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Source: www.ncbi.nlm.nih.gov --- 15 days ago
Dissecting colony development of Neurospora crassa using mRNA profiling and comparative Genomics approaches. Eukaryot Cell. 2008 Aug 1; Authors: Kasuga T, Glass NL Colony development, which includes hyphal extension, branching, anastomosis and asexual sporulation are fundamental aspects of the lifecycle of filamentous fungi; genetic mechanisms underlying these phenomena are poorly understood. We conducted transcriptional profiling during colony development of the model filamentous fungus, Neurospora crassa, using 70-mer oligonucleotide microarrays. Relative mRNA expression levels were determined for six sections of defined age excised from a 27 hr old N. crassa colony. Functional category analysis showed that the expression of genes involved in cell membrane biosynthesis, polar growth and cellular signaling were enriched at the periphery of the colony. The relative expression level of genes involved in protein synthesis and energy production were enriched in the middle section of the colony, while sections of the colony undergoing asexual development (conidiogenesis) were enriched in expression level for genes involved in protein/peptide degradation and unclassified proteins. A cross-examination of the N. crassa dataset with a published dataset of Aspergillus niger revealed shared patterns in the spatiotemporal regulation of gene orthologs during colony development. At present less than 50% of genes in N. crassa have functional annotati ... Source: www.ncbi.nlm.nih.gov --- 16 days ago
Related Articles Genomics of aortic valve disease. J Am Coll Cardiol. 2008 Aug 5;52(6):498; 498-9 Authors: Bella JN PMID: 18672174 [PubMed - in process] ... Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles Ultraconserved elements: Genomics, function and disease. RNA Biol. 2008 Jul 25;5(3) Authors: Baira E, Greshock J, Coukos G, Zhang L Evolutionary conservation has become a powerful tool to identify functionally important genomic sequences/elements in the human genome. There are 481 genomic segments longer than 200 base pairs (bp) that are absolutely conserved (100% identity with no insertions or deletions) between human, mouse and rat genomes. Such segments are known as ultraconserved elements (UCEs). Although our knowledge of UCEs is limited, most recent studies suggest that UCEs play a functional role in vertebrate genomes, such as serving as long-range enhancers of flanking genes, regulating splicing and epigenetic modifications, and functioning as transcriptional coactivator. Most recent studies show that expression of UCEs is consistently altered in tumors, strongly suggesting these elements may also be involved in human disease such as cancer development. PMID: 18708752 [PubMed - as supplied by publisher] ... Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles Translational Genomics: seeking a shared vision of benefit. Am J Bioeth. 2008 Mar;8(3):54-6; discussion W1-3 Authors: Burke W, Kuszler P, Starks H, Holland S, Press N PMID: 18570105 [PubMed - indexed for MEDLINE] ...
