Cardiomyopathy

Source: www.ncbi.nlm.nih.gov --- 8 days ago
Related Articles Transplantation of allogenic cells in the therapy of patients with dilated Cardiomyopathy. Bull Exp Biol Med. 2007 Oct;144(4):635-9 Authors: Kirillov AM, Fatkhudinov TKh, Dyachkov AV, Koroteev AV, Goldshtein DV, Bochkov NP We carried out a pilot study on intracoronary transplantation of prenatal allogenic skeletal myoblasts and multipotent bone marrow stromal cells to patients with dilated Cardiomyopathy. Intracoronary transplantation of allogenic cells is a feasible and safe procedure: there were no life-threatening rhythm and conduction disturbances, symptoms of hemodynamic instability, and thromboembolic complications. Positive clinical effect of cell transplantation persisted for 6 months and consisted in decreased content of brain natriuretic peptide and improved tolerance to physical exercises. We observed no reliable dynamics of the major echocardiographic parameters and their correlations with patient's status. PMID: 18642728 [PubMed - indexed for MEDLINE] ...

Source: www.ncbi.nlm.nih.gov --- 8 days ago
Related Articles Safe use of efalizumab in a psoriasis patient with chronic heart failure due to hypertrophic Cardiomyopathy. G Ital Dermatol Venereol. 2008 Apr;143(2):167 Authors: Cassano N, Miracapillo A, Buquicchio R, Mastrandrea V, Vena GA PMID: 18833044 [PubMed - in process] ...

Source: www.moreover.com --- 4 days ago
Belardinelli R et al. - The addition of TMZ to ET determined greater improvements in functional capacity, left ventricular ejection fraction, and endothelium-dependent dilation than TMZ or ET given alone. ...

Source: www.ncbi.nlm.nih.gov --- 4 days ago
Related Articles Prognostic performance of quantitative PET tools for stratification of patients with ischemic Cardiomyopathy undergoing myocardial viability assessment. Nucl Med Commun. 2008 Nov;29(11):970-81 Authors: Santana CA, Faber TL, Soler-Peter M, Sanyal R, Esteves FP, Ornelas M, Folks RD, Verdes L, Santana LF, Candell-Riera J, Garcia EV OBJECTIVES: This study was performed to determine the prognostic performance of quantitative PET tools in the stratification of patients with ischemic Cardiomyopathy undergoing myocardial viability assessment. METHODS: We applied four different quantitative tools to 104 consecutive patients with coronary artery disease and previous myocardial infarction who had undergone rest Rb/gated F-fluorodeoxyglucose (FDG) PET, to assess myocardial viability for potential revascularization. One of these tools was based on the FDG study alone and the other three tools assessed the extent of match/mismatch defects using FDG in comparison with a perfusion reference database. The four quantitative tools used in this research to define viability were (i) FDG alone, which calculates the percentage of left ventricular myocardium (LVM) that is above the 50% of the maximum LVM FDG counts, (ii) low flow match/mismatch, which determines the area with a 5% increase in normalized FDG counts in relation to defined resting perfusion defects as compared with a reference database, (iii) all regions match/mismatch, which co ...

Source: www.ncbi.nlm.nih.gov --- 2 days ago
Related Articles Effect of cell-free DNA of patients with Cardiomyopathy and rDNA on the frequency of contraction of electrically paced neonatal rat ventricular myocytes in culture. Ann N Y Acad Sci. 2008 Aug;1137:273-7 Authors: Bulicheva N, Fidelina O, Mkrtumova N, Neverova M, Bogush A, Bogush M, Roginko O, Veiko N There is evidence that infarcted myocardium contributes to the increase of cell-free DNA levels (cfDNA). We studied the effect of different human DNA fragments on the rate of contraction of the electrically paced neonatal rat ventricular myocytes in culture (spontaneously hypertensive line SHR). AT-rich fragments of the human satellite 3 tandem repeat (1q12 region) at a concentration of 1 ng/mL increase the frequency of cardiomyocyte contractions by 2-2.5 times. GC-rich fragments of the rDNA at 0.5 ng/mL decrease the cardiomyocyte contraction frequency by 1.5-2 times. The serum cfDNA of patients with acute myocardial infarction decreases the frequency of the contraction of cardiomyocytes proportionally to the amount of the rDNA fragments it contains. The rDNA effect is similar to the E. coli DNA effect and is presumably being realized through TLR9. In the presence of the inhibitor of these receptors, rDNA operates the same way as the fragment of the satellite 3-increasing the frequency of the cardiomyocyte contractions. Accumulation of the GC-rich fragments of the cfDNA in the blood of the AMI patients might have an influe ...

