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Source: www.ncbi.nlm.nih.gov --- 35 days ago
Related Articles Proline Affects Brain Function in 22q11DS Children with the Low Activity COMT(158) Allele. Neuropsychopharmacology. 2008 Sep 3; Authors: Vorstman JA, Turetsky BI, Sijmens-Morcus ME, de Sain MG, Dorland B, Sprong M, Rappaport EF, Beemer FA, Emanuel BS, Kahn RS, van Engeland H, Kemner C The association between the 22q11.2 deletion syndrome (22q11DS) and psychiatric disorders, particularly psychosis, suggests a causal relationship between 22q11DS genes and abnormal Brain function. The genes catechol-O-methyl-transferase (COMT) and proline dehydrogenase both reside within the commonly deleted region of 22q11.2. COMT Activity and proline levels may therefore be altered in 22q11DS individuals. Associations of both COMT(158) genotype and elevated serum proline levels with abnormal Brain function have been reported. Fifty-six 22q11DS children and 75 healthy controls were assessed on physiological measures of Brain function, including prepulse inhibition (PPI) of startle, P50 auditory sensory gating and smooth pursuit eye movements (SPEM). COMT(158) genotype and plasma proline levels were determined in the 22q11DS children. We hypothesized an interaction between the COMT(158) genotype and proline, predicting the strongest negative effect of high proline on Brain function to occur in 22q11DS children who are carriers of the COMT(met) allele. Of the three physiological measures, only SPEM and PPI were abnormal in the patient samp ... Source: www.ncbi.nlm.nih.gov --- 34 days ago
Related Articles [Brain electrical Activity and emotional state of pregnant women after treatment of infertility] Zh Nevrol Psikhiatr Im S S Korsakova. 2007;107(6):68-70 Authors: Kul'chimbaeva SM, Mamedalieva NM, Kamenova SU, Kuzhybaeva KK PMID: 18683349 [PubMed - indexed for MEDLINE] ... Source: www.ncbi.nlm.nih.gov --- 21 days ago
Related Articles A critical overview of the influence of inflammation and infection on P-glycoprotein expression and Activity in the Brain. Expert Opin Drug Metab Toxicol. 2008 Oct;4(10):1245-1264 Authors: Roberts DJ, Goralski KB Background: P-glycoprotein is a blood-Brain barrier efflux transporter that limits drug accumulation in the Brain. Objective: To review recent in vivo and in vitro investigations that examined the influence of inflammation, infection and related clinical neuroinflammatory disorders on P-glycoprotein expression and Activity in the Brain. Methods: Critical overview of English-language studies. Results/conclusions: Inflammation and infection produce dynamic changes in P-glycoprotein expression and Activity in the blood-Brain barrier. In vitro, blood-Brain barrier P-glycoprotein Activity is downregulated after short-term exposure to inflammatory mediators whereas its Activity is upregulated following more prolonged exposure. In vivo studies in both humans and animals have linked CNS inflammation, peripheral inflammation and related clinical neuroinflammatory disorders with alterations in the expression and Activity of blood-Brain barrier P-glycoprotein. The direction and degree of change in P-glycoprotein Activity depends on the in vivo or in vitro model examined, the cell type examined (e.g., endothelial or glial), the inflammatory mediator utilized, the anatomic site in which the inflammatory response was first ... Source: www.ncbi.nlm.nih.gov --- 13 days ago
The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase Activity, amyloid beta and cholesterol synthesis in rat Brain. Steroids. 2008 Sep 5; Authors: Lubica C, Radomir H, Stanislav M, Norbert C, Helena Z, Daniel J, Alena T, Eva B, Vladimir P OBJECTIVE: There is evidence to suppose that cholesterol-lowering medicine might confer protection against dementia, probably via modulation of cholesterol synthesis in the Brain. The aim of the present study was to investigate the potential influence of statins and cholesterol diet on selected parameters relevant to Alzheimer's disease pathophysiology. METHODS: For 15 days, rats were orally administered simvastatin (10 or 20mg/kg b.wt.), atorvastatin (10 or 20mg/kg b.wt.), or aqua (control group); and one group was fed high-cholesterol (2%) diet. At the end of experiments Brain (and plasma) cholesterol, lathosterol, hydroxymethylglutaryl-coenzyme A reductase protein, acetylcholinesterase Activity, amyloid beta (40 and 42) and cholesterol synthesis rate (using the incorporation of deuterium from deuterated water) were determined and statistically compared to those of aqua. RESULTS: Both statins were able to lower cholesterol in the plasma, but none elicited an effect on total Brain cholesterol. Significant reductions of Brain lathosterol and cholesterol synthesis rate were observed after simvastatin and atorvastatin treatment. Acetylcholinesterase Activity, amy ... Source: www.ncbi.nlm.nih.gov --- 23 days ago
