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Source: www.ncbi.nlm.nih.gov --- 4 days ago
Related Articles [Efficacy, impact on survival and cost of intensive follow-up after curative resection for Colorectal Cancer aim] Ann Ital Chir. 2008 Jan-Feb;79(1):1-12 Authors: Cola B, Cuicchi D, Lecce F, Lombardi R, Ciaroni V, Dalla Via B AIM OF THE STUDY: This retrospective study was aimed at establishing the efficacy, impact on survival and cost of an intensive follow-up program. METHODS: Data from 790 patients who underwent resections for primary Colorectal carcinoma were prospectively entered into a data-base. Four hundred fifty-six patients who had radical surgery were followed-up with a 5-year preestablished schedule. Median follow-up was 42 months (range 2-108). RESULTS: Seventy-four adenomas, 7 metachronous carcinomas, 11 extra-colonic carcinomas and 96 recurrences (13 locoregional recurrences, 68 metastases and 15 cases of combined recurrences) were detected. Thirty-eight (39.6%) of 96 recurrences were amenable to salvage therapy and 23 relapses (24.0%) were radically resected. The median survival of patients who had recurrences was 38 months. The 5-year overall survival was significantly better in patients underwent radical surgery than those who were not treated with curative resection (60.0% vs 7.5%, p < 0.0001). Radical re-operations were performed in 2 (4.8%) of the 42 symptomatic patients and in 21 (38.9%) of the 54 cases with asymptomatic relapses. Median overall survival of patients with asymptomatic recurrences wa ... Source: www.ncbi.nlm.nih.gov --- 1 day ago
Screening Guidelines for Colorectal Cancer: A Twice-Told Tale. Ann Intern Med. 2008 Oct 7; Authors: Pignone M, Sox HC PMID: 18840787 [PubMed - as supplied by publisher] ... Source: www.moreover.com --- 6 days ago
Stool DNA and computed tomographic colonography (CTC) are now officially endorsed, albeit with some limitations, as standards for Colorectal Cancer screening, according to updated guidelines jointly issued by the American Cancer Society, the American ... Source: www.ncbi.nlm.nih.gov --- 2 days ago
Related Articles Host-related predictive factors for anastomotic leakage following large bowel resections for Colorectal Cancer. J Gastrointestin Liver Dis. 2008 Sep;17(3):299-303 Authors: Iancu C, Mocan LC, Todea-Iancu D, Mocan T, Acalovschi I, Ionescu D, Zaharie FV, Osian G, Puia CI, Muntean V AIM. To identify the risk, the host-related prognostic factors and their predictive value for anastomotic leakage after Colorectal resections following Cancer. METHOD. 993 patients who underwent large bowel resection and primary anastomosis above 12 centimeters from the anal verge, without a temporary or permanent stoma at the Surgical Hospital No.3 (Cluj-Napoca, Romania) were retrospectively reviewed. RESULTS. 32 (3.22 percent) anastomotic leaks were confirmed. Univariate analysis showed that the preoperative variables significantly associated with anastomotic leakage included: weight loss, smoking, cardiovascular disease, lung disease, hypoproteinemia, diabetes, anemia, leukocytosis, presence of two or more underlying diseases. Alcohol use, cerebrovascular disease, bowel preparation, type of anastomosis, tumor location, stage and histology were not significant variables. Hypoproteinemia (total serum protein level ≤ 6 g/dl) and anemia (serum hemoglobin level ≤ 11 g/dl) remained significant in the logistic regression model. The prognostic role of serum hemoglobin and proteins for the anastomotic leak was assessed using ROC curve analysis. ... Source: www.ncbi.nlm.nih.gov --- 8 days ago
Related Articles Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and Colorectal Cancer risk. JAMA. 2008 Oct 1;300(13):1523-31 Authors: Kaklamani VG, Wisinski KB, Sadim M, Gulden C, Do A, Offit K, Baron JA, Ahsan H, Mantzoros C, Pasche B CONTEXT: Current epidemiological evidence suggests an association between obesity, hyperinsulinemia, and Colorectal Cancer risk. Adiponectin is a hormone secreted by the adipose tissue, and serum levels are inversely correlated with obesity and hyperinsulinemia. While there is evidence of an association between circulating adiponectin levels and Colorectal Cancer risk, no association between genes of the adiponectin pathway and Colorectal Cancer have been reported to date. OBJECTIVE: To determine the association of 10 haplotype-tagging single-nucleotide polymorphisms (SNPs) of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes with Colorectal Cancer risk. DESIGN, SETTING, AND PATIENTS: Two case-control studies including patients with a diagnosis of Colorectal Cancer and controls were recruited between 2000 and 2007. Case-control study 1 included a total of 441 patients with a diagnosis of Colorectal Cancer and 658 controls; both groups were of Ashkenazi Jewish ancestry and from New York, New York. Case-control study 2 included 199 patients with a diagnosis of Colorectal Cancer and 199 controls from Chicago, Illinois, matched 1:1 for sex, age, and ethnici ... Source: www.ncbi.nlm.nih.gov --- 6 days ago
