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Source: www.techeye.net --- 50 seconds ago
New research by British and US scientists has seen repair proteins appear to jump between DNA molecules and sliding across strands to fix mistakes, like ‘jumping fleas’. Boffins at the University of Essex in the UK as well as Pittsburgh and Vermont in the US discovered this tagging proteins with quantum dots, reporting the findings in Molecular Cell . The aim of the research was to discover how a repair system worked rapidly to maintain the integrity of DNA code sequences, which were constantly being bombarded with environmental toxins. Bennett Van Houten, professor of pharmacology and chemical biology at the University of Pittsburgh, said that the way the repair system worked was an important unanswered question in the field. He said: “It has to be able to identify very small mistakes in a three-dimensional morass of gene strands. It is akin to spotting potholes on every street all over the country and getting them fixed before the next rush hour.” Two repair proteins (UvrA and UvrB) were tagged with quantum dots, which are semiconductor nanocrystals that light up in different colours. The clumped DNA was also stretched into ‘tightropes’ to see the process clearly. UvrA proteins jumped from one DNA molecule to the next, staying for about seven seconds before going on to the next one. But when a UvrA molecule formed a complex with two UvrB molecules (UvrAB), this searched more efficiently by sliding along the DNA for as long as 40 s ... Source: www.ncbi.nlm.nih.gov --- 16 minutes ago
Related Articles Regulation of Inter- and Intramolecular Interaction of RNA, DNA, and Proteins by MLE. Methods Mol Biol. 2010;587:303-26 Authors: Oh H, Parrott AM, Park Y, Lee CG Drosophila maleless (MLE) is a member of helicase superfamily 2 and functions as a dosage compensation factor essential for the development of male flies. This function provides a good opportunity to investigate diverse biochemical activities associated with MLE in the context of a defined in vivo pathway, i.e., the transcriptional activation of X-linked genes. We have shown for the first time that MLE catalyzes the unwinding of both DNA and RNA and that MLE helicase activity is essential for its in vivo function. Also, we have provided evidence that MLE stimulates the transcriptional activity of roX2 on the X chromosome. We have also found that MLE interacts with dsDNA, topoisomerase II, and nucleosome. This observation supports a current model of dosage compensation: transcriptional activation of X-linked genes is causally associated with conformational change in the male X chromosome, subsequent to the targeted association of the dosage compensation complex (DCC). PMID: 20225159 [PubMed - in process] ... Source: madville.com --- 34 minutes ago
Once again President Barack Obama is not the civil-liberties knight in shining armor ... Source: blogs.zdnet.com --- 50 minutes ago
President Obama was asked if a DNA database should be created upon arrest of an individual. President Obama agrees such as database needs to be created and needs funding. ...
Source: blog.cleveland.com --- 1 hour ago
Scott had raped her with a Colt 45 beer bottle, hog-tied her, stuffed a sock in her mouth and taped it shut, wrapped a rope around her neck, duct-taped her wrists behind her back and wrapped her in a white sheet. He then put her in a green garbage bag. ... Source: www.theatlanticwire.com --- 1 hour ago
Can sampling DNA at birth fight crime? Share Your Genes Michael Seringhaus , The New York Times ... Source: tnc-worldphotos.blogspot.com --- 3 hours ago
By Cleo Patek Robinson To some groups of people, like Native Americans, DNA testing is used not only to establish links to ancestors but also to determine legal rights and privileges. Tribal sovereignty and legal rights are hot topics of discussion in American political arenas and are disputed in the courts all the time. States, industries and land owners themselves challenge the tribes' rights to govern their own lands and people, or to even exist at all. Most citizens do not even realize that tribes are political entities unto themselves and not just quaint little ethnic groups. And because of the legal protections afforded Native Americans, DNA testing often becomes necessary for them to be able to prove their ancestry and enjoy the rights and privileges that their tribes have earned. Because federal laws and tribal laws focus on the tribes relating as a group, their cultural continuity and their tribal land-base, many people who have Native American biological ancestors are unfortunately ineligible for federally recognized tribal status because they either don't live with the tribe, do not function with the tribe or their heritage has become mixed. DNA testing is usually the sole recourse these Native Americans have if they want to be legally recognized as a tribal member. Without this recognition, they will lose access to land, financial aid and even gaming business licenses. Some people even recommend that DNA testing become a ... Source: auntygravity.blogspot.com --- 3 hours ago
