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Source: www.nytimes.com --- 40 days ago
There seems to be a geographical pattern to European genetics. By analyzing people’s Genomes, geneticists can tell roughly where in Europe they come from. ... Source: www.ncbi.nlm.nih.gov --- 3 hours ago
Chimeric GB virus B Genomes containing hepatitis C virus p7 are infectious in vivo. J Hepatol. 2008 Sep 15; Authors: Griffin S, Trowbridge R, Thommes P, Parry N, Rowlands D, Harris M, Bright H BACKGROUND/AIMS: The development of new therapies for hepatitis C virus (HCV) infection has been hampered by the lack of a small animal model. GB virus B (GBV-B), which infects new world monkeys, has been proposed as a surrogate system for HCV replication. Despite their short genetic distance, however, difficulties exist when extrapolating results from GBV-B to the HCV system. One way of addressing this is the creation of chimeric GBV-B containing HCV elements. METHODS: Construction and analysis of GBV-B chimeras in which the p13 ion channel was replaced by its HCV counterpart, p7. RESULTS: Replacing all, or part of, the GBV-B p13 protein with HCV p7 resulted in viable chimeras which replicated at wild-type levels in marmosets following intra-hepatic RNA injection. Serum from one animal injected with chimeric RNA was infectious in three naïve recipients, indicating that chimeras formed fully infectious virions. Amantadine, which blocks the ion channel activity of both HCV and GBV-B proteins in vitro, also inhibited GBV-B replication in primary hepatocytes. CONCLUSIONS: These viruses highlight the potential for chimeric GBV-B in the development of HCV-specific therapies and will provide a means of developing HCV p7 as a therapeutic target. PMID: ... Source: www.reuters.com --- 3 days ago
WASHINGTON (Reuters) - Scientists have mapped the Genomes of the parasite that causes most cases of malaria outside Africa and a monkey parasite that is emerging as an important cause of malaria in people in Southeast Asia. ... Source: www.ncbi.nlm.nih.gov --- 23 days ago
Related Articles Comparative proteogenomics: combining mass spectrometry and comparative genomics to analyze multiple Genomes. Genome Res. 2008 Jul;18(7):1133-42 Authors: Gupta N, Benhamida J, Bhargava V, Goodman D, Kain E, Kerman I, Nguyen N, Ollikainen N, Rodriguez J, Wang J, Lipton MS, Romine M, Bafna V, Smith RD, Pevzner PA Recent proliferation of low-cost DNA sequencing techniques will soon lead to an explosive growth in the number of sequenced Genomes and will turn manual annotations into a luxury. Mass spectrometry recently emerged as a valuable technique for proteogenomic annotations that improves on the state-of-the-art in predicting genes and other features. However, previous proteogenomic approaches were limited to a single genome and did not take advantage of analyzing mass spectrometry data from multiple Genomes at once. We show that such a comparative proteogenomics approach (like comparative genomics) allows one to address the problems that remained beyond the reach of the traditional "single proteome" approach in mass spectrometry. In particular, we show how comparative proteogenomics addresses the notoriously difficult problem of "one-hit-wonders" in proteomics, improves on the existing gene prediction tools in genomics, and allows identification of rare post-translational modifications. We therefore argue that complementing DNA sequencing projects by comparative proteogenomics projects can be a viable approach to imp ... Source: www.moreover.com --- 12 days ago
ScienceDaily (Sep. 26, 2008) ? Researchers report the simultaneous completion of the first Genomes of wild Arabidopsis thaliana strains as part of the 1001 Genomes Project. ... Source: www.ncbi.nlm.nih.gov --- 38 days ago
Related Articles Individual Genomes instead of race for personalized medicine. Clin Pharmacol Ther. 2008 Sep;84(3):306-9 Authors: Ng PC, Zhao Q, Levy S, Strausberg RL, Venter JC The cost of sequencing and genotyping is aggressively decreasing, enabling pervasive personalized genomic screening for drug reactions. Drug-metabolizing genes have been characterized sufficiently to enable practitioners to go beyond simplistic ethnic characterization and into the precisely targeted world of personal genomics. We examine six drug-metabolizing genes in J. Craig Venter and James Watson, two Caucasian men whose Genomes were recently sequenced. Their genetic differences underscore the importance of personalized genomics over a race-based approach to medicine. To attain truly personalized medicine, the scientific community must aim to elucidate the genetic and environmental factors that contribute to drug reactions and not be satisfied with a simple race-based approach. PMID: 18714319 [PubMed - indexed for MEDLINE] ... Source: www.moreover.com --- 31 days ago
