Deficits

Source: specialed.about.com --- 32 days ago
Strategies to support language Deficits - receptive. Special education support for comprehension and language difficulties. ...

Source: www.moreover.com --- 15 days ago
MedWire News: Neurocognitive Deficits in patients with bipolar disorder appear to be linked to increased homocysteine levels, with a stronger association in older patients and those with a delayed illness onset, international study findings indicate. ...

Source: www.ncbi.nlm.nih.gov --- 3 days ago
Related Articles Contrasting Deficits on executive functions between ADHD and reading disabled children. J Child Psychol Psychiatry. 2008 May;49(5):543-52 Authors: Marzocchi GM, Oosterlaan J, Zuddas A, Cavolina P, Geurts H, Redigolo D, Vio C, Sergeant JA BACKGROUND: The object of this study was to analyze the executive functioning of children with attention deficit hyperactivity disorder (ADHD) or reading disability (RD) independent of their non-executive Deficits. METHODS: Three carefully diagnosed groups of children, aged between 7 and 12 years (35 ADHD, 22 RD and 30 typically developing children), were tested on a wide range of tasks related to five major domains of executive functioning (EF): inhibition, visual working memory, planning, cognitive flexibility, and verbal fluency. Additional tasks were selected for each domain to control for non-executive processing. RESULTS: ADHD children were impaired on interference control, but not on prepotent and ongoing response suppression. ADHD showed Deficits on visual working memory, planning, cognitive flexibility and phonetic fluency. RD children were impaired on phonetic fluency. The only EF measure that differentiated ADHD from RD was planning. CONCLUSIONS: The present sample of ADHD children showed several EF Deficits, whereas RD children were almost spared executive dysfunction, but exhibited Deficits in phonetic fluency. PMID: 18400060 [PubMed - indexed for MEDLINE] ...

Source: www.ncbi.nlm.nih.gov --- 23 days ago
Related Articles The anthraquinone derivative Emodin ameliorates neurobehavioral Deficits of a rodent model for schizophrenia. J Neural Transm. 2008;115(3):521-30 Authors: Mizuno M, Kawamura H, Takei N, Nawa H Abnormality in cytokine signaling is implicated in the neuropathology of schizophrenia. Previously, we established an animal model for schizophrenia by administering epidermal growth factor (EGF) to neonatal rats. Here we investigated effects of the anthraquinone derivatives emodin (3-methyl-1,6,8-trihydroxyanthraquinone) and sennoside (bis-[D: -glucopyranosyl-oxy]-tetrahydro-4,4'-dihydroxy-dioxo[bianthracene]-2,2'-dicarboxylic acid) on behaviors of this model and EGF signaling. Subchronic oral administration of emodin (50 mg/kg) suppressed acoustic startle responses and abolished prepulse inhibition (PPI) Deficits in this rodent model. ANCOVA revealed that emodin had distinct effects on PPI and startle responses. In contrast, sennoside (50 mg/kg) had no effects. Emodin attenuated weight gain initially during treatment but had no apparent effect on weight gain and locomotor activity thereafter. Application of emodin to neocortical cultures attenuated the phosphorylation of ErbB1 and ErbB2. We conclude that emodin can both attenuate EGF receptor signaling and ameliorate behavioral Deficits. Therefore, emodin might be a novel class of a pro-drug for anti-psychotic medication. PMID: 18301953 [PubMed - indexed for MEDLINE] ...

Source: www.ncbi.nlm.nih.gov --- 23 days ago
Related Articles Neurocognitive Deficits in pediatric obstructive sleep apnea: A multifaceted pathogenetic model. Sleep Med. 2008 Jun 26; Authors: Bruni O, Ferri R PMID: 18585957 [PubMed - as supplied by publisher] ...

Source: www.ncbi.nlm.nih.gov --- 23 days ago
Related Articles Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive Deficits in mouse models of Down's syndrome. Proc Natl Acad Sci U S A. 2008 Jun 30; Authors: Voronov SV, Frere SG, Giovedi S, Pollina EA, Borel C, Zhang H, Schmidt C, Akeson EC, Wenk MR, Cimasoni L, Arancio O, Davisson MT, Antonarakis SE, Gardiner K, De Camilli P, Di Paolo G Phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P(2)] is a signaling phospholipid implicated in a wide variety of cellular functions. At synapses, where normal PtdIns(4,5)P(2) balance is required for proper neurotransmission, the phosphoinositide phosphatase synaptojanin 1 is a key regulator of its metabolism. The underlying gene, SYNJ1, maps to human chromosome 21 and is thus a candidate for involvement in Down's syndrome (DS), a complex disorder resulting from the overexpression of trisomic genes. Here, we show that PtdIns(4,5)P(2) metabolism is altered in the brain of Ts65Dn mice, the most commonly used model of DS. This defect is rescued by restoring Synj1 to disomy in Ts65Dn mice and is recapitulated in transgenic mice overexpressing Synj1 from BAC constructs. These transgenic mice also exhibit Deficits in performance of the Morris water maze task, suggesting that PtdIns(4,5)P(2) dyshomeostasis caused by gene dosage imbalance for Synj1 may contribute to brain dysfunction and cognitive disabilities in DS. PMID: 18591654 [PubMed - as supplied by publisher] ...

