CYSTIC FIBROSIS

Source: news.yahoo.com --- 21 hours ago
HealthDay - MONDAY, Oct. 13 (HealthDay News) -- Existing guidelines for treating vitamin D deficiency in children with CYSTIC FIBROSIS are too low and put patients at high risk for bone loss and rickets, a new study says. ...

Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles Reproducibility of spirometry during CYSTIC FIBROSIS pulmonary exacerbations. Pediatr Pulmonol. 2008 Oct 7; Authors: Sanders DB, Rosenfeld M, Mayer-Hamblett N, Stamey D, Redding GJ OBJECTIVES:: To compare the within day variation of spirometry between hospital admission, discharge, and outpatient follow up among children with CYSTIC FIBROSIS (CF) hospitalized for a pulmonary exacerbation. HYPOTHESIS:: Within day variation of spirometry will be greater at hospital admission than at hospital discharge or outpatient follow up. METHODS:: We performed a retrospective review of spirometry data for all patients with CF >/=6 years old admitted to our pediatric CF center for a pulmonary exacerbation in 2004 or 2005. For patients who had previously performed spirometry successfully, measurements were used from one admission only during 2004-2005 if the spirometry occurred within 3 days of hospital admission, 3 days of discharge, or at a follow up clinic visit when well. We compared the within day coefficients of variation (CV) for FVC, FEV(1), and FEF(25-75) between time points using the Wilcoxon signed rank-test. We also determined the change in spirometry that is likely to be beyond measurement variability during inpatient treatment of a pulmonary exacerbation. RESULTS:: Spirometry data were available from 40 subjects at admission and follow up and 35 at hospital discharge. There was no significant difference in CV at admissi ...

Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles Expression of CYSTIC FIBROSIS transmembrane conductance regulator in rat ovary. J Huazhong Univ Sci Technolog Med Sci. 2008 Oct;28(5):584-7 Authors: Jin L, Tang R The protein expression of CYSTIC FIBROSIS transmembrane conductance regulator (CFTR), a cAMP-activated Cl(-) channel, in ovarian stimulated premature female rat ovary during a cycle of follicle development and corpus luteum formation was investigated. Animals were injected with 10 U pregnant Mare's serum gonadotropin (PMSG) and subsequently 10 U hCG 48 h later. Time-dependent immunohistochemistry and Western blotting experiments were performed before and 24, 48, 72 h after hCG treatment. The immunohistochemistry revealed that administration of PMSG stimulated the CFTR expression in thecal cell layer and granulosa cell layer of mature follicles 48 h post injection, coincident with the PMSG-induced peak in follicular estradiol. However, the expression of CFTR in the granulose lutein cell layer and thecal lutein cell layer was time-dependently reduced following hCG injection, in accordance with the gradually increased progestogen level during luteum corpus formation. Western blotting analysis demonstrated that rat ovarian tissue expressed the special CFTR band at 170 kD. It is concluded that cAMP-dependent Cl(-) channels are involved in regulation of follicle development and luteum formation. PMID: 18846344 [PubMed - in process] ...

Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles Trampolining as an adjunct to regular physiotherapy in children with CYSTIC FIBROSIS. Ir Med J. 2008 Jun;101(6):188 Authors: Currant J, Mahony M Trampolining has become increasingly popular both in the CYSTIC FIBROSIS and general population. In light of the dangers associated with trampolining we surveyed a sample of our outpatient CF population. We found that over half the group questioned used their trampoline on a daily basis, both as a form of exercise and for some as an alternative to physiotherapy. There were no reports of injury that required medical attention. We plan to encourage continued use of trampolines with the introduction of safety guidelines, reinforcing that trampolining is an adjunct to and not a replacement for regular physiotherapy. PMID: 18700516 [PubMed - indexed for MEDLINE] ...

Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles The impact of incident methicillin resistant Staphylococcus aureus detection on pulmonary function in CYSTIC FIBROSIS. Pediatr Pulmonol. 2008 Oct 7; Authors: Sawicki GS, Rasouliyan L, Pasta DJ, Regelmann WE, Wagener JS, Waltz DA, Ren CL, The incidence of methicillin resistant Staphylococcus aureus (MRSA) infection is increasing in CYSTIC FIBROSIS (CF), but the impact of MRSA detection on clinical outcomes is unclear. Our objective was to determine whether incident detection of MRSA is associated with a change in pulmonary function over time in CF patients. We analyzed data from the Epidemiologic Study of CYSTIC FIBROSIS (ESCF), a prospective observational study of CF patients in North America. Multivariable piecewise linear regression was used to model the impact of incident detection of MRSA on pulmonary function over time, measured by percent predicted forced expiratory volume in one second (FEV(1)% predicted), adjusting for potential confounders. There were 5,090 patients >/=6 years old who were MRSA negative for at least 2 calendar years. Five hundred ninety-three (12%) of these patients acquired MRSA during the years 2001-2003, with detection rates of MRSA during those years rising from 4.4% to 6.9%. MRSA positive patients had a lower FEV(1)% predicted and received more antibiotic and other therapies than patients who remained MRSA negative. After adjusting for antibiotic therapy and other potential confounders, ...

Source: www.medicalnewstoday.com --- 23 hours ago
Kamada (TASE:KMDA), a biopharmaceutical company engaged in the development, manufacturing and marketing of specialty life-saving therapeutics, announced today positive data from its Phase II study evaluating inhaled Alpha-1 Antitrypsin (AAT) delivered via an Investigational eFlow® Nebulizer System (PARI Pharma GmbH), in the treatment of CYSTIC FIBROSIS. ...

Source: wcco.com --- 1 day ago
A different kind of athletic event at the U of M, Liz Collin reports (0:11). ...

Source: www.medpagetoday.com --- 1 day ago
BALTIMORE (MedPage Today) -- For most children with CYSTIC FIBROSIS, Vitamin D deficiency is not corrected with recommended treatment, suggesting guidelines are inadequate, researchers said. ...

Source: www.wafb.com --- 13 hours ago
MONDAY, Oct. 13 (HealthDay News) -- Existing guidelines for treating vitamin D deficiency in children with CYSTIC FIBROSIS are too low and put patients at... ...

Source: www.topix.com --- 18 hours ago
About 8,000 rubber ducks hit the waves to raise money for the CYSTIC FIBROSIS Foundation. ...

Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles Dysfunction of Nrf-2 in CF epithelia leads to excess intracellular H2O2 and inflammatory cytokine production. PLoS ONE. 2008;3(10):e3367 Authors: Chen J, Kinter M, Shank S, Cotton C, Kelley TJ, Ziady AG CYSTIC FIBROSIS is characterized by recurring pulmonary exacerbations that lead to the deterioration of lung function and eventual lung failure. Excessive inflammatory responses by airway epithelia have been linked to the overproduction of the inflammatory cytokine IL-6 and IL-8. The mechanism by which this occurs is not fully understood, but normal IL-1beta mediated activation of the production of these cytokines occurs via H2O2 dependent signaling. Therefore, we speculated that CFTR dysfunction causes alterations in the regulation of steady state H2O2. We found significantly elevated levels of H2O2 in three cultured epithelial cell models of CF, one primary and two immortalized. Increases in H2O2 heavily contributed to the excessive IL-6 and IL-8 production in CF epithelia. Proteomic analysis of three in vitro and two in vivo models revealed a decrease in antioxidant proteins that regulate H2O2 processing, by > or =2 fold in CF vs. matched normal controls. When cells are stimulated, differential expression in CF versus normal is enhanced; corresponding to an increase in H2O2 mediated production of IL-6 and IL-8. The cause of this redox imbalance is a decrease by approximately 70% in CF cells versus normal in the expr ...

Source: www.bignewsnetwork.com --- 18 hours ago
We now have the perfect metaphor for the Middle East's political situation. In Egypt, a little boy with CYSTIC FIBROSIS badly needs a certain medicine. Unfortunately for him, that drug is only produce... ...

Source: speakingofresearch.com --- 1 day ago
CYSTIC FIBROSIS is one of the most commonly inherited diseases, affecting about one in every four thousand children born in the USA, and is caused by mutations in the CYSTIC FIBROSIS transmembrane conductance regulator (CFTR) gene. The CFTR gene produces a channel that allows the transport of chloride ions across membranes in the body, and [...] ...