Estrogen

Source: www.ncbi.nlm.nih.gov --- 1 day ago
Estrogen therapy influence on periurethral vessels in postmenopausal incontinent women using Dopplervelocimetry analysis. Maturitas. 2008 Oct 7; Authors: Kobata SA, Girão MJ, Baracat EC, Kajikawa M, Di Bella V, Sartori MG, Jármy-Di Bella ZI Lack of Estrogen affects the urinary tract mainly by diminishing vascular, muscular and epithelial trophism, resulting in negative effects on continence in postmenopausal women. Therefore, the use of estrogens in these patients may revert these alterations and lead to an expressive improvement of the urinary symptoms. OBJECTIVE: Study the effect of topical Estrogen therapy (conjugated equine estrogens, estriol or promestriene) in periurethral vessels detected by Dopplervelocimetric analysis using, as parameters: the number of vessels, resistance and pulsatility indexes, as well as the minimum diastolic value. METHODS: Forty-one postmenopausal women with stress urinary incontinence were randomized into three groups according to different types of topical Estrogen received during 3 months. Group 1 received conjugated equine estrogens, group 2 received estriol and group 3 received promestriene. Periurethral Dopplervelocimetry analysis was done before Estrogen administration and during treatment in all groups. RESULTS: We observed an increase in the number of the periurethral vessels in group 1 and group 2, being higher in group 1 than in group 2. The pulsatility index remained unchanged in all three ...

Source: www.ncbi.nlm.nih.gov --- 7 days ago
Related Articles Estrogen Receptor {alpha} mediates the Epidermal Growth Factor -stimulated prolactin expression and release in lactotrophs. Endocrinology. 2008 Oct 1; Authors: Ben-Jonathan N, Chen S, Dunckley JA, Lapensee C, Kansra S Epidermal growth factor (EGF) is a potent regulator of cell function in many cell types. EGF-receptor (EGFR/ErbB1) activated Erk1/2 has been reported to activate Estrogen receptor (ER) in an Estrogen (E2)-independent manner. In the pituitary lactotrophs, both EGF and E2 stimulate PRL release but the nature of interactions between ErbB and ERalpha signaling is unknown. Our objectives were to: a) characterize EGF-induced PRL release, b) determine whether this effect requires ERalpha, and c) determine the molecular basis for cross talk between ErbB and ERalpha signaling pathways. Using GH3 cells, a rat lactotroph cell line, we report that EGF stimulates PRL gene expression and release in a dose- and time-dependent manner. EGF caused a rapid and robust activation of Erk1/2 via ErbB1 and induced phosphorylation of S118 on ERalpha in an Erk1/2-dependent manner. The global anti-Estrogen ICI 182780 and the ERalpha specific antagonist MPP, but not the ERbeta specific antagonist PHTPP, blocked the EGF-induced PRL release, indicating an ERalpha requirement. This was further supported by utilizing ERalpha knockdown by siRNA. Since the anti-estrogens did not block EGF-induced Mek-1 or Erk1/2 phosphorylation, ERalpha i ...

Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles Treatment of hypersexual behavior with oral Estrogen in an autistic male. South Med J. 2008 Sep;101(9):959-60 Authors: Jones MC, Okere K Hypersexual behavior can be exhibited by patients with autism. Several medications have been used in hypersexual paraphiliac male and elderly patient populations, including antiandrogens, Estrogen, gonadotropin-releasing hormone analogues, and selective serotonin reuptake inhibitors. Due to limited research in autistic patients exhibiting hypersexuality, physicians must base their medication selection on outcomes seen in patients with other conditions. PMID: 18708975 [PubMed - indexed for MEDLINE] ...

Source: www.ncbi.nlm.nih.gov --- 9 days ago
17 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Estrogen These PubMed results were generated on 2008/10/04 PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. ...

Source: www.ncbi.nlm.nih.gov --- 2 days ago
23 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Estrogen These PubMed results were generated on 2008/10/11 PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. ...

Source: www.ncbi.nlm.nih.gov --- 9 days ago
Related Articles Pregnancy weight gain is not associated with maternal or mixed umbilical cord Estrogen and androgen concentrations. Cancer Causes Control. 2008 Oct 1; Authors: Faupel-Badger JM, Hoover RN, Potischman N, Roberts JM, Troisi R The association of maternal weight gain with serum hormone concentrations was explored in 75 women who had healthy, singleton pregnancies. Estradiol, estriol, estrone, androstenedione, testosterone, dehydroepiandrosterone (DHEA), and DHEA sulfate concentrations were measured both in maternal and mixed umbilical cord serum to assess hormone levels in both the maternal and fetal circulation at delivery. Our data show no association of maternal or cord steroid hormone concentrations with pregnancy weight gain. Increased exposure to steroid hormones, especially estrogens, during pregnancy has been hypothesized to play a role in subsequent breast cancer risk for both mother and female offspring. Our results are not consistent with an effect of pregnancy weight gain being mediated by this pathway as reflected by hormone concentrations at the end of pregnancy. PMID: 18830676 [PubMed - as supplied by publisher] ...