Related Articles Large-scale Brain networks account for sustained and transient Activity during target detection. Neuroimage. 2008 Aug 28; Authors: Mantini D, Corbetta M, Perrucci MG, Romani GL, Del Gratta C Target detection paradigms have been widely applied in the study of human cognitive functions, particularly those associated with arousal, attention, stimulus processing and memory. In EEG recordings, the detection of task-relevant stimuli elicits the P300 component, a transient response with latency around 300 ms. The P300 response has been shown to be affected by the amount of mental effort and learning, as well as habituation. Furthermore, trial-by-trial variability of the P300 component has been associated with inter-stimulus interval, target-to-target interval or target probability; however, understanding the mechanisms underlying this variability is still an open question. In order to investigate whether it could be related to the distinct cortical networks in which coherent intrinsic Activity is organized, and to understand the contribution of those networks to target detection processes, we carried out a simultaneous EEG-fMRI study, collecting data from 13 healthy subjects during a visual oddball task. We identified five large-scale networks, that largely overlap with the dorsal attention, the ventral attention, the core, the visual and the sensory-motor networks. Since the P300 component has been consistently associated wi ... Source: www.ncbi.nlm.nih.gov --- 26 days ago
Related Articles Dietary supplementation with N-acetylcysteine, alpha-tocopherol and alpha-lipoic acid prevents age related decline in Na(+),K (+)-ATPase Activity and associated peroxidative damage in rat Brain synaptosomes. Biogerontology. 2008 Sep 12; Authors: Bagh MB, Maiti AK, Roy A, Chakrabarti S This study has shown that in aged rat Brain (22-24 months) crude synaptosomes in comparison to that in young animals (4-6 months), a striking decrease in the Activity of Na(+),K(+)-ATPase occurs along with decreased K (m) and V (max) but without any change in enzyme content as seen by immunoblotting. This is associated with an accumulation of peroxidative damage products in aged Brain. When rats are given antioxidant supplementation in the diet with a combination of N-acetylcysteine, alpha-tocopherol and alpha-lipoic acid daily from 18 months onwards and sacrificed at 22-24 months for experimentation, the age associated decrease of Na(+),K(+)-ATPase Activity, alterations of its kinetic parameters and accumulation of peroxidative damage products in Brain synaptosomes are prevented nearly completely. Because of the critical importance of Na(+),K(+)-ATPase in neuronal functions, the results of this study may be of potential implications in controlling age-related functional deficits of the Brain. PMID: 18787974 [PubMed - as supplied by publisher] ...
Source: www.associatedcontent.com --- 19 days ago
Fall is almost here Learn what fall Activity ideas and thought provoking questions are ideal to use with those who have Alzheimers disease and other dementias Find out why it is so important to stimulate the minds of these folks ... Source: proquest.umi.com --- 36 days ago
Richard B Silberstein, Geoffrey E Nield. International Journal of Advertising. Eastbourne: 2008. Vol. 27, Iss. 3; p. 359 Available Formats: Abstract ... Source: www.medicalnewstoday.com --- 35 days ago
Ever seen or heard something that wasn't there? For most of us such experiences - termed hallucinations - are a normal, fleeting, Brain glitch; yet for a few they are persistent, distressing and associated with a range of psychiatric, neurological and eye conditions. In the September Issue of Cortex Dominic H. ... Source: www.medicalnewstoday.com --- 9 days ago
A study in the Oct. 1 issue of the journal Sleep shows that the successful manipulation of sensorimotor rhythm (SMR) amplitude by instrumental SMR conditioning (ISC) improved sleep quality as well as declarative learning. ISC might thus be considered a promising non-pharmacological treatment for primary insomnia. This study allowed participants to "shape their own Brain Activity" by directly modifying certain electroencephalographic (EEG) activities. ... Source: www.medpagetoday.com --- 9 days ago
SALZBURG, Austria (MedPage Today) -- Sleep as well as memory may be enhanced by training specific Brain rhythms, researchers here found. ...