His Royal Highness Prince Ahmad bin Sultan bin Abdulaziz, Head of the Board of Directors at Saudi Biosciences, said 'This marks the first milestone in our goal to pioneer the personalized medicine era in the Arab world, and the next step is to lead a ... Source: networks.feedburner.com --- 27 days ago
Welcome to the September 14, 2008 edition of Gene Genie! Bloggers have begun to pick up posting with the end of summer, and it seems like everyday there’s a bunch of new interesting posts about the human genome. 96well at Reportergene presents “Trends in development of reporter genes.” Reportergene is also looking for bloggers/reporters [...] ... Source: www.iht.com --- 39 days ago
There seems to be a geographical pattern to European genetics. By analyzing people's Genomes, geneticists can tell roughly where in Europe they come from. ... Source: www.iht.com --- 39 days ago
There seems to be a geographical pattern to European genetics. By analyzing people's Genomes, geneticists can tell roughly where in Europe they come from. ...
Source: www.moreover.com --- 5 days ago
Xconomy Oct 6 2008 6:32PM GMT ... Source: www.technologyreview.com --- 23 days ago
Scanning DNA for structural changes brings new insight into disease. ... Source: www.moreover.com --- 23 days ago
Agriculture Under Secretary Gale Buchanan announced more than $9.4 million for research, education and extension in the genomics of sunflower, black cherry, peach, strawberry, apple, lettuce, potato and tomato to researchers and educators at eight ... Source: library.ua.edu --- 31 days ago
Genomes, browsers, and databases : data-mining tools for integrated genomic databases / Peter Schattner. Cambridge [UK] ; New York : Cambridge University Press, 2008. ... Source: discovermagazine.com --- 2 days ago
Researchers have decoded the Genomes of two different malaria parasites ... ... Source: www.msnbc.msn.com --- 3 days ago
Scientists have mapped the Genomes of the parasite that causes most cases of malaria outside Africa and a monkey parasite that causes malaria in people in Southeast Asia. ... Source: media.cleantech.com --- 3 days ago
Experts say more investment in plant science research, such as the wheat breakthrough, is crucial to future crop productivity. ... Source: www.medicalnewstoday.com --- 4 days ago
Complete Genomics Inc., a third-generation human genome sequencing company, has announced its formal launch as the world's first provider of large-scale human genome sequencing services. The company, which was established in March 2006, has been operating in "stealth mode" from a 32,000-square-foot facility near San Francisco. ... Source: www.cybermacro.com --- 34 days ago
Remember when scientists mapped the genome (genetic material) for SARS some years back? It filled 18 pages with little letters, a genetic code. It really did not stop SARS but it was interesting. I papered my wall with some of the print-out. Now a new study has begun to map the Genomes of rare,... ... Find more results for Genomes on RSSMicro.com |
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The Genomes of two malaria parasites are published today, in what malariologists say is a great step forward for their research. Plasmodium vivax is not the nastiest type of malaria. That’s Plasmodium falciparum , which had its genome published in 2002. But while it might not get as much attention as its more deadly cousin, malaria parasite Plasmodium vivax is an increasing problem, say the researchers who have just published its genome in Nature . Depending on which press release you read P. vivax is responsible for 125 million , 206 million , or 300 million cases of malaria world wide. The Nature paper that details the genome puts it at between 25% and 40% of the roughly 515 million annual cases. “Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared,” write the authors. “Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates.” ...