Source: www.ncbi.nlm.nih.gov --- 12 days ago
45 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Estrogen These PubMed results were generated on 2008/10/01 PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. ...

Source: www.ncbi.nlm.nih.gov --- 10 days ago
Related Articles (Xeno)Estrogen regulation of food allergy. J Immunotoxicol. 2008 Jul;5(3):259-70 Authors: Guo TL Food allergy and other types of allergies are becoming epidemic in both the developed and developing countries. A large amount of information is available in literature that (xeno)estrogens can regulate the immune response in general, and the development of allergy in particular; however, the effect of (xeno)estrogens on food allergy is basically unknown. With increasing use of xenobiotics worldwide, chemicals with estrogenic activity have been accumulating in our environment. This review has summarized the current literature relating to the topic (xeno)Estrogen regulation of food allergy. The effect of (xeno)estrogens on enterocytes, proteases for protein hydrolysis, dendritic cells and T-regulatory cells in the gastrointestinal tract has been discussed. Finally, considering the current confusion in literature regarding the effect of phytoestrogen genistein on the immune system, a brief discussion has been included for its effect on T(H)1-T(H)2 polarization, and possibly food allergy in its relation to windows of exposure. Sufficient evidences exist to support the notion that (xeno)estrogens can regulate food allergy, with the developmental periods more sensitive. Further clinical and animal studies are needed to determine the causal relationship between the exposure of (xeno)estrogens and incidence of food allergy, and t ...

Source: www.ncbi.nlm.nih.gov --- 10 days ago
Related Articles Crucial role of Estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells. Endocrinology. 2008 Sep;149(9):4658-68 Authors: Chen YJ, Lee MT, Yao HC, Hsiao PW, Ke FC, Hwang JJ This study was to explore Estrogen receptor (ER) involvement in FSH and TGFbeta1-stimulated steroidogenesis in rat ovarian granulosa cells. We first determined the specific involvement of ERalpha and ERbeta in the process, and then investigated the molecular interaction of ERalpha and transcription coregulators in FSH and TGFbeta1 up-regulation of steroidogenic gene expression. Primary culture of ovarian granulosa cells from antral follicles of gonadotropin-primed immature rats was used. Interestingly, a selective ERalpha antagonist methyl-piperidino-pyrazole (MPP) [like ER antagonist ICI-182,780 (ICI)] decreased FSH +/- TGFbeta1-stimulated progesterone production, whereas an androgen receptor antagonist hydroxyflutamide and particularly a selective ERbeta antagonist 4-[2-Phenyl-5,7-bis(trifluoromethyl) pyrazolo [1,5-a] pyrimidin-3-yl] phenol had no significant effect. Consistent with this, a selective ERbeta agonist diarylpropionitrile (unlike 17beta-estradiol) also had no effect on FSH +/- TGFbeta1-stimulated progesterone production. Furthermore, a selective ERalpha agonist 4,4',4''-(4-Propyl-[1H]-pyrazole ...

Source: www.ncbi.nlm.nih.gov --- 9 days ago
Related Articles Estrogen prevents intestinal inflammation after trauma-hemorrhage via downregulation of angiotensin II and angiotensin II subtype I receptor. Am J Physiol Gastrointest Liver Physiol. 2008 Oct 2; Authors: Chen J, Yang S, Hu S, Choudhry MA, Bland KI, Chaudry IH Although angiotensin II (Ang II) plays a key role in development of organ ischemia-reperfusion injury, it remains unclear whether it is involved in development of intestinal injury following trauma-hemorrhage (T-H). Studies have shown that 17beta-estradiol (E2) administration following T-H improves small intestinal blood flow; however, it is unclear whether Ang II plays a role in this E2-mediated salutary effect. Male Sprague-Dawley rats underwent laparotomy and hemorrhagic shock (removal of 60% total blood volume, fluid resuscitation after 90 min). At onset of resuscitation, rats were treated with vehicle, E2, or E2 and Estrogen receptor antagonist ICI 182,780 (ICI). A separate group of rats was treated with Ang II subtype-I receptor (AT1R) antagonist Losartan. At 24 hr after T-H, plasma Ang II, interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha levels, small intestine Ang II, IL-6, TNF-alpha, intercellular adhesion molecule (ICAM)-1, cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-3 levels, myeloperoxidase (MPO) activity and AT1R expression were determined. T-H significantly increased plasma and intestinal Ang II, IL-6, and TNF-alpha levels, ...

