Aspirin

Source: news.bbc.co.uk --- 14 days ago
Most men over 48 and women over 57 should take a daily Aspirin pill to reduce the risk of heart attacks, UK researchers say. ...

Source: www.ncbi.nlm.nih.gov --- 5 days ago
Related Articles Selenium status in patients with Aspirin-induced asthma. Ann Clin Biochem. 2008 Sep;45(Pt 5):508-12 Authors: Hassan AM BACKGROUND: Platelets are involved in the pathogenesis of Aspirin-induced asthma (AIA). AIA patients suffer from an active disease despite avoidance of Aspirin, and it has been suggested that administration of Aspirin to these patients increases the generation of immediate oxygen products of arachidonic acid, 12-hydroperoxyeicosatetraenoic acid (12-HPETE), in their platelets. 12-HPETE further activates the 5-lipoxygenase of leukotriene B4-producing inflammatory macrophages precipitating an acute asthmatic attack. Glutathione peroxidase (GPX) has the antioxidant capacity to reduce 12-HPETE, and thus modulate the arachidonic acid metabolic cascade. There is evidence that selenium (Se) nutrition can influence asthma but Se status in AIA patients has not received much attention. METHODS: We measured Se concentrations and GPX activities in platelets and plasma from 13 patients with AIA. Age- and sex-matched healthy individuals served as the control group. RESULTS: Patients with AIA had significantly higher median platelet Se concentration (102 ng/mg platelet protein) when compared with controls (49 ng/mg platelet protein, P = 0.003). Plasma Se concentrations in patients with AIA and controls were not significantly different (P = 0.59). Median platelet GPX activity was significantly higher in patients with A ...

Source: www.ncbi.nlm.nih.gov --- 4 days ago
Related Articles Increased levels of cysteinyl-leukotrienes in saliva, induced sputum, urine and blood from Aspirin-intolerant asthmatics. Thorax. 2008 Aug 29; Authors: Gaber F, Daham K, Higashi A, Higashi N, Gulich A, Delin I, James A, Skedinger M, Gyllfors P, Nord M, Dahlén SE, Kumlin M, Dahlén B BACKGROUND: Diagnosis of Aspirin-intolerant asthma requires Aspirin provocation in specialist clinics. Urinary leukotriene E4 is elevated in Aspirin-intolerant asthma. OBJECTIVE: New biomarkers of Aspirin-intolerance were investigated by comparing basal levels of cysteinyl-leukotrienes and leukotriene B4 in saliva, sputum, and ex vivo stimulated blood in subjects with Aspirin-intolerant and Aspirin-tolerant asthma. The effects of Aspirin- and allergen-induced bronchoconstriction on leukotriene levels in saliva and ex vivo stimulated blood were also compared with the effects of the provocations on urinary mediators. METHODS: Induced sputum, saliva, urine and blood were obtained at baseline in 21 subjects with asthma. At a separate visit, eleven subjects showed a positive response to lysine-Aspirin inhalation whereas ten were Aspirin tolerant. Saliva, blood and urine were also collected on the provocation day. Analyses of cysteinyl-leukotrienes and leukotriene B4 and the prostaglandin D2 metabolite 9alpha,11beta-prostaglandin F2 were performed and the fraction of exhaled nitric oxide was measured. RESULTS: Subjects with Aspirin-intolerant asthm ...

Source: www.ncbi.nlm.nih.gov --- 4 days ago
Related Articles Non-Compliance is the predominant cause of Aspirin resistance in chronic coronary arterial disease patients. J Transl Med. 2008 Aug 29;6(1):46 Authors: Schwartz KA, Schwartz DE, Barber K, Reeves M, De Franco AC ABSTRACT: BACKGROUND: Our previous publication showed that 9% of patients with a history of myocardial infarction MI. could be labeled as Aspirin resistant; all of these patients were Aspirin resistant because of non-compliance. This report compares the relative frequency of Aspirin resistance between known compliant and non-compliance subjects to demonstrate that non-compliance is the predominant cause of Aspirin resistance. METHODS: The difference in the slopes of the platelet prostaglandin agonist (PPA) light aggregation curves off Aspirin and 2 hours after observed Aspirin ingestion was defined as net Aspirin inhibition. RESULTS: After supposedly refraining from Aspirin for 7 days, 46 subjects were judged non-compliant with the protocol. Of the remaining 184 compliant subjects 39 were normals and 145 had a past history of MI. In known compliant subjects there was no difference in net Aspirin inhibition between normal and MI subjects. Net Aspirin inhibition in known compliant patients was statistically normally distributed. Only 3% of compliant subjects (2 normals and 5 MI) had a net Aspirin inhibitory response of less than one standard deviation which could qualify as a conservative designation of Aspirin re ...