Source: repository.upenn.edu --- 6 days ago
The completion of the Human Genome Project and ongoing sequencing of mouse, rat and other genomes has led to an explosion of genetics-related technologies that are finding their way into all areas of biological research; the field of biorheology is no exception. Here we outline how two disparate modern molecular techniques, microarray analyses of gene expression and real-time spatial imaging of living cell structures, are being utilized in studies of endothelial mechanotransduction associated with controlled shear stress in vitro and haemodynamics in vivo. We emphasize the value of such techniques as components of an integrated understanding of vascular rheology. In mechanotransduction, a systems approach is recommended that encompasses fluid dynamics, cell biomechanics, live cell imaging, and the biochemical, cell biology and molecular biology methods that now encompass Genomics. Microarrays are a useful and powerful tool for such integration by identifying simultaneous changes in the expression of many genes associated with interconnecting mechanoresponsive cellular pathways. ... Source: cordis.europa.eu --- 12 days ago
The third European Science Foundation (ESF) conference on functional Genomics and disease is scheduled for 1 to 4 October in Innsbruck, Austria. Developments in functional Genomics technologies together with the expanding concept of systems … ... Source: radar.oreilly.com --- 15 days ago
[This is part of a series of posts that briefly describe the trends were currently tracking here at O'Reilly: 1 , 2 ] Genetic analysis software and hardware used to be very expensive, only for professionals—now it's trickling down to ProAms, and soon (under 5 years) will be widespread for consumer applications. This changes how drugs are developed and applied (don't test against 500 people and say whether it "works", figure out which genetic markers indicate the people it works for and sell to those), how diseases/conditions are diagnosed and treated, and our sense of self. Expect "interesting" (in the Chinese curse sense) interactions with privacy, workplace relations, and even parenthood. Watchlist: 23andme , Hugh Reinhoff's " My Daughter's DNA ". ... Source: www.cdc.gov --- 11 days ago
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Colleen McBride and colleagues argue that progress on a multifaceted research agenda is necessary to reap the full benefits and avoid the potential pitfalls of the emerging area of personalized Genomics. They also outline one element of this agenda, the Multiplex Initiative, which has been underway since 2006. ... Source: planet.nature.com --- 50 days ago
The availability of whole-genome association studies has redefined the genetic architecture of genetically complex disorders, and genotyping and resequencing will reveal new susceptibility genes for a wide range of common human diseases. The emphasis of the field is thus changing from focusing on the identification of susceptibility genes towards an understanding of mechanisms and potential applications. Following the successful inaugural conference in Hinxton, Cambridge, UK in July 2007, this second meeting, organised by Nature Genetics and the Wellcome Trust, will take place from 6 to 9 September 2008, at The Broad Institute of MIT and Harvard, Cambridge, MA, USA aims to address the following topics, across a range of common diseases: --The state of the art in gene-identification strategies --The transition from knowledge of susceptibility genes to understanding of mechanisms --Population genetics and genome evolution in common-disease genetics --The utility of risk prediction based on genetic and other available tests --Ethical, legal and social implications of personal genetic information. Please see the conference website for further details of the organizers, speakers, abstract submission, accommodation and more. ... Source: www.moreover.com --- 18 days ago
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Street Insider Aug 11 2008 1:38PM GMT ... Source: www.moreover.com --- 7 days ago
AGOWA Genomics, part of the international science-based company LGC, has added a Genome Sequencer FLX System from Roche to its technology portfolio. ... Source: www.sciencedaily.com --- 6 days ago
Genomics is accelerating improvements for converting plant biomass into biofuel -- as an alternative to fossil fuel for the nation's transportation needs. Now researchers lay out a path forward for how emerging genomic technologies will contribute to a substantially different biofuels future as compared to the present corn-based ethanol industry -- and in part mitigate the food-versus-fuel debate. ... Find more results for Genomics on RSSMicro.com |
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A team led by J. Craig Venter from the J. Craig Venter Institute has just published another paper on J. Craig Venter's favourite topic: J. Craig Venter. This study follows up on last year's publication of the complete sequence of Venter's genome , this time reporting a detailed analysis of a small but quite informative fraction of the genome: the exome , which consists of all of the pieces of DNA (called exons) that directly code for protein molecules. The exome is a favoured target of geneticists. There are two major reasons for this: firstly, the exome is enriched for functional sequence , whereas non-coding DNA has a much higher fraction of non-functional junk; and secondly, we understand protein-coding DNA much better than we do non-coding DNA . If a novel mutation alters a protein sequence, we have algorithms that can predict (with moderate accuracy) how likely it is to alter the function of the cell. In contrast, for most mutations in non-coding DNA we have almost no way to predict whether they are functional or not. So, like the drunkard looking for his keys under the lamp-post because the light is better there, geneticists are inclined to look hardest at the regions where they actually have some chance of finding something they can understand. Venter's mutations The article (which is open access, so you can read it yourself ) has a number of interesting factoids about Venter's protein-coding genome that are highly relevant to ...