Related Articles Bevacizumab in advanced Colorectal Cancer: a challenge to the current paradigm. J Clin Oncol. 2008 Oct 1;26(28):4693-4; author reply 4694-5 Authors: Booth C PMID: 18824719 [PubMed - in process] ... Source: www.ncbi.nlm.nih.gov --- 10 hours ago
Related Articles Prospective relationships of physical activity with quality of life among Colorectal Cancer survivors. J Clin Oncol. 2008 Sep 20;26(27):4480-7 Authors: Lynch BM, Cerin E, Owen N, Hawkes AL, Aitken JF PURPOSE: Physical activity can enhance quality of life for Cancer survivors. However, few longitudinal studies have examined whether physical activity has a sustained effect on improvements in quality of life. The present study aims to examine the relationships between physical activity and quality of life over 2 years after a Colorectal Cancer diagnosis. PATIENTS AND METHODS: Data were collected within the Colorectal Cancer and Quality of Life Study, in which 1,966 people diagnosed with Colorectal Cancer were recruited through the Queensland Cancer Registry. Participants completed telephone interviews at approximately 6, 12, and 24 months after diagnosis. Generalized linear mixed models were used to estimate the overall, interindividual, and intraindividual level independent effects of participation in physical activity on quality of life. RESULTS: There was an overall independent association between physical activity and quality of life. At a given time point, participants achieving at least 150 minutes of physical activity per week had an 18% higher quality of life score than those who reported no physical activity. Significant associations were also present at the interindividual level (differences between participan ... Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles Clinico-Pathological and Prognostic Significance of p53, Bcl-2 and Her-2/neu Protein Markers in Colorectal Cancer Using Tissue Microarray. J Egypt Natl Canc Inst. 2007 Mar;19(1):3-14 Authors: Ismail HM, El-Baradie M, Moneer M, Khorshid O, Touny A Background: The prognostic role of her-2/neu has been established in breast Cancer but remains controversial in Colorectal Cancer (CRC). Widespread genetic mutations in Colorectal carcinogenesis exist on chromosome 17. Her- 2/neu gene and the tumor suppressor gene p53 are both located on this chromosome. Bcl-2 protein prolongs survival of a variety of cells by blocking apoptosis. The aim of this study is to evaluate the relationship between the overexpression of p53, bcl-2 and her-2/neu protein markers and the clinico-pathologic characteristics of CRC, and their influence on survival rates. Patients and Methods: One hundred and four cases of CRC had paraffin blocks with representative tissue, and sufficient follow-up data. They were arrayed and evaluated for protein marker expression using tissue microarray (TMA). Results: Ten (9.6%), 35 (33.7%) and 27 (26%) of the patients were her-2/neu, p53 and bcl-2 positive, respectively. None of the examined clinico-pathologic factors had a significant relation with her-2/neu overexpression. Patients with +ve bcl-2 had a significantly higher mean age (52.4-/+13.3years) compared to 45.4-/+14.4 years for bcl-2 negative patients, p=0.03. Po ... Source: www.moreover.com --- 6 days ago
Philippine Star Oct 5 2008 12:42AM GMT ... Source: www.medicalnewstoday.com --- 18 hours ago
Biothera announced today that it completed enrollment in the first arm of its metastatic Colorectal Cancer (mCRC) trial in July. The dual-arm trial is evaluating the combination therapy of Imprime PGG®, the company's lead drug candidate, and Erbitux® (cetuximab), a monoclonal antibody from ImClone Systems, with or without chemotherapy. ... Source: www.medicalnewstoday.com --- 3 days ago