Source: www.moreover.com --- 16 days ago
Tourneau TL et al. - In obstructive HCM, VWF impairment is frequent and is closely and independently related to the magnitude of outflow obstruction. A resting peak gradient of 15 mm Hg is sufficient to impair VWF. ...

Source: www.ncbi.nlm.nih.gov --- 40 days ago
Related Articles An atypical presentation of Tako-Tsubo Cardiomyopathy. Int J Cardiol. 2008 Aug 29; Authors: Cambronero F, Peñafiel P, Moreno V, Nolte C, Valdés M We present the case of a patient with Tako-Tsubo Cardiomyopathy whose initial diagnosis, based on the location of shoulder and chest pain and electrocardiographic (ECG) changes, suggested that she was suffering from pericarditis. However, 24 h after admission, evolutionary changes of ECG and the echocardiogram performed suggested a Tako-Tsubo Cardiomyopathy. In this context, we review the literature to discuss the clinical presentation and evolutionary ECG changes associated with Tako-Tsubo Cardiomyopathy. PMID: 18757105 [PubMed - as supplied by publisher] ...

Source: www.moreover.com --- 18 days ago
Extract not available. ...

Source: www.ncbi.nlm.nih.gov --- 38 days ago
Related Articles Clozapine-induced Cardiomyopathy presenting as panic attacks. J Psychiatr Pract. 2008 May;14(3):182-5 Authors: Sagar R, Berry N, Sadhu R, Mishra S, Kahn DA PMID: 18520789 [PubMed - indexed for MEDLINE] ...

Source: www.moreover.com --- 23 days ago
Extract not available. ...

Source: www.ncbi.nlm.nih.gov --- 17 days ago
Related Articles [Management of heart diseases in pregnancy: rheumatic and congenital heart disease, myocardial infarction and post partum Cardiomyopathy] Internist (Berl). 2008 Jul;49(7):805-10 Authors: Westhoff-Bleck M, Hilfiker-Kleiner D, Günter HH, Schieffer E, Drexler H Heart disease is present in 0.5-1% of all pregnancies. It is the leading non-obstetric cause of maternal mortality accounting for about 10-15% of all maternal death. Over the last decades the underlying cardiac disease has changed. Also new therapeutic options have been developed. In western industrial countries the incidence of acquired rheumatic heart disease has declined. In contrast, as a result of neonatal corrective or palliative surgery, congenital heart disease has become an increasing and challenging problem. Maternal older age and the increase in women's smoking habits amplify the likelihood of coronary artery disease. Multiple therapeutic options including percutaneous interventions are available and novel therapeutic concepts are emerging i.e. for peripartum Cardiomyopathy. Management of pregnancy, labor and delivery requires accurate diagnosis of the underlying cardiac disorder. Hemodynamic changes physiologically occurring during pregnancy have a different impact depending on the type and severity of cardiac anomalies. Management of these patients requires teamwork of obstetricians, neonatologists, cardiologists, anesthetists and sometimes cardiac sur ...

Source: www.ncbi.nlm.nih.gov --- 17 days ago
Related Articles Severe Left Ventricular Systolic Dysfunction May Reverse with Renal Transplantation: Uremic Cardiomyopathy and Cardiorenal Syndrome. Am J Transplant. 2008 Sep 18; Authors: Zolty R, Hynes PJ, Vittorio TJ Chronic heart failure (CHF) and chronic kidney disease (CKD) are serious medical conditions with significant morbidity and mortality. Emerging evidence indicates that the function of these two organ systems are affected by each other in a complex interplay. Most patients with CKD suffer frequently from cardiac abnormalities including left ventricular hypertrophy (LVH), left ventricular dilatation (LVD), left ventricular (LV) diastolic and/or systolic dysfunction. Although previously thought that LV systolic dysfunction was an absolute contraindication to renal transplantation, several observational studies have shown this not to be true and that transplantation can lead to significant improvement in LV systolic function. Furthermore, correction of the uremic state by renal transplantation leads to improvement of LVD and possibly regression of LVH. In fact, the reduction of LVH postkidney transplantation was shown to be dependent on adequate renal function and hypertension control. Diabetes mellitus does not seem to be a confounding factor in the improvement of uremic Cardiomyopathy with renal transplantation. PMID: 18808406 [PubMed - as supplied by publisher] ...

Source: www.ncbi.nlm.nih.gov --- 33 days ago
Related Articles Likelihood of ventricular arrhythmias due to myocardial fibrosis in hypertrophic Cardiomyopathy as detected by cardiac magnetic resonance imaging. J Am Coll Cardiol. 2008 Sep 9;52(11):969 Authors: Dhoble A, Punnam SR, Abela GS PMID: 18772075 [PubMed - in process] ...

