CIS

Source: www.ncbi.nlm.nih.gov --- 10 days ago
Related Articles Induced ncRNAs allosterically modify RNA-binding proteins in CIS to inhibit transcription. Nature. 2008 Jul 3;454(7200):126-30 Authors: Wang X, Arai S, Song X, Reichart D, Du K, Pascual G, Tempst P, Rosenfeld MG, Glass CK, Kurokawa R With the recent recognition of non-coding RNAs (ncRNAs) flanking many genes, a central issue is to obtain a full understanding of their potential roles in regulated gene transcription programmes, possibly through different mechanisms. Here we show that an RNA-binding protein, TLS (for translocated in liposarcoma), serves as a key transcriptional regulatory sensor of DNA damage signals that, on the basis of its allosteric modulation by RNA, specifically binds to and inhibits CREB-binding protein (CBP) and p300 histone acetyltransferase activities on a repressed gene target, cyclin D1 (CCND1) in human cell lines. Recruitment of TLS to the CCND1 promoter to cause gene-specific repression is directed by single-stranded, low-copy-number ncRNA transcripts tethered to the 5' regulatory regions of CCND1 that are induced in response to DNA damage signals. Our data suggest that signal-induced ncRNAs localized to regulatory regions of transcription units can act cooperatively as selective ligands, recruiting and modulating the activities of distinct classes of RNA-binding co-regulators in response to specific signals, providing an unexpected ncRNA/RNA-binding protein-based strategy to integrate tran ...

Source: www.ncbi.nlm.nih.gov --- 1 day ago
Related Articles A CIS-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nat Genet. 2008 Jul 20; Authors: Rosengren Pielberg G, Golovko A, Sundström E, Curik I, Lennartsson J, Seltenhammer MH, Druml T, Binns M, Fitzsimmons C, Lindgren G, Sandberg K, Baumung R, Vetterlein M, Strömberg S, Grabherr M, Wade C, Lindblad-Toh K, Pontén F, Heldin CH, Sölkner J, Andersson L In horses, graying with age is an autosomal dominant trait associated with a high incidence of melanoma and vitiligo-like depigmentation. Here we show that the Gray phenotype is caused by a 4.6-kb duplication in intron 6 of STX17 (syntaxin-17) that constitutes a CIS-acting regulatory mutation. Both STX17 and the neighboring NR4A3 gene are overexpressed in melanomas from Gray horses. Gray horses carrying a loss-of-function mutation in ASIP (agouti signaling protein) had a higher incidence of melanoma, implying that increased melanocortin-1 receptor signaling promotes melanoma development in Gray horses. The Gray horse provides a notable example of how humans have cherry-picked mutations with favorable phenotypic effects in domestic animals. PMID: 18641652 [PubMed - as supplied by publisher] ...

Source: www.moreover.com --- 21 days ago
Extract not available. ...

Source: www.ncbi.nlm.nih.gov --- 19 days ago
Related Articles DC-SIGN mediates avian H5N1 influenza virus infection in CIS and in trans. Biochem Biophys Res Commun. 2008 Jun 28; Authors: Wang SF, Huang JC, Lee YM, Liu SJ, Chan YJ, Chau YP, Chong P, Chen YM DC-SIGN, a C-type lectin receptor expressed in dendritic cells (DCs), has been identified as a receptor for human immunodeficiency virus type 1, hepatitis C virus, Ebola virus, cytomegalovirus, dengue virus, and the SARS coronavirus. We used H5N1 pseudotyped and reverse-genetics (RG) virus particles to study their ability to bind with DC-SIGN. Electronic microscopy and functional assay results indicate that pseudotyped viruses containing both HA and NA proteins express hemagglutination and are capable of infecting cells expressing alpha-2,3-linked sialic acid receptors. Results from a capture assay show that DC-SIGN-expressing cells (including B-THP-1/DC-SIGN and T-THP-1/DC-SIGN) and peripheral blood dendritic cells are capable of transferring H5N1 pseudotyped and RG virus particles to target cells; this action can be blocked by anti-DC-SIGN monoclonal antibodies. In summary, (a) DC-SIGN acts as a capture or attachment molecule for avian H5N1 virus, and (b) DC-SIGN mediates infections in CIS and in trans. PMID: 18593570 [PubMed - as supplied by publisher] ...