In a change from its previous recommendation, the U.S. Preventive Services Task Force now recommends that adults age 50 to 75 be screened for Colorectal Cancer using annual high-sensitivity fecal occult blood testing, sigmoidoscopy every five years with fecal occult testing between sigmoidoscopic exams, or colonoscopy every 10 years. According to the Task Force, good evidence exists that using these methods save lives. ... Source: www.medicalnewstoday.com --- 8 days ago
Variation of a gene for a protein hormone that is secreted by fat cells is associated with a decreased Colorectal Cancer risk, according to a study in the October 1 issue of JAMA. Several studies have shown an association between obesity and the risk of Colorectal Cancer, according to background information in the article. Adiponectin is a hormone secreted by fat tissue, and serum levels of adiponectin are inversely correlated with obesity and high levels of insulin. ... Source: www.medicalnewstoday.com --- 5 days ago
Incidence reduction in the proximal colon differs in magnitude and timing Patients who undergo a complete negative colonoscopy have a reduced incidence of Colorectal Cancer, confirms a study published in Clinical Gastroenterology and Hepatology. However, in the proximal colon, the incidence reduction of Colorectal Cancer following complete negative colonoscopy differs in magnitude and timing. ... Source: jama.ama-assn.org --- 9 days ago
Context Current epidemiological evidence suggests an association between obesity, hyperinsulinemia, and Colorectal Cancer risk. Adiponectin is a hormone secreted by the adipose tissue, and serum levels are inversely correlated with obesity and hyperinsulinemia. While there is evidence of an association between circulating adiponectin levels and Colorectal Cancer risk, no association between genes of the adiponectin pathway and Colorectal Cancer have been reported to date. Objective To determine the association of 10 haplotype-tagging single-nucleotide polymorphisms (SNPs) of the adiponectin ( ADIPOQ ) and adiponectin receptor 1 ( ADIPOR1 ) genes with Colorectal Cancer risk. Design, Setting, and Patients Two case-control studies including patients with a diagnosis of Colorectal Cancer and controls were recruited between 2000 and 2007. Case-control study 1 included a total of 441 patients with a diagnosis of Colorectal Cancer and 658 controls; both groups were of Ashkenazi Jewish ancestry and from New York, New York. Case-control study 2 included 199 patients with a diagnosis of Colorectal Cancer and 199 controls from Chicago, Illinois, matched 1:1 for sex, age, and ethnicity. Main Outcome Measures ADIPOQ and ADIPOR1 SNP frequency among cases and controls. Results In study 1, after adjustment for age, sex, and SNPs from the same gene, 3 ADIPOQ SNPs and 1 ADIPOR1 SNP were associated with Colorectal Cancer risk: rs266729 (adjuste ... Source: www.medicalnewstoday.com --- 5 days ago
Amgen Belgium announces the availability of Vectibix® (panitumumab), the first fully human anti-EGFR monoclonal antibody indicated as monotherapy for the treatment of patients with epidermal growth factor receptor (EGFR)-expressing metastatic Colorectal Cancer (mCRC) with non-mutated (wild-type) KRASgene after failure of fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy protocols. ... Source: www.medicalnewstoday.com --- 8 days ago
DNA Direct, Inc. announced that the company will offer ColoSure(TM), a state of the art, safe, simple, and convenient test to screen for colon Cancer -- the second leading cause of Cancer-related deaths in the United States. ColoSure tests a single stool sample for a DNA marker associated with Colorectal Cancer, and may be ordered through DNA Direct's website at http://www.dnadirect.com. ... Source: www.moreover.com --- 9 days ago
Medical News Today Oct 1 2008 9:47AM GMT ... Source: www.moreover.com --- 4 days ago
EurekAlert! Oct 6 2008 12:56PM GMT ... Source: www.medicalnewstoday.com --- 3 days ago
In a large U.S. population-based study presented at the 73rd Annual Scientific Meeting of the American College of Gastroenterology, metabolic syndrome patients had a 75 percent higher risk of Colorectal Cancer compared to those without metabolic syndrome. Dr. Donald Garrow and Dr. ... Source: www.medicalnewstoday.com --- 8 days ago
Research out of Wake Forest University School of Medicine suggests that a surgical technique not traditionally used in advanced abdominal Cancer may be a viable treatment option for some patients previously thought to be untreatable, offering the real possibility of extending survival for those patients. ... Find more results for Colorectal Cancer on RSSMicro.com |
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