Carcinogen

Source: www.ncbi.nlm.nih.gov --- 14 days ago
Related Articles ABCG2/BCRP decreases the transfer of a food-born chemical Carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta. Toxicol Appl Pharmacol. 2008 Jul 18; Authors: Myllynen P, Kummu M, Kangas T, Ilves M, Immonen E, Rysä J, Pirilä R, Lastumäki A, Vähäkangas KH We have studied the role of ATP binding cassette (ABC) transporters in fetal exposure to carcinogens using 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) a known substrate for ABC transporters as a model compound. In perfusion of human term placenta, transfer of (14)C-PhIP (2 muM) through the placenta resulted in fetal-to-maternal concentration ratio (FM ratio) of 0.72+/-0.09 at 6 h. The specific ABCG2 inhibitor KO143 increased the transfer of (14)C-PhIP from maternal to fetal circulation (FM ratio 0.90+/-0.08 at 6 h, p<0.05) while the ABCC1/ABCC2 inhibitor probenecid had no effect (FM ratio at 6 h 0.75+/-0.10, p=0.84). There was a negative correlation between the expression of ABCG2 protein in perfused tissue and the FM ratio of (14)C-PhIP (R=-0.81, p<0.01) at the end of the perfusion. The expression of ABCC2 protein did not correlate with FM ratio of PhIP (R: -0.11, p=0.76). In addition, PhIP induced the expression of ABC transporters in BeWo cells at mRNA level. In conclusion, our data indicates that ABCG2 decreases placental transfer of (14)C-PhIP in perfused human placenta. Also, PhIP may modify ABC transporter e ...

Source: www.latimes.com --- 22 days ago
Perfluorooctanoic acid is found in 98% of Americans' blood. The chemical industry says the concerns are based on animal tests and there's no evidence PFOA is harmful to humans. The next time you make some microwave popcorn or cook a frozen pizza, consider this: The packaging of many of these products contains a chemical that the Environmental Protection Agency considers potentially carcinogenic and wants businesses to voluntarily stop using by 2015. ...

Source: www.abc.net.au --- 36 days ago
An interstate academic says blood donated from the Gladstone region needs to be more rigorously tested or temporarily halted by the Red Cross. ...

Source: infoscience.epfl.ch --- 30 days ago
Phosphate and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor gene inactivated in numerous sporadic cancers, including melanomas. To analyze Pten functions in melanocytes, we used the Cre-loxP system to delete Pten specifically in murine pigment-producing cells and generated DctCrePten(flox/flox) mice. Half of DctCrePten(flox/flox) mice died shortly after birth with enlargements of the cerebral cortex and hippocampus. Melanocytes were increased in the dermis of perinatal DctCrePten(flox/flox) mice. When the mutants were subjected to repeated depilations, melanocyte stem cells in the bulge of the hair follicle resisted exhaustion and the mice were protected against hair graying. Although spontaneous melanomas did not form in DctCrePten(flox/flox) mice, large nevi and melanomas developed after Carcinogen exposure. DctCrePten(flox/flox) melanocytes were increased in size and exhibited heightened activation of Akt and extracellular signal-regulated kinases, increased expression of Bcl-2, and decreased expression of p27(Kip1). Our results show that Pten is important for the maintenance of melanocyte stem cells and the suppression of melanomagenesis ...

Source: www.columbiatribune.com --- 40 days ago
The city of Columbia received data this week from a recent round of tests of water in its distribution system, and the news was not good. ...

Source: www.journalstar.com --- 18 days ago
Studies show that this chemical perfluorooctanoic acid, or PFOA is present in 98 percent of Americans blood and... ...

Source: www.sciencealert.com.au --- 18 days ago
An Australian researcher has found a group of microbes that can break down some of the worst cancer-causing substances released by pollution. ...

Source: www.findingdulcinea.com --- 16 days ago
Food manufacturers in California have agreed to phase out acrylamide, a carcinogenic compound found in potato chips and french fries. ...