Source: www.moreover.com --- 22 days ago
/PanARMENIAN.Net/ Armenian delegation led by Defense Minister Seyran Ohanyan departed for Bishkek, Kyrgyzstan, to attend a regular meeting of CIS Defense Ministers due on July 2. As the Minister's spokesman, col. Seyran Shahsuvaryan told PanARMENIAN.Net, ...

Source: isohunt.com --- 17 days ago
Bit Torrent details: Category: TV Original site: http://www.bittorrent.am/ Size: 8160.45 MB, in 635 files Seeds: 1 - Leechers: 0 - Downloads: 0 Description: Navy.CIS.Staffel.02.Komplett ...

Source: newsroom.cisco.com --- 21 days ago
SAN JOSE, Calif., July 2, 2008 - Cisco today furthered its strategy of investment in the Russian technology industry with the announcement of an anchor investment in a venture capital fund that will focus on Russia and the Commonwealth of Independent States (CIS). In collaboration with Almaz Capital Partners, Cisco has made the anchor investment in Almaz Capital Russia Fund I, L.P. (to be informally called 'Almaz Capital / Cisco Fund I'), which has initially closed at $60 million. ... ...

Source: www.marketwire.com --- 22 days ago
SAN JOSE, CA (MARKET WIRE) Cisco (NASDAQ: CSCO) today furthered its strategy of investment in the Russian technology industry with the announcement of an anchor investment in a venture capital fund that will focus on Russia and the Commonwealth of Independent States (CIS). In collaboration with Almaz Capital Partners, Cisco has made the anchor investment in Almaz Capital Russia Fund I, L.P. (to be informally called 'Almaz Capital / Cisco Fund I'), which has initially closed at $60 million. ...

Source: enhancement.tamu.edu --- 4 days ago
Scheduled for Fri, 18 Jul 2008 09:00 CDT through Tue, 22 Jul 2008 09:00 CDT. The CIS Machine Room is adding one cooling unit and relocating another unit with the room to enhance the air flow and lower the room temperature. The new unit has been added and we are now in the process of relocating the second unit. Source: keystone 236389 [Enhancement] ...

Source: www.moreover.com --- 15 days ago
Travel Weekly Web Jul 8 2008 9:36PM GMT ...

Source: clientportal.ibb.ubs.com --- 21 days ago
This document is related to the following: Regions Global Russia EMEA Emerging UBSW EMEA Emerging Markets Sectors Global Gas Utilities Global Oil Companies, Major Global Real Estate Russian Gas Utilities Russian Oil Companies, Major Russian Real Estate Russian Wireless Communications Russian Fixed-Line Communications EMEA Emerging Wireless Communications EMEA Emerging Fixed-Line Communications EMEA Emerging Gas Utilities EMEA Emerging Oil Companies, Major EMEA Emerging Real Estate Global Wireless Communications Global Fixed-Line Communications EMEA Emerging Energy EMEA Emerging Financial EMEA Emerging Telecommunications EMEA Emerging Utilities Global Energy Global Financial Global Telecommunications Global Utilities Russian Energy Russian Financial Russian Telecommunications Russian Utilities EMEA Emerging Financial Services Global Financial Services Russian Financial Services Global Emerging Wireless Communications Global Emerging Energy Global Emerging Financial Global Emerging Fixed-Line Communications Global Emerging Financial Services Global Emerging Gas Utilities Global Emerging Oil Companies, Major Global Emerging Real Estate Global Emerging Telecommunications Global Emerging Utilities Companies RTKM.RTS Rostelecom GAZPq.L Gazprom VIP.N VimpelCom KUBN.RTS South Telecom TNBPI.RTS TNK-BP Holding OPIN.RTS Open Investments Subjects Market Strategy / Comment Morning Note ...