By David Kravets Josh Gerstein over at Politico sent Threat Level his piece underscoring once again President Barack Obama is not the civil-liberties knight in shining armor many were expecting. Gerstein posts a televised interview of Obama and John Walsh of America’s Most Wanted. The nation’s chief executive extols the virtues of mandatory DNA testing of Americans upon arrest, even absent charges or a conviction. Obama said, “It’s the right thing to do” to “tighten the grip around folks” who commit crime. When it comes to civil liberties, the Obama administration has come under fire for often mirroring his predecessor’s practices surrounding state secrets , the Patriot Act and domestic spying . There’s also Gitmo , Jay Bybee and John Yoo . Now there’s DNA sampling. Obama told Walsh he supported the federal government, as well as the 18 states that have varying laws requiring compulsory DNA sampling of individuals upon an arrest for crimes ranging from misdemeanors to felonies. The data is lodged in state and federal databases, and has fostered as many as 200 arrests nationwide, Walsh said. The American Civil Liberties Union claims DNA sampling is different from mandatory, upon-arrest fingerprinting that has been standard practice in the United States for decades. A fingerprint, the group says, reveals nothing more than a person’s identity. But much can be learned from a DNA sample, which codes a person’s family ties, some health ris ... Source: supportyourlocalgunfighter.com --- 3 hours ago
Oh, this isn’t just for felonies like murder and rape. The president wants law enforcement to take DNA samples from every person arrested for every crime – even if there is not a conviction. Barack Hussein Obama, taking a dump on the Constitution. Josh Gerstein over at Politico sent Threat Level his piece underscoring once again [...] ... Source: www.hooping.org --- 5 hours ago
What happens when you put Shakti Sunfire, Rich Porter, Spiral, Shredder and Brecken Rivara on the same stage? It took place at DNA Lounge in San Francisco, California. Video by Sharka HolyStrawberry.... ...
Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling
Source: www.moreover.com --- 6 hours ago
Journal of Cellular and Molecular Medicine Mar 15 2010 7:50AM GMT ... Source: app.feed.informer.com --- 6 hours ago
DNA GROUP: New Media Communications Manager Competitive package: DNA Group: Leading Global Private Energy Trading House seeks digital communications savvy specialist to become New Media Communications Manager. London Job Details Tweet This! Share this on del.icio.us Share this on Facebook Share this on Linkedin Digg this! Stumble upon something good? Share it on StumbleUpon Add this to Google Bookmarks Share this on Reddit Blog this on Blogger Post this to Posterous ... Source: www.uncommondescent.com --- 7 hours ago
The heroics of the cell’s DNA repair system are well known , but new research is adding yet another incredible facet to the story. Experimentalists tagged DNA repair proteins with nanocrystals that light up. They then observed how they interact with DNA molecules. As reported : Read more Copyright © 2010 Uncommon Descent . This Feed is for personal non-commercial use only. If you are not reading this material in your news aggregator, the site you are looking at is guilty of copyright infringement. Please contact legal@www.uncommondescent.com so we can take legal action immediately. Plugin by Taragana ...
Source: www.moreover.com --- 8 hours ago
DNA vaccines ensure protective immunity against tumors in a variety of experimental models. The favorite target tumor-associated antigens have been those that are frequently expressed by human tumors, such as Her2. ... Source: www.politics.com --- 9 hours ago
"It's the right thing to do". Really? What of this Right to Privacy we heard so much about? We terminate generations in it's name , but we invoke morality when the time comes to compile the most personal data we possess? These people are lawless, and must be rejected at the ballot box lest their usurpations become more severe. Evidence of their abuse is leigon;... ... Source: www.drudgereportarchives.com --- 10 hours ago
... Source: www.geospiza.com --- 11 hours ago
ABRF 2010 is next week. The conference will be in sunny Sacramento CA. About 1000 technology geeks will convene to learn about the latest advances in DNA sequencing, genotyping, and proteomics... ... |
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