Insulin Resistance

Source: lifestyle.in.msn.com --- 5 days ago
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Source: www.moreover.com --- 3 days ago
New research suggests that vitamin K supplementation may help to slow the progression of Insulin Resistance, a condition that significantly increases an individualâs risk of developing type 2 diabetes and heart disease. ...

Source: www.moreover.com --- 5 days ago
ScienceDaily (Nov. 26, 2008) ? Vitamin K slowed the development of Insulin Resistance in elderly men in a study of 355 non-diabetic men and women ages 60 to 80 who completed a three-year clinical trial at the Jean Mayer Human Nutrition Research ...

Source: www.moreover.com --- 4 days ago
Vitamin K supplementation can significantly reduce Insulin Resistance in elderly men, say researchers. A pre-cursor to diabetes, Insulin Resistance occurs when the body cannot use Insulin properly, causing glucose to build up in the blood. ...

Source: www.ncbi.nlm.nih.gov --- 9 days ago
13 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Insulin Resistance These PubMed results were generated on 2008/11/22 PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. ...

Source: www.ncbi.nlm.nih.gov --- 23 hours ago
Related Articles Psychological Insulin Resistance: patient beliefs and implications for diabetes management. Qual Life Res. 2008 Nov 28; Authors: Brod M, Kongsø JH, Lessard S, Christensen TL PURPOSE: To define and understand patient psychological Insulin Resistance (PIR) and its impact on diabetes management. METHODS: Systematic literature review of peer-refereed journals using the MEDLINE database, including all articles in English from 1985 to 2007. The population included patients with type 1 and type 2 diabetes, Insulin naïve, and those currently using Insulin. A total of 116 articles were reviewed. RESULTS: PIR is impacted by patients' beliefs and knowledge about diabetes and Insulin, negative self-perceptions and attitudinal barriers, the fear of side effects and complications from Insulin use, as well as lifestyle adaptations, restrictions required by Insulin use, and social stigma. These etiological influences, both independently and in combination, constitute a patient's PIR and may result in the reluctance of patients to both initiate and intensify treatment, leading to delayed treatment initiation and compromised glucose control. CONCLUSIONS: PIR is complex and multifaceted. It plays an important, although often ignored, role in diabetes management. Assisting health care professionals in better understanding PIR from the patient's perspective should result in improved treatment outcomes. By tailoring treatments to patients' ...

Source: www.ncbi.nlm.nih.gov --- 23 hours ago
Related Articles Islet adaptive changes to fructose-induced Insulin Resistance: {beta}-cell mass, glucokinase, glucose metabolism and Insulin secretion. J Endocrinol. 2008 Nov 27; Authors: Maiztegui B, Borelli M, Raschia M, Del Zotto H, Gagliardino J beta-cell mass, hexokinase/glucokinase (HK/GK) activity, glucose metabolism and Insulin secretion were studied in the islets of rats with fructose-induced Insulin Resistance (IR). Normal male Wistar rats were fed a standard commercial diet and water without (control, C) or with 10% fructose (FRD) for 3 weeks. Blood glucose (strips), triglyceride (commercial kit) and Insulin (radioimmunoassay) levels were measured at the time of sacrifice. Glucose-induced Insulin release, glucose metabolism (14CO2 and 3H2O production from D-[U-14C]- and D-[5-3H]-glucose) and HK/GK activity (G-6-P production), transcription (RT-PCR), protein expression (Western blot) and cellular compartmentalization were measured in isolated islets (collagenase digestion). FRD rats presented normoglycemia but impaired glucose tolerance, hypertriglyceridemia, hyperinsulinemia, and increased HOMA-IR index. In these rats, beta-cell mass decreased significantly by 33%, with a 44% increase in the percentage of apoptotic cells. Glucose-induced Insulin release and islet glucose metabolism were higher in FRD rats. While GK activity (total and cytosolic fraction) and protein expression were significantly higher in FRD islets, HK sho ...

Source: www.moreover.com --- 5 days ago
BOSTONVitamin K slowed the development of Insulin Resistance in elderly men in a study of 355 non-diabetic men and women ages 60 to 80 who completed a three-year clinical trial at the Jean Mayer Human Nutrition Research Center on Aging at Tufts ...