Source: www.moreover.com --- 24 days ago
A doctor testified yesterday about repairing injuries suffered by former Charger linebacker Steve Foley after he was shot two years ago by an off-duty Coronado police officer. Dr. ...

Source: www.ncbi.nlm.nih.gov --- 22 hours ago
Related Articles The loss of methyl-CpG binding protein 1 leads to autism-like behavioral Deficits. Hum Mol Genet. 2008 Jul 1;17(13):2047-57 Authors: Allan AM, Liang X, Luo Y, Pak C, Li X, Szulwach KE, Chen D, Jin P, Zhao X Methyl-CpG binding proteins (MBDs) are central components of DNA methylation-mediated epigenetic gene regulation. Alterations of epigenetic pathways are known to be associated with several neurodevelopmental disorders, particularly autism. Our previous studies showed that the loss of Mbd1 led to reduced hippocampal neurogenesis and impaired learning in mice. However, whether MBD1 regulates the autism-related cognitive functions remains unknown. Here we show that Mbd1 mutant (Mbd1(-/-)) mice exhibit several core Deficits frequently associated with autism, including reduced social interaction, learning Deficits, anxiety, defective sensory motor gating, depression and abnormal brain serotonin activity. Furthermore, we find that Mbd1 can directly regulate the expression of Htr2c, one of the serotonin receptors, by binding to its promoter, and the loss of Mbd1 led to elevated expression of Htr2c. Our results, therefore, demonstrate the importance of epigenetic regulation in mammalian brain development and cognitive functions. Understanding how the loss of Mbd1 could lead to autism-like behavioral phenotypes would reveal much-needed information about the molecular pathogenesis of autism. PMID: 18385101 [PubMed - indexed ...

Source: www.ncbi.nlm.nih.gov --- 14 days ago
Related Articles Long-term Deficits of preterm birth: evidence for arousal and attentional disturbances. Clin Neurophysiol. 2008 Jun;119(6):1281-91 Authors: Hall RW, Huitt TW, Thapa R, Williams DK, Anand KJ, Garcia-Rill E OBJECTIVE: Quantitative measures of pre-attentional, attentional and frontal lobe processes were compared to evaluate quantitative measures of these Deficits in Ex-Preterm vs. Ex-Term adolescents. METHODS: We compared 43 Ex-Preterm with 26 Ex-Term adolescents using the P50 auditory potential, the Psychomotor Vigilance Task (PVT), a reaction time (RT) test, and Near Infrared Spectroscopy (NIRS). RESULTS: The mean amplitude (+/-SE) of the P50 amplitude was similar in the Ex-Preterm (1.8+/-1.4 microV) vs. Ex-Term adolescents (1.8+/-0.6 microV, df = 68, F = 0.05, p = 0.8), but the Ex-Preterm group showed a trimodal distribution in amplitude (High, 3.3+/-0.4 microV, df=42.25, F=19.2, p < 0.01; Medium, 1.7+/-0.1 microV, df = 39, F = 0.41, p = 0.53; Low, 0.7+/-0.1 microV, df = 40, F = 49.5, p < 0.01) suggested by statistically significant variance between populations (Kolmogorov-Kuiper test, df = 42.25, F = 5.4, p < 0.01). Mean RT was longer in Ex-Preterm (250+/-8 ms) vs. Ex-Term subjects (200+/-5 ms, df = 68, F = 18.8, p < 0.001). PVT lapses were increased in Ex-Preterm subjects, and varied inversely with P50 amplitude (Overall Mean 17+/-5 lapses, df = 67, F = 5.34, p < 0.05; Low P50 amplitude, 25+/-10, df = 40, F = 8.8, p ...

Source: www.ncbi.nlm.nih.gov --- 17 days ago
Related Articles Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral Deficits in gerbils: comparison of pre- and post-ischemic administration. J Nutr Biochem. 2008 Jul 3; Authors: Wang Q, Sun AY, Simonyi A, Miller DK, Smith RE, Luchtefeld RG, Korthuis RJ, Sun GY Oxidative stress has been regarded as an important underlying cause for the delayed neuronal death (DND) after cerebral ischemia. In this study, the effects of short-term oral administration of grape polyphenol extract (GPE) on ischemia/reperfusion (I/R) injury in a gerbil global ischemia model were determined. Ischemia was induced by occlusion of the common carotid arteries for 5 min. GPE (30 mg/ml)-containing formula or formula without GPE was administered daily via gavage for 4 days prior to and/or for 4 days after I/R. I/R resulted in hyperlocomotion, extensive DND, oxidative and fragmented DNA damage, and an increase in reactive astrocytes and microglial cells in the hippocampal CA1 region. GPE administration for 4 days prior to I/R and for 4 days after I/R attenuated DND, DNA damage and glial cell activation. However, neuroprotection was more pronounced when GPE was administered for 4 days after I/R than when administered for 4 days prior to I/R. GPE administration after I/R attenuated I/R-induced hyperlocomotion. These findings indicate that oral GPE intake may confer protection against I/R injur ...

