Insurance? I’m pretty positive I have Irritable Bowl Syndrome. Are there any things you can do to treat it without going to see a doctor? I don’t have insurance and would like to avoid a costly office visit. Any advice you could give would be helpful. Fitsugar Complementary and alternative [...] ...
Source: www.fwicki.com --- 1 day ago
Irritable Bowel Syndrome is something that no one really wants to talk about, but more people need to hear about, especially since so many people suffer from it, most of them without realizing it. This condition affects an average of 50 percent of ... ...
Source: www.fwicki.com --- 31 days ago
Two new review articles that cover therapeutic approaches to Irritable Bowel Syndrome (IBS) in the July issue of Nutrition in Clinical Practice, cite growing evidence that probiotics, and specifically Bifidobacterium infantis 35624 (Bifantis?), are ... ...
Source: www.fwicki.com --- 31 days ago
Lexicon Pharmaceuticals has successfully completed a Phase I multiple-dose escalation study in normal volunteers with LX1031, its oral drug candidate for Irritable Bowel Syndrome. The Phase I trial was a randomized, double-blind, ascending multiple ... ...
Source: www.topix.com --- 34 days ago
Two new review articles that cover therapeutic approaches to Irritable Bowel Syndrome in the July issue of Nutrition in Clinical Practice, cite growing evidence that probiotics, and specifically Bifidobacterium ... ...
Source: www.topix.com --- 29 days ago
If you suffer from allergy symptoms, you could be at risk for developing Irritable Bowel Syndrome. ...

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