Source: www.ncbi.nlm.nih.gov --- 9 days ago
Related Articles Regulation of vascular smooth muscle cell expression and function of matrix metalloproteinases is mediated by Estrogen and progesterone exposure. J Vasc Surg. 2008 Sep 30; Authors: Grandas OH, Mountain DH, Kirkpatrick SS, Cassada DC, Stevens SL, Freeman MB, Goldman MH OBJECTIVE: Postmenopausal women receiving hormone replacement therapy (HRT) have been reported to have more adverse outcomes after vascular reconstructions, including increased intimal hyperplasia development and bypass graft failure. HRT may be affecting the pathway contributing to intimal hyperplasia. An important component of this pathway involves matrix metalloproteinases (MMPs), implicated in vascular remodeling due to their ability to degrade components of the extracellular matrix. We hypothesize that Estrogen (Est) and progesterone (Prog) upregulate the MMP pathway in vascular smooth muscle cells (VSMCs) thereby increasing MMP activity and function. METHODS AND RESULTS: VSMCs were incubated with Est (5 ng/mL), Prog (50 ng/mL), Est + Prog combination (Est/Prog), and/or doxycycline (40 mug/mL; Doxy). Using reverse transcriptase polymerase chain reaction (RT-PCR) analysis we have previously shown membrane type 1-MMP (MT1-MMP) messenger ribonucleic acid (mRNA) levels are significantly increased by Est. Here, Western blot analyses indicated MT1-MMP and MMP-2 protein levels, not tissue inhibitor of MMP-2 (TIMP-2), were increased in response to Est and Es ...

Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles Estrogen receptor beta displays cell cycle-dependent expression and regulates the G1 phase through a non-genomic mechanism in prostate carcinoma cells. Cell Oncol. 2008;30(4):349-65 Authors: Hurtado A, Pinós T, Barbosa-Desongles A, López-Avilés S, Barquinero J, Petriz J, Santamaria-Martínez A, Morote J, de Torres I, Bellmunt J, Reventós J, Munell F BACKGROUND: It is well known that estrogens regulate cell cycle progression, but the specific contributions and mechanisms of action of the Estrogen receptor beta (ERbeta) remain elusive. METHODS: We have analyzed the levels of ERbeta1 and ERbeta2 throughout the cell cycle, as well as the mechanisms of action and the consequences of the over-expression of ERbeta1 in the human prostate cancer LNCaP cell line. RESULTS: Both ERbeta1 mRNA and protein expression increased from the G1 to the S phase and decreased before entering the G2/M phase, whereas ERbeta2 levels decreased during the S phase and increased in the G2/M phase. ERbeta1 protein was detected in both the nuclear and non-nuclear fractions, and ERbeta2 was found exclusively in the nucleus. Regarding the mechanisms of action, endogenous ERbeta was able to activate transcription via ERE during the S phase in a ligand-dependent manner, whereas no changes in AP1 and NFkappaB transactivation were observed after exposure to estradiol or the specific inhibitor ICI 182,780. Over-expression of either wild type ERbeta1 or ERbet ...

Source: www.ncbi.nlm.nih.gov --- 4 days ago
20 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Estrogen These PubMed results were generated on 2008/10/08 PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. ...

Source: www.moreover.com --- 29 days ago
MedWire News: Postmenopausal use of Estrogen, selective Estrogen receptor modulators (SERMs), or over-the-counter hormone preparations may increase the risk for gastroesophageal reflux disease (GERD), research indicates. ...

Source: www.moreover.com --- 24 days ago
Montreal -- The St. Lawrence River near Montreal has alarmingly high levels of Estrogen that is mutating male fish, University of Montreal researchers said. Sebastien Sauve, a professor of environmental chemistry, told the Canadian Broadcasting Corp. ...

Source: www.reuters.com --- 28 days ago
WASHINGTON (Reuters) - Estrogen creams do not help reduce wrinkles, especially those caused by the sun, researchers reported on Monday. ...

Source: www.boston.com --- 42 days ago
AGING Menopausal women often complain of memory problems. Since Estrogen levels plummet following menopause, one theory holds that Estrogen normally helps with memory formation. Mice injected with Estrogen, for example, perform better at memory-related tasks, like navigating through a maze or recognizing objects. But so far, its been unclear how Estrogen acts chemically in the brain. Now, research from the ... ...

Source: www.cbc.ca --- 25 days ago
Scientists have noticed some disturbing changes in the water, and the reproductive organs of fish, in the St. Lawrence River near Montreal. ...

Source: www.medicinenet.com --- 26 days ago
Title: Estrogen Cream No Match for Sun-Damaged Skin Category: Health News Created: 9/17/2008 2:00:00 AM Last Editorial Review: 9/17/2008 ...

Source: www.medicalnewstoday.com --- 25 days ago
Treating the skin with Estrogen can stimulate collagen production - which improves the appearance of the skin - in areas not typically exposed to the sun, according to new research from the University of Michigan Health System. But in sun-damaged skin, the same treatment does not increase collagen production, the study found. The findings elucidate why it is so difficult to reverse the effects of sun damage on the skin, says lead author Laure Rittie, Ph.D. ...