Source: www.ncbi.nlm.nih.gov --- 2 days ago
Related Articles Combined lithium and valproate treatment delays disease onset, reduces neurological Deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model. Neuroscience. 2008 Jun 21; Authors: Feng HL, Leng Y, Ma CH, Zhang J, Ren M, Chuang DM Lithium and valproic acid (VPA) are two primary drugs used to treat bipolar disorder, and have been shown to have neuroprotective properties in vivo and in vitro. A recent study demonstrated that combined treatment with lithium and VPA elicits synergistic neuroprotective effects against glutamate excitotoxicity in cultured brain neurons, and the synergy involves potentiated inhibition of glycogen synthase kinase-3 (GSK-3) activity through enhanced GSK-3 serine phosphorylation [Leng Y, Liang MH, Ren M, Marinova Z, Leeds P, Chuang DM (2008) Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition. J Neurosci 28:2576-2588]. We therefore investigated the effects of lithium and VPA cotreatment on the disease symptom onset, survival time and neurological Deficits in cooper zinc superoxide dismutase (SOD1) G93A mutant mice, a commonly used mouse model of amyotrophic lateral sclerosis (ALS). The G93A ALS mice received twice daily i.p. injections with LiCl (60 mg/kg), VPA (300 mg/kg) or lithium plus VPA, starting from the 30(th) day after birth and continuing until death. We fo ...

Source: www.ncbi.nlm.nih.gov --- 15 days ago
Related Articles Working memory in school-aged children with attention-deficit/hyperactivity disorder combined type: Are Deficits modality specific and are they independent of impaired inhibitory control? J Clin Exp Neuropsychol. 2008 Feb 4;:1-11 Authors: Brocki KC, Randall KD, Bohlin G, Kerns KA This study examines differences between children with attention-deficit/ hyperactivity disorder combined type (ADHD-C) and normal controls on verbal and visuospatial working-memory (WM) tasks. The extent to which WM Deficits in children with ADHD-C are independent of impaired inhibitory control was also examined. Two groups of 7- to 12-year-old boys participated in this study. The first group included 31 boys diagnosed with ADHD-C, and the second group included 34 boys without ADHD. Various verbal and visuospatial WM tasks and two inhibitory control tasks-prepotent response inhibition and interference control-were used. Overall, our results suggest impaired verbal and visuospatial WM processes in children with ADHD-C, as well as a lower level of performance on prepotent response inhibition. WM Deficits in ADHD have previously been suggested to be particularly salient in the spatial domain; our results instead showed the largest effect for a verbal WM task thought to put heavy load on the executive or attentional control component of the WM system. An interpretation of this finding is that it is variation in terms of difficulty level or load on ...

Source: www.marketwatch.com --- 22 days ago
The two presidential candidates spend a lot of time chastising us for our “addiction to oil,” warning that our dependence on foreign oil threatens our energy security, but they don't say much about our other equally harmful addiction -- budget Deficits. ...

Source: www.canada.com --- 7 days ago
CALGARY - New documents reveal the Alberta government paid more than $60 million last year to cash-strapped health regions, and taxpayers are still facing a tab of nearly $100 million to cover Deficits at the former health authorities. ...

Source: www.moreover.com --- 4 days ago
Roll Call Online Jul 21 2008 5:19AM GMT ...

Source: www.detnews.com --- 49 days ago
Facing a $1.1 million budget deficit and declining enrollment, Fowlerville Community Schools will consider realigning schools for kindergarten through eighth-grade students. ...

Source: clientportal.ibb.ubs.com --- 28 days ago
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Source: blog.oregonlive.com --- 31 days ago
TACOMA, Wash. - Matt Antonelli's sacrifice fly plated the go-ahead run and Chip Ambres added a two-run homer in the three-run ninth inning as the Portland Beavers overcame two different Deficits to complete an 8-5 comeback over the Tacoma Rainiers... ...

Source: www.articlealley.com --- 9 days ago
Cash loans are best option to fulfill the unexpected emergency needs of the borrower. These loans are designed in such a way that borrowers can avail them when they need money but can not arrange it. There are three types of these loans available in t... ...

Source: www.thisismoney.co.uk --- 2 days ago
There has been much gnashing of teeth over the last few days about Alistair Darling's willingness to ditch the fiscal rules in the face of the sharp slowdown in the economy ...