Source: www.ncbi.nlm.nih.gov --- 14 days ago
HHV-6 is frequently identified in archival cardiac tissues from children with idiopathic dilated Cardiomyopathy or congenital heart disease. J Clin Pathol. 2008 Sep 25; Authors: Comar M, D'agaro P, Campello C, Poli A, Breinholt JP, Tobin J, Vatta M Objective: The possible role of Human Herpes Virus-6 in cardiac disorders in childhood was explored in a retrospective study on archival specimens of explanted hearts. METHODS: 16 children (median age at transplantation 11.0 years) with idiopathic dilated Cardiomyopathy (DCM) and 19 children (median age at transplantation 1.0 year) with congenital heart disease (CHD), previously found negative for other cardiotropic viruses such as Enteroviruses, Adenovirus, Parvovirus B19, CMV, and EBV, were tested for HHV-6 by quantitative Real-Time PCR and by genotyping. In addition, HHV-7/8 infection was investigated by qualitative PCR. RESULTS: HHV-6 B variant was detected in 11 out of 35 samples (31.4%) with a mean viral load of 3.15 x102 copies/microg of cellular DNA. When assessed by heart disorder, the prevalence was different in the two groups (i.e. 43.7% in DCM and 21% in CHD) while the mean viral loads were similar. In a logistic multivariate analysis HHV-6 was independently associated with DCM taking CHD as reference and adjusting for age (best estimate: OR 6.94, 95% C.I.: 1.00-49.76, p=0.05). CONCLUSIONS: Although the clinical significance of our finding is unknown, we frequently detected HHV- ...

Source: www.ncbi.nlm.nih.gov --- 36 days ago
Related Articles Reversal of IFN-gamma, oxLDL and prolactin serum levels correlate with clinical improvement in patients with peripartum Cardiomyopathy. Eur J Heart Fail. 2008 Sep 1; Authors: Forster O, Hilfiker-Kleiner D, Ansari AA, Sundstrom JB, Libhaber E, Tshani W, Becker A, Yip A, Klein G, Sliwa K AIM: Peripartum Cardiomyopathy (PPCM) is characterized by acute onset of heart failure of unknown aetiology. We aimed to identify mechanisms involved in initiation and progression of the disease. METHODS AND RESULTS: Serum markers related to cardiac function, apoptosis, oxidative stress, remodelling, inflammation and the nursing hormone prolactin were analyzed in PPCM patients and healthy controls. The kinetics of these markers were compared between patients who improved cardiac function (IMP) and those patients who did not improve (NIMP), over 6 months follow-up. All patients received ACE-inhibitors, beta-blockers and diuretics. Baseline levels of TGF-beta-1 were significantly lower, MMP-9 and VEGF were not different; all other markers were significantly higher in PPCM compared with controls. Only baseline NT-proBNP levels were higher in NIMP compared with IMP. After 6 months, NT-proBNP, oxLDL and IFN-gamma were significantly lower in IMP and the decrease in oxLDL, IFN-gamma and prolactin was significant in IMP but not in NIMP. Significant correlations were observed between the kinetics of NT-proBNP, oxLDL, prolactin and IFN-gamma in PP ...

Source: www.ncbi.nlm.nih.gov --- 22 days ago
Related Articles Extensive venous thrombosis and Cardiomyopathy demonstrated with cardiovascular magnetic resonance. J Cardiovasc Med (Hagerstown). 2008 Oct;9(10):1075-7 Authors: Foley PW, Ratib K, Leyva F We describe a patient who presented with typical symptoms of submassive pulmonary embolism associated with newly diagnosed Cardiomyopathy. Contrast enhanced computed tomography demonstrated extensive venous thrombosis, and late enhancement cardiovascular magnetic resonance imaging was consistent with dilated Cardiomyopathy with midwall fibrosis. We discuss the images and aetiology of the Cardiomyopathy. PMID: 18799976 [PubMed - in process] ...

Source: www.moreover.com --- 18 days ago
Extract not available. ...

Source: www.theheart.org --- 38 days ago
The findings support a strategy of first testing patients for persistent viral load before choosing a treatment strategy. (European Society of Cardiology Congress 2008.) ...

Source: www.healthnews.com --- 40 days ago
read more ...

Source: www.nearlydrferox.blogging4life.com --- 24 days ago
Sometimes it can be difficult to properly learn a condition without having a face and a story to put with it. Feline Hypertropic Cardiomyopathy is the most commonly diagnosed heart condition of cats, with a variable degree of severity. It also occurs in humans, where it is most likely an autosomal dominant genetic trait, and has [...] ...