Source: scienceblogs.com --- 36 days ago
What's a little sodium dichromate, anyway? So it's a known human Carcinogen and can do a lot of other nasty things. No big deal. Not for Iraq war contractor, KBR, anyway. At the time KBR was a subsidiary of Defense Secretary Rumsfeld's Vice President Dick Cheney's former company, Halliburton. So when they were given a lucrative contract to clean up and safeguard Iraqi oilfields after the Bush Mission was Accomplished in 2003, they told the soldiers and workers that the chemical, used as an antirust agent and then strewn all over the oil facilities, was a "mild irritant." Later they admitted this wasn't exactly accurate, so the Army tested blood and urine of over a hundred of the workers for chromium. No problem: Read the rest of this post... | Read the comments on this post... ...

Source: www.scienceblogs.com --- 37 days ago
What's a little sodium dichromate, anyway? So it's a known human Carcinogen and can do a lot of other nasty things. No big deal. Not for Iraq war contractor, KBR, anyway. At the time KBR was a subsidiary of Defense Secretary Rumsfeld's former company, Halliburton. So when they were given a lucrative contract to clean up and safeguard Iraqi oilfields after the Bush Mission was Accomplished in 2003, they told the soldiers and workers that the chemical, used as an antirust agent and then strewn all over the oil facilities, was a "mild irritant." Later they admitted this wasn't exactly accurate, so the Army tested blood and urine of over a hundred of the workers for chromium. No problem: Read the rest of this post... | Read the comments on this post... ...

Source: sefora.org --- 34 days ago
From our friends at Effect Measure What’s a little sodium dichromate, anyway? So it’s a known human Carcinogen and can do a lot of other nasty things. No big deal. Not for Iraq war contractor, KBR, anyway. At the time KBR was a subsidiary of Defense Secretary Rumsfeld’s Vice President Dick Cheney’s former company, Halliburton. So [...] ...

Source: forums.startsampling.com --- 47 days ago
California Attorney General's office press release--chromium dust, with 50 times the legal alert level of chromium, left to blow around the... ...

Source: www.fwicki.com --- 21 days ago
The next time you make some microwave popcorn or cook a frozen pizza, consider this: The packaging of many of these products contains a chemical that the Environmental Protection Agency considers potentially carcinogenic and wants businesses to ... ...

Source: www.thefightagainstcancer.com --- 43 days ago
In large-scale field trials, scientists from North Carolina State University have shown that silencing a specific gene in burley tobacco plants significantly reduces harmful carcinogens in cured tobacco leaves.The finding could lead to tobacco products - especially smokeless products - with reduced amounts of cancer-causing agents.NC State’s Dr. Ralph Dewey, professor of crop science, and [...] ...

Source: www.lime.com --- 15 days ago
  By Stacy Malkan You might expect a shampoo labeled “pure, natural and organic” to be, well, pure, natural and organic. So you may have been shocked — and not a little ticked off — to learn that many of your favorite natural body care products contain a nasty petrochemical linked to cancer. The bad news broke in March at the Natural Products Expo in Anaheim, California, with the release of product tests that found 1,4 dioxane, a probable human Carcinogen, in 46 out of 100... [More at lime.com/health] ...

Source: consumerist.com --- 18 days ago
Four major potato chip makers have agreed to use less of the Carcinogen Acrylamide under a settlement with the California Attorney General's office. Frito-Lay, Heinz, Kettle Foods, and Lance Inc.... [[ This is a content summary only. Visit my website for full links, other content, and more! ]] ...

Source: www.gameinformer.com --- 14 days ago
Activision just released details on a new Guitar Hero III track pack that will available starting August 7. In the pack players can download Flyleaf’s “Tina, the Heartfelt Track,” “AFI’s Carcinogen Crush” and a remix of Marilyn Manson’s “Putting Holes in Happiness” by Nick Zinner from the Yeah Yeah Yeahs. ...

Source: www.dbtechno.com --- 17 days ago
Sacramento (dbTechno) - Public health and safety advocates in California are very happy with a recent settlement reached, as an agreement will reduce the amount of the cancer causing Carcinogen chemical in potato chips. Back in 2005, Attorney General Jerry Brown filed lawsuits against major companies such as Frito-Lay, Lance Inc., Kettle Foods, as well as [...] ...

Source: www.westcoaster.ca --- 13 days ago
By Daina Lawrence The Canadian Press OTTAWA — Health Canada is holding onto a damning report on asbestos on the eve of an international conference at which Canada plans to defend its export of the known Carcinogen, critics say. ...