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Source: panicdisorder.about.com --- 3 days ago
Tricyclic Antidepressants are an older class of Antidepressants sometimes prescribed to treat panic disorder. Although these Antidepressants often have more side effects than the newer classes of Antidepressants, some individuals find better relief from panic disorder with these medications. Here are the basics on tricyclic Antidepressants. ... Source: pediatrics.about.com --- 4 days ago
Does taking Antidepressants, such as Prozac, Zoloft, Celexa, Paxil CR, Effexor, Remeron, and Serzone, increase a child's risk of committing suicide? The FDA is investigating this important topic. ... Source: depression.about.com --- 32 days ago Source: mentalhealth.about.com --- 30 days ago
SSRIs are popular Antidepressants, but they can have side effects. Find out more about such as Celexa (citalopram), Luvox (fluvoxamine), Paxil (paroxetine), Prozac (fluoxetine), and Zoloft (sertraline). ... Source: mentalhealth.about.com --- 16 days ago
The U.S.Food and Drug Administration has issued a public health advisory about potential risks of taking certain migraine medications - triptans - together with certain Antidepressants. The advisory states, "A... ... Source: www.ncbi.nlm.nih.gov --- 11 days ago
Related Articles Effect of some Antidepressants on the low corticosterone concentration-induced gene transcription in LMCAT fibroblast cells. J Physiol Pharmacol. 2008 Mar;59(1):153-62 Authors: Otczyk M, Mulik K, Budziszewska B, Jaworska-Feil L, Basta-Kaim A, Kubera M, Jagła G, Nowak W, Lasoń W The aim of the present study was to investigate effects of some classical and new Antidepressants on functional activity of the glucocorticoid receceptor (GR) induced by low corticosterone concentration in mouse fibroblast cells stably transfected with mouse mammary tumor virus-chloramphenicol acetyltransferase plasmid (LMCAT cells). We found that the transcriptional activity of GR stimulated by 50 nM corticosterone was strongly attenuated by imipramine, desipramine, fluoxetine and tianeptine in a concentration-dependent way, whereas reboxetine had only a weak effect and venlafaxine was inactive. Further study revealed that the inhibitor of c-Jun N-terminal kinase - mitogen-activated protein kinase (JNK-MAPK), SP600125 (0.1 microM), reversed the imipramine-induced suppression of GR function, whereas the inhibitor of extracellular signal-regulated kinase (ERK)-MAPK, PD 98059 (15 microM), potentiated the antidepressant action. No effect of selective inhibitors of p38-MAPK, phosphatidylinositol 3-kinase (PI3-K)/Akt, and glycogen synthase kinase (GSK-3) on the imipramine-induced inhibition of GR function was detected. These data indicate that the fu ... Source: www.ncbi.nlm.nih.gov --- 15 days ago
Related Articles [Rationalizing the prescription of Antidepressants] Rev Prat. 2008 Feb 29;58(4):395-402 Authors: Boulenger JP, Attal J The prescription of antidepressant drugs should only concern depressed patients fulfilling diagnostic criteria for a major depressive episode. This prescription should remain as simple as possible and the association of other psychotropic drugs should not be systematic. Optimal doses should be reached rapidly but the therapeutic efficacy will only become obvious after 2-4 weeks and complete after 6-8 weeks. As most Antidepressants display a similar therapeutic efficacy, the choice will depend on tolerability, patient characteristics and the result of previous therapeutic attempts. Prescribing an antidepressant requires a thorough supervision and repeated visits during the first weeks of treatment. The recommended duration of treatment for a depressive episode is six months and the medication should he tapered off progressively in order to avoid withdrawal symptoms. PMID: 18506979 [PubMed - indexed for MEDLINE] ... Source: www.ncbi.nlm.nih.gov --- 4 days ago
Related Articles Efficacy of second generation Antidepressants in late-life depression: a meta-analysis of the evidence. Am J Geriatr Psychiatry. 2008 Jul;16(7):558-67 Authors: Nelson JC, Delucchi K, Schneider LS OBJECTIVE: Second-generation Antidepressants are commonly used to treat major depression in late-life. This systematic review and meta-analysis was undertaken to assess the evidence for efficacy of second-generation Antidepressants in late-life major depression. METHODS: The Cochrane Library (2006 [3]), MEDLINE (1966 to August 2006), and meeting presentations were searched for trials of second-generation Antidepressants (nontricyclics) marketed in the United States. Published and unpublished placebo-controlled randomized clinical trials in outpatients 60 years and older, with nonpsychotic, unipolar major depression were selected. Clinical characteristics and outcomes were extracted. Outcomes were expressed as odds ratios (OR), risk differences, and weighted mean differences. RESULTS: Ten unique trials (four unpublished) with 13 contrasts met selection criteria. Trials were 6-12 weeks duration, and included 2,377 patients who received active drug and 1,788 received placebo. The ORs by meta-analysis for response and remission were 1.40 (95% confidence interval [CI] 1.24-1.57, z = 5.45, N = 13, p <0.001) and 1.27 (CI 1.12-1.44, z = 3.67, N = 13, p <0.001), respectively, with significant heterogeneity for response and remission am ... Source: www.ncbi.nlm.nih.gov --- 4 days ago