Source: clientportal.ibb.ubs.com --- 13 hours ago
This document is related to the following: Regions Global Russia EMEA Emerging UBSW EMEA Emerging Markets Companies IRGZ.RTS Irkutskenergo LKOH.RTS Lukoil GAZPq.L Gazprom SIBN.RTS Gazprom Neft CHMFq.L Severstal TRNF_p.RTS Transneft VTBRq.L VTB NLMKq.L Novolipetsk FESH.RTS Fesco APTK.RTS Pharmacy Chain 36.6 MTL.N Mechel PJPq.L X5 Retail Group PLZL.MM Polyus Gold ROSNq.L Rosneft OGKF.RTS OGK-6 MLD.L Mirland AFIDLq.L AFI Development PKGPq.L PIK ALLBq.L Alliance Bank Subjects Market Strategy / Comment Morning Note ...

Source: clientportal.ibb.ubs.com --- 20 days ago
This document is related to the following: Regions Global Russia EMEA Emerging UBSW EMEA Emerging Markets Companies IRGZ.RTS Irkutskenergo GAZPq.L Gazprom SIBN.RTS Gazprom Neft CHMF.RTS Severstal TRNF_p.RTS Transneft VTBRq.L VTB ESPK.RTS Far East Telecom NLMKq.L Novolipetsk APTK.RTS Pharmacy Chain 36.6 MTL.N Mechel PJPq.L X5 Retail Group PLZL.RTS Polyus Gold ROSNq.L Rosneft OGKF.RTS OGK-6 MLD.L Mirland AFIDLq.L AFI Development PKGPq.L PIK ALLBq.L Alliance Bank Subjects Market Strategy / Comment Morning Note ...

Source: www.utk.edu --- 7 days ago
In 2007 U.S. Army veteran Jerry Bechel decided to start his own business, Veterans National Contracting LLC. He was uncertain how to navigate the processes and paperwork, so he asked counselors with the Procurement Technical Assistance Center at the UT Center for Industrial Services for help. ...

Source: clientportal.ibb.ubs.com --- 5 days ago
This document is related to the following: Regions Global Russia EMEA Emerging UBSW EMEA Emerging Markets Companies IRGZ.RTS Irkutskenergo GMKN.RTS Norilsk Nickel GAZPq.L Gazprom VIP.N VimpelCom SIBN.RTS Gazprom Neft CHMFq.L Severstal TRNF_p.RTS Transneft VTBRq.L VTB NLMKq.L Novolipetsk APTK.RTS Pharmacy Chain 36.6 MTL.N Mechel HK1q.L Evraz TNBPI.RTS TNK-BP Holding PJPq.L X5 Retail Group PLZL.RTS Polyus Gold CMSTq.L Comstar ROSNq.L Rosneft OGKF.RTS OGK-6 TGKF.RTS TGK-6 MLD.L Mirland AFIDLq.L AFI Development PKGPq.L PIK ALLBq.L Alliance Bank Subjects Market Strategy / Comment Morning Note ...

Source: www.moreover.com --- 21 days ago
Nature Jul 2 2008 7:29PM GMT ...

Source: pubs.acs.org --- 17 days ago
Gerrit J. Poelarends, Hector Serrano, Maria D. Person, William H. Johnson Jr., and Christian P. Whitman Web Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/bi8007388 ...

Source: clientportal.ibb.ubs.com --- 17 days ago
This document is related to the following: Regions Global Russia EMEA Emerging UBSW EMEA Emerging Markets Companies IRGZ.RTS Irkutskenergo GMKN.RTS Norilsk Nickel GAZPq.L Gazprom SIBN.RTS Gazprom Neft CHMF.RTS Severstal TRNF_p.RTS Transneft VTBRq.L VTB NLMKq.L Novolipetsk APTK.RTS Pharmacy Chain 36.6 MTL.N Mechel SSAq.L Sistema PJPq.L X5 Retail Group PLZL.RTS Polyus Gold ROSNq.L Rosneft OGKF.RTS OGK-6 PMTLq.L Polymetal MLD.L Mirland AFIDLq.L AFI Development VRPH.RTS Veropharm PKGPq.L PIK ALLBq.L Alliance Bank Subjects Market Strategy / Comment Morning Note ...

Source: clientportal.ibb.ubs.com --- 8 days ago
This document is related to the following: Regions Global Russia EMEA Emerging UBSW EMEA Emerging Markets Subjects Market Strategy / Comment Morning Note ...