Source: www.ncbi.nlm.nih.gov --- 20 days ago
38 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Insulin Resistance These PubMed results were generated on 2008/11/11 PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. ...

Source: www.moreover.com --- 5 days ago
Men's Health News Vitamin K slowed the development of Insulin Resistance in elderly men in a study of 355 non-diabetic men and women ages 60 to 80 who completed a three-year clinical trial at the Jean Mayer Human Nutrition Research Center on Aging at ...

Source: www.ncbi.nlm.nih.gov --- 9 days ago
Related Articles Selective COX2 inhibition improves whole body and muscular Insulin Resistance in fructose-fed rats. Eur J Clin Invest. 2008 Nov;38(11):812-819 Authors: Hsieh PS, Tsai HC, Kuo CH, Chan JY, Shyu JF, Cheng WT, Liu TT Background The effects of cyclooxygenase-1 (COX1) and cyclooxygenase-2 (COX2) inhibition on Insulin Resistance in subjects with the metabolic syndrome remain elusive. Aims of this study were to examine the effects of COX1 and COX2 inhibitors on whole body and muscular Insulin Resistance in fructose-fed rats, an animal model of the metabolic syndrome. Materials and methods The rats on regular or 60% fructose-enriched diets for 6 weeks were further divided into rats combined with or without piroxicam (a selective COX1 inhibitor) or celecoxib (a selective COX2 inhibitor) treatment for an additional 2 weeks. Euglycaemic hyperinsulinaemic clamp (EHC) with a tracer dilution method was performed at the end of the study. Results The present result showed that fructose-induced increases in systolic blood pressure and fasting plasma Insulin levels were significantly suppressed in rats treated with celecoxib but not piroxicam. In the EHC period, celecoxib significantly reversed fructose-induced decreases in whole body glucose uptake, mainly by glucose storage. Hepatic glucose production and whole body glycolysis were not significantly changed among groups. Celecoxib but not piroxicam significantly reversed fructose-ind ...

Source: www.ncbi.nlm.nih.gov --- 13 days ago
27 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Insulin Resistance These PubMed results were generated on 2008/11/18 PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. ...

Source: www.ncbi.nlm.nih.gov --- 15 days ago
Related Articles Rimonabant ameliorates Insulin Resistance via both adiponectin-dependent and adiponectin-independent pathways. J Biol Chem. 2008 Nov 13; Authors: Watanabe T, Kubota N, Ohsugi M, Kubota T, Takamoto I, Iwabu M, Awazawa M, Katsuyama H, Hasegawa C, Tokuyama K, Moroi M, Sugi K, Yamauchi T, Noda T, Nagai R, Terauchi Y, Tobe K, Ueki K, Kadowaki T Rimonabant has been shown to not only decrease the food intake and body weight, but also to increase serum adiponectin levels. This increase of the serum adiponectin levels has been hypothesized to be related to the rimonabant-induced amelioration of Insulin Resistance linked to obesity, although experimental evidence to support this hypothesis is lacking. To test this hypothesis experimentally, we generated adiponectin-knockout (adipo(-/-))ob/ob mice. After 21 days of treatment with rimonabant at 30mg/kgBW, the body weight and food intake decreased to similar degrees in the ob/ob and adipo(-/-)ob/ob mice. Significant improvement of Insulin Resistance was observed in the ob/ob mice following rimonabant treatment, associated with significant up-regulation of the plasma adiponectin levels, in particular, of high- molecular-weight adiponectin. Amelioration of Insulin Resistance in the ob/ob mice was attributed to the decrease of glucose production and activation of AMP-activated protein kinase (AMPK) in the liver induced by rimonabant, but not to increased glucose uptake by the skeleta ...