Source: sports.aol.com --- 21 days ago
by Michael David Smith Filed under: Boxing Gossip Boxer Oscar Diaz is conscious and stable two months after suffering life-threatening Brain injuries in the ring, but he still has a long way to go and will probably never make a full recovery. Dr. David Jimenez said tests show good Brain Activity , but there's still a long way to go before he can make any type of prediction of the extent to which Diaz will recover -- and it's not realistic to think he'll be the same as he was before the injuries: "I don't see him going back to the way he was before" the accident, Jimenez said. "It's going to be a long process, one step at a time." Jimenez said doctors will surgically reinsert the section of skull that was removed during emergency surgery on the night of the fight. Diaz will then spend several weeks in intermediate care and several more weeks in rehabilitation. But even if Diaz is never the same again, the mere fact that he's alive is a tribute to the first-rate medical care he got in the hours after the fight. Diaz suffered the injuries in a TKO loss to Delvin Rodriguez. The fight was shown live on ESPN2. Permalink | Email this | Linking Blogs | Comments ... Source: www.medgadget.com --- 25 days ago
Mayo Clinic researchers have developed an implantable Brain sensor to measure the concentration changes of neurotransmitters like dopamine, serotonin, and glutamate in patients undergoing deep Brain stimulation (DBS) therapy. This new system, called a wireless instantaneous neurotransmitter concentration sensor (WINCS), will be surgically implanted in the Brain to provide real-time measurements of chemical levels (e.g., dopamine, serotonin, and glutamate). The hope is that these measurements can help direct neurosurgeons in the optimal placement of the stimulating electrode during DBS, thereby improving outcomes for patients. DBS is a neurosurgical treatment that stimulates the Brain with mild electrical signals that reorganize the Brain's electrical and chemical Activity. DBS causes improvements in symptoms in a number of conditions affecting the Brain, including Parkinson's disease, tremor, epilepsy, depression and chronic pain. "Potential future implications for this technology are immense," says Kendall Lee, M.D., Ph.D., a Mayo Clinic neurosurgeon and director of the Mayo Clinic Neural Engineering laboratory. "WINCS may be part of a smart deep Brain stimulation device that is able to regulate neurotransmitter systems in the Brain to better treat diseases such as Parkinson's disease, depression, chronic pain and others." Here's video of Kevin Bennet , chair of Mayo Clinic Division of Engineering, giving an overview of the techn ... Source: psychcentral.com --- 14 days ago
New Brain imaging studies have improved the understanding of how the human Brain regulates emotions, report scientists from Columbia University. The research, published by Cell Press in the journal Neuron, identifies Brain pathways that underlie reinterpretation of aversive images in ways that reduce or enhance their negative emotional intensity. “If our emotions are [...] ... Source: life.wchpeng.com --- 30 days ago
It has been ages since my last visit to a real casino!! To be frank, I don’t really like the real casino here which is located up to the hill. I been hearing a lot of bad story as well as many accident happened along the journey up to the hill, so I would prefer [...] ... Source: www.cwinfonet.org --- 29 days ago
Experts agree that art has a positive impact and toddlers. Children who are exposed to arts such as music and painting develop pattern processing, analysis skills, and creativity much quicker than those who are not exposed to arts. An easy way for your child to experience art in a fun and active way is to [...] ... Source: www.nuclearmed.com --- 19 days ago
Page: 681 DOI: 10.1097/RLU.0b013e318184b435 Authors: Britz-Cunningham, Scott H. MD, PhD; Millstine, John W. MD; Gerbaudo, Victor H. PhD ... Source: www.uams.edu --- 16 hours ago
Researcher Receives Grant to Study Brain Activity of Addicts ... Find more results for Brain Activity on RSSMicro.com |
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Is reward circuitry “retuned” in old age? ...
Because conventional lie detector test (the polygraph) is not really a hundred percent reliable, alternative lie detectors have been developed over time. EEGs and fMRIs can measure Brain Activity and seem to have good potential. However, EEGs provide low resolution images and fMRIs are extremely expensive. Scott Bunce from the Drexel University's College of Medicine in Philadelphia turned to infrared rays and thought it a better alternative to the polygraph test. Bunce's model is to emit near-infrared light through the skull into the Brain using a special headband designed just for the purpose. The aim is to measure Brain Activity by monitoring how much light is reflected back. According to NewScientist , the light than bounces back depends upon the blood oxygen levels, which are indicative of Brain Activity. Unfortunately, it's not even known yet whether Brain Activity could be a measure of deception, so this gadget might not even be of use at all, if ever. Check out the infrared lie detector headband patent application ...