Source: news.telegraph.co.uk --- 14 days ago
An Aspirin a day can prevent heart attacks and strokes says study. ...

Source: www.dailymail.co.uk --- 13 days ago
Middle aged people should take a daily Aspirin to prevent heart attacks and strokes, doctors say. ...

Source: www.dailymail.co.uk --- 14 days ago
Middle aged people should take a daily Aspirin to prevent heart attacks and strokes, doctors say. ...

Source: www.timesonline.co.uk --- 13 days ago
The middle-aged should take an Aspirin daily to help to prevent heart attacks, research has suggested. ...

Source: www.businesswire.com --- 5 days ago
PHILADELPHIA--(BUSINESS WIRE)--Der Thrombozytenaggregationshemmer AGGRASTAT® (Tirofiban-HCL), ein Glycoprotein IIb/IIIa-Hemmer, kann das ...

Source: www.911tabs.com --- 10 days ago
Aspirin chords by Seka Aleksic from Ultimate Guitar Archive website. Direct URL to the tab: click ...

Source: www.marketwire.com --- 3 days ago
WINNIPEG, MANITOBA (MARKET WIRE) Medicure Inc. (TSX: MPH), a cardiovascular focused, biopharmaceutical company, today announced that new data presented at the annual European Society of Cardiology Congress in Munich, Germany showed AGGRASTAT(R) (tirofiban HCL) significantly lowers the incidence of heart attack after elective coronary angioplasty in coronary artery disease patients who have shown poor response to standard oral antiplatelet agents, Aspirin and clopidogrel. The data comes from a double-blinded study of AGGRASTAT(R) entitled the 3T/2R Study (Tailoring Treatment with Tirofiban in patients showing Resistance to ...

Source: www.medscape.com --- 3 days ago
In this third factorial analysis of the PROFESS trial, researchers found no sign of neuroprotection from a recurrent stroke with dipyridamole, Aspirin, or telmisarta Medscape Medical News ...

Source: www.moreover.com --- 5 days ago
MedWire News Sep 1 2008 4:49PM GMT ...

Source: www.moreover.com --- 13 days ago
MedWire News Aug 25 2008 1:37AM GMT ...

Source: talk.sheknows.com --- 15 days ago
Forum: TTC - Cycle Buddies Posted By: ReBail Post Time: 08-23-2008 at 10:14 AM ...

Source: www.king5.com --- 17 hours ago
Doctors have turned back the clock more than 100 years to rediscover a cousin of Aspirin that could help the more than 15 million Americans with Type 2 diabetes. ...

Source: www.theheart.org --- 3 days ago
In this third factorial analysis of the PROFESS trial, researchers found no sign of neuroprotection from a recurrent stroke with dipyridamole, Aspirin, or telmisartan. (Diener HC et al. Lancet Neurol ; published online before print August 29, 2008.) ...

Source: www.theheart.org --- 4 days ago
A new study in low-risk, elective-PCI patients who were also nonresponsive to Aspirin and/or clopidogrel shows that adding tirofiban during PCI can cut MI rates by more than 40%, as compared with patients given a placebo infusion. (European Society of Cardiology Congress 2008.) ...

Source: community.wddty.com --- 10 days ago
Aspirin seems to have reclaimed the mantle of 'wonder drug' over the last couple of days with new research that recommends all healthy men and women who are 50 years and older should take one a day to prevent heart attack and stroke. It's not the first time that Aspirin has been promoted as the ultimate prophylactic that needs to be part of everyone's daily health regime.  The abilities of the painkiller to ward off heart attack and stroke were first noted in 1953, and its standing as the greatest of all drugs reached its zenith in 2005 when a major study confirmed its effectiveness. Indeed, we all view it as our health-giving friend that we don't even bother mentioning it as one of the drugs we take.  Researchers found this out when they interviewed patients being treated in hospital for gastro-intestinal problems.  One in five was taking the drug, but hadn't told medical staff.  This also suggests that the true extent of adverse reactions to the drug, and especially stomach bleeding and other gastic problems, is far higher than official figures tell us. But there's something else to consider, especially if you're 75 years or older.  It appears that, far from protecting the elderly against stroke, Aspirin is one of the major cause of cerebral haemorrhage, or stroke.  Researchers from Oxford University made the discovery when they compared numbers of stroke victims between 1981 and 1985 and again between 2002 and 2006.  While the over ...