Source: www.ncbi.nlm.nih.gov --- 3 days ago
Related Articles Visceral Fat and Adiponectin: Associations with Insulin Resistance Are Tissue-Specific in Women. Metab Syndr Relat Disord. 2008 Nov 25; Authors: Coker RH, Williams RH, Yeo SE, Kortebein PM, Bodenner DL, Kern PA, Evans WJ Abstract Body fatness and its distribution are strongly and independently associated with peripheral Insulin action. However, these associations are limited in their ability to predict the independent nature of hepatic and peripheral Insulin Resistance, especially in obese women. To define the relationships more precisely between regional fat distribution and adiponectin, and hepatic and peripheral Insulin Resistance, we studied 22 obese (43 +/- 0.1%) women who underwent a dual-energy X-ray absorptiometry scan and a computed tomography scan at the L4-L5 level. An octreotide (60 ng . kg(-1) . min(-1)), glucagon (0.65 ng . kg(-1) . min(-1)), and two-step Insulin (0.25 mU . kg(-1) . min(-1) and 1.0 mU . kg(-1) . min(-1)) infusion was performed to quantify Insulin-mediated suppression of hepatic glucose production (SGP) and Insulin-stimulated glucose disposal (ISGD) in a simultaneous fashion. Hepatic glucose production (HGP) was measured using a primed, constant infusion of [6,6(2)H(2)] glucose. Mean plasma Insulin increased from 5.6 +/- 0.1 muU/mL at baseline to 15.1 +/- 1.5 muU/mL in the first stage, and to 80.7 +/- 0.5 muU/mL in the second stage. Although there was no significant relationship between v ...

Source: www.ncbi.nlm.nih.gov --- 23 days ago
Obstructive Sleep Apnea, Insulin Resistance and Steatohepatitis in Severe Obesity. Am J Respir Crit Care Med. 2008 Oct 31; Authors: Polotsky VY, Patil SP, Savransky V, Laffan A, Fonti S, Frame LA, Steele KE, Schweizer MA, Clark JM, Torbenson MS, Schwartz AR RATIONALE: Obstructive sleep apnea is associated with Insulin Resistance and liver injury. It is unknown whether apnea contributes to Insulin Resistance and steatohepatitis in severe obesity. OBJECTIVES: To examine whether sleep apnea and nocturnal hypoxemia predict the severity of Insulin Resistance, systemic inflammation, and steatohepatitis in severely obese individuals presenting for bariatric surgery. METHODS: We performed sleep studies, measured fasting blood glucose, serum Insulin, C-reactive protein, and liver enzymes in 90 consecutive severely obese individuals, 75 women and 15 men, without concomitant diabetes mellitus or preexistent diagnosis of sleep apnea or liver disease. Liver biopsies (n=20) were obtained during bariatric surgery. MEASUREMENTS AND MAIN RESULTS: Obstructive sleep apnea with the respiratory disturbance index of > 5 events/hr was diagnosed in 81.1% patients. The median respiratory disturbance index was 15+/- 29 events/hr and the median oxygen desaturation during apneic events was 4.6 +/- 1.8%. All patients exhibited high serum levels of C-reactive protein, regardless of the severity of apnea, whereas liver enzymes were normal. Oxygen desaturation great ...

Source: www.ncbi.nlm.nih.gov --- 16 days ago
22 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Insulin Resistance These PubMed results were generated on 2008/11/15 PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. ...

Source: www.ncbi.nlm.nih.gov --- 15 days ago
Related Articles Adipokines and Insulin Resistance. Mol Med. 2008 Nov-Dec;14(11-12):741-51 Authors: Rabe K, Lehrke M, Parhofer KG, Broedl UC Obesity is associated with an array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae has advanced rapidly over the past decades. Adipose tissue represents an active endocrine organ that, in addition to regulating fat mass and nutrient homeostasis, releases a large number of bioactive mediators (adipokines) that signal to organs of metabolic importance including brain, liver, skeletal muscle, and the immune system-thereby modulating hemostasis, blood pressure, lipid and glucose metabolism, inflammation, and atherosclerosis. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones adiponectin, chemerin, leptin, omentin, resistin, retinol binding protein 4, tumor necrosis factor-alpha and interleukin-6, vaspin, and visfatin on Insulin Resistance. PMID: 19009016 [PubMed - in process] ...

Source: www.ncbi.nlm.nih.gov --- 25 days ago
16 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Insulin Resistance These PubMed results were generated on 2008/11/06 PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. ...

Source: www.moreover.com --- 4 days ago
Results of a study published in the November issue of Diabetes Care showed that vitamin K supplementation slowed the progression of Insulin Resistance in men ages 60 to 80. ...

Source: www.moreover.com --- 26 days ago
Vitamin K supplementation for 36 months at doses attainable in the diet may reduce progression of Insulin Resistance in older men, according to the results of a randomized controlled trial. ...