Related Articles Minor Increase in Risk of Road Traffic Accidents After Prescriptions of Antidepressants: A Study of Population Registry Data in Norway. J Clin Psychiatry. 2008 Jun 3;:e1-e5 Authors: Bramness JG, Skurtveit S, Neutel CI, Mørland J, Engeland A OBJECTIVES: Experimental studies have shown that both depression and the use of Antidepressants may impair the ability to drive a motor vehicle. Population-based studies have been inconclusive. Differences in results have been shown for cyclic, sedating antide-pressants and newer, nonsedating Antidepressants. The objective of the present study was to examine whether the use of Antidepressants by drivers increased the risk of being involved in traffic accidents. METHOD: From April 2004 to September 2006, information on prescriptions, road accidents, and emigrations/deaths was obtained from 3 Norwegian population-based registries. Data on people between the ages 18-69 (N = 3.1 million) were linked. Exposure consisted of receiving prescriptions for any anti-depressants. Standardized incidence ratios (SIRs) were calculated by comparing the incidence of accidents during time exposed with the incidence over the time not exposed. Sedating Antidepressants (tricyclic Antidepressants, mianserin, and mirtazapine) were studied together as one group, and newer, nonsedating Antidepressants (selective serotonin reuptake inhibitors, moclobemide, venlafaxine, and reboxetine) as another. RESULTS: Dur ... Source: www.springerlink.com --- 9 days ago
Abstract Bone mineral density may be negatively influenced by hyperprolactinemia, which can be caused by atypic neuroleptics and Antidepressants. Case description The present paper reports about a spontaneous rib fracture in a female patient (age 52) taking neuroleptics (mainly risperidone), Antidepressants (mainly sertraline), and anxiolytics (mainly lorazepam). At the time of the fracture a severe osteoporosis and a strongly enhanced plasma prolactin level (117 ng/ml; normal values: 3–24 ng/ml) were detected. The latter one normalized 2 months after abandoning sertraline and risperidone. After this normalization, the patient did not report further accidents up to now. Discussion Enhancement of plasma prolactin levels is linked to the mechanism of action of risperidone. Mammoplasia and increased plasma prolactin can occur during SSRI (Selective Serotonin Reuptake Inhibitors) or trazodone administration. The role of anxiolytics is less clear. The causal relationship between osteoporosis and long-term use of neuroleptics and Antidepressants was assessed using probability scores, more particularly the Naranjo probability scale and the Bradford-Hill criteria of causality. A score of 6/13 (probable) was obtained with the Naranjo scale, whereas all 9 Bradford-Hill criteria were fulfilled. Conclusion Although this case could not be fully explored, attention should be paid to bone mineral density loss in depressed patients taking a combined ... Source: www.moreover.com --- 33 days ago
University of Windsor Jun 2 2008 8:57PM GMT ... Source: www.medicalnewstoday.com --- 7 hours ago
A single antidepressant tablet makes a depressed person see the world in a more positive light just four hours after swallowing it, a new study has shown. Dr Philip Cowen, professor of pharmacology at the Department of Psychiatry at the University of Oxford, told delegates at the Royal College of Psychiatrists' Annual Meeting in London that antidepressant medication starts to work far faster than most clinicians assume. ... Source: www.physorg.com --- 18 days ago
Older people are at high risk for falls and subsequent injuries. Those who have depression have an increased risk of falls and the medications they take for depression increase their risk even more, New Zealand and Australian researchers reported in the open-access journal PLoS ONE. ... Source: www.physorg.com --- 29 days ago
As they struggle to contain skyrocketing medication costs, health plans across the U.S. have responded by implementing multi-tiered formularies requiring higher copayments for 'non-preferred' medications. New research from Brandeis University published in the Journal of Mental Health Policy and Economics suggests that the prevalent multi-tiered formulary system does impact how patients fill anti-depressant prescriptions, even though Antidepressants have certain characteristics that can make it difficult for patients to switch medications. ... Source: www.alternet.org --- 25 days ago
Mothers suffering from depression are increasingly pushed into taking pills, putting them and their infants at great risk. ... Source: www.medicalnewstoday.com --- 22 days ago
Psychiatrists have cautioned against the use of Antidepressants alone in people with bipolar disorders, saying they could worsen a patient's condition by causing a destabilisation in mood. ... Source: www.medicalnewstoday.com --- 27 days ago
As they struggle to contain skyrocketing medication costs, health plans across the U.S. have responded by implementing multi-tiered formularies requiring higher copayments for 'non-preferred' medications. ... Source: www.healthboards.com --- 1 day ago
I am a 26 year old female with Generalized Anxiety Disorder. I was diagnosed when I was 16 years old and have been on medication for it ever since. I have been on Zoloft, Celexa, and Effexor, all of which are known to have sexual side effects. Until... ... Source: psychcentral.com --- 28 days ago
Those who do not learn from history are doomed to repeat it. During the Vietnam war, the U.S. armed forces learned quite a few lessons about modern warfare the likes of which they never experienced before. One of those lessons was that fighting an intractable force on foreign soil was a frustrating effort in futility. No [...] ...
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stock photo In recent years, women have been advised to avoid medications during pregnancy and while breastfeeding their infants; yet, at the same time, some conditions pregnant women suffer such as hypertension (high blood pressure), asthma, epilepsy and depression require long-term and continued medication management. It appears as though pregnant women suffering from depression may be in a no-win situation because failure to manage depression with continued SSRI (selective serotonin reuptake inhibitor) medication may affect the health of both mother and child. SSRI's are designed to elevate the level of the neurotransmitter serotonin. A low level of serotonin is one of several neurochemical symptoms of depression. Low levels of serotonin can be caused by an anxiety disorder because serotonin is needed to metabolize stress hormones. read more ...