Anemia

Source: articles.moneycentral.msn.com --- 7 days ago
The pharmaceutical fights off rival Roche. ...

Source: articles.moneycentral.msn.com --- 4 hours ago
THOUSAND OAKS, Calif. (AP) - Biotech drugmaker Amgen Inc. said a federal court has enforced a preliminary injunction barring Roche from launching an Anemia drug that would compete against its products. ...

Source: www.ncbi.nlm.nih.gov --- 4 days ago
Related Articles Matched-related allogeneic stem cell transplantation in Saudi patients with Fanconi Anemia: 10 year's experience. Bone Marrow Transplant. 2008 Aug;42 Suppl 1:S45-S48 Authors: Ayas M, Al-Jefri A, Al-Seraihi A, Elkum N, Al-Mahr M, El-Solh H Allogeneic SCT is curative for bone marrow failure in Fanconi Anemia (FA) patients but the optimal conditioning regimen is undetermined. We report here our experience with 56 FA patients who underwent allogeneic matched related SCT. The conditioning regimen varied according to time of SCT and disease status at SCT; 22 patients (group A) received Cy 20 mg/kg, thoraco-abdominal radiation and antithymocyte globulins (ATG); and 34 patients (group B) received Cy 60 mg/kg and ATG. Median time to engraftment was similar (14 days) in both groups. Hemorrhagic cystitis was significantly more common in group B. Overall survival and event-free survival of all patients were 85 and 78.3% respectively. For groups A and B respectively, overall survival was 72.5 and 96.9% (P=0.013); and event-free survival was 72.5 and 82.3% (P=0.3). The use of the nonradiation Cy/ATG regimen in matched related SCT for FA patients offers better overall and event-free survival. PMID: 18724300 [PubMed - indexed for MEDLINE] ...

Source: www.ncbi.nlm.nih.gov --- 2 days ago
Related Articles Introduction to the Canadian Society of Nephrology clinical practice guidelines for the management of Anemia associated with chronic kidney disease. Kidney Int Suppl. 2008 Aug;(110):S1-3 Authors: Manns BJ, White CT, Madore F, Moist LM, Klarenbach SW, Barrett BJ, Foley RN, Culleton BF, Tonelli M PMID: 18668115 [PubMed - indexed for MEDLINE] ...

Source: www.ncbi.nlm.nih.gov --- 10 days ago
Related Articles Placental Characteristics in Monochorionic Twins With and Without Twin Anemia-Polycythemia Sequence. Obstet Gynecol. 2008 Oct;112(4):753-758 Authors: Lopriore E, Deprest J, Slaghekke F, Oepkes D, Middeldorp JM, Vandenbussche FP, Lewi L OBJECTIVE: To study the placental angioarchitecture of monochorionic placentas with and without twin Anemia-polycythemia sequence. METHODS: Eligible were all placentas from monochorionic twin gestations, not complicated by twin-to-twin transfusion syndrome and resulting in double survival. The study was conducted at two European Fetal Therapy Centers between 2002 and 2008. Placental angioarchitecture was evaluated using colored dye injection. Diagnosis of twin Anemia-polycythemia sequence was based on the presence of large intertwin hemoglobin difference without the degree of amniotic fluid discordance that is required for the diagnosis of twin transfusion syndrome. RESULTS: Three-hundred thirteen monochorionic twin pregnancies were eligible for the study but placental data could not be completed for 62 placentas (20%). This left 251 monochorionic twin pregnancies of which 11 (4%) fulfilled the criteria for twin Anemia-polycythemia sequence. The median number of anastomoses in monochorionic placentas with and without twin Anemia-polycythemia sequence was 3 (range: 2-5) and 7 (range: 0-25), respectively (P<.001). Small anastomoses were present in 91% (10/11) of twin Anemia-polycythemia se ...

Source: www.ncbi.nlm.nih.gov --- 10 days ago
Related Articles Recurrence of hepatitis-associated aplastic Anemia after a 10-year interval. Intern Med. 2008;47(19):1733-7 Authors: Muta T, Tanaka Y, Takeshita E, Kobayashi Y, Tokuyama T, Ueda Y, Joko K, Fujisaki T, Yokota E Hepatitis-associated aplastic Anemia (HAA) has been reported to show a successful outcome following immunosuppressive treatment. On the other hand, the long-term prognosis of HAA has not been sufficiently clarified. Herein we report a patient with HAA who had been treated with cyclosporine for one year, and maintained complete remission without treatment. Ten years later, acute non-A, non-B, and non-C hepatitis reccurred followed by bone marrow aplasia. A second immunosuppressive treatment with antithymocyte globulin and cyclosporine was effective. This case might provide useful information for the long-term follow-up of patients with HAA. PMID: 18827426 [PubMed - in process] ...

Source: www.ncbi.nlm.nih.gov --- 8 days ago
Related Articles Evaluation of Microcytic Anemia. Clin Pediatr (Phila). 2008 Oct 2; Authors: Jain S, Kamat D Anemia is deFIned as a reduction in red blood cell mass or hemoglobin concentration in blood. It is statistically differentiated from normal states as a hemoglobin concentration or hematocrit 2 SD below the mean for the healthy population adjusted for age and sex. Anemias may be classiFIed based on the morphologic function of red blood cells and their size on a peripheral blood smear. Subcategories are microcytic, normocytic, and macrocytic anemias, but these are not mutually exclusive. In infants and children, the most common form of Anemia is microcytic. A detailed history and physical examination with appropriate laboratory test results can help detect the correct cause of Anemia in most patients. The objective of this article is to aid physicians taking care of children in conducting a proper evaluation to identify the correct cause of microcytic Anemia. PMID: 18832550 [PubMed - as supplied by publisher] ...

Source: www.ncbi.nlm.nih.gov --- 2 days ago
[Apoptosis induction and phosphorylated protein kinase Cepsilone expression in 32D cells by sera from patients with aplastic Anemia] Zhonghua Xue Ye Xue Za Zhi. 2008 May;29(5):296-9 Authors: Sheng Y, Liu H, Xu MY, Jiang SH, Ding RS, Lu W OBJECTIVE: To investigate the effect of phosphorylated protein kinase Cepsilon (pPKCepsilon) on apoptosis of 32D cells induced by sera from patients with aplastic Anemia (AA). METHODS: The expression of pPKCepsilon and apoptosis in 32D cells were measured by Western blotting and flow cytometry after incubation with sera from healthy individuals (controls, n = 8), patients with severe AA ( SAA, n = 8)and non severe AA (NSAA, n = 6). RESULTS: After incubation for 0, 12, 24, 36 and 48 hours in the presence of serum and for another 4 hours in medium deprived of serum, the levels of pPKCepsilon in cells in SAA and NSAA group increased gradually, peaked at 24 hours, and then declined (P < 0.05). Compared with that in control group (0.54 +/- 0.08), pPKCepsilon was overexpressed in both SAA group (0.90 +/- 0.10) and NSAA group (0.64 +/- 0.08) (P < 0.05) after 24 hours incubation with serum and subsequent 4 hours without serum. pPKCepsilon level was higher in SAA group than in NSAA group (P < 0.05). A greater proportion of 32D cells showed apoptosis after 24 hours incubation with sera from SAA patients [(4.05 +/- 1.05)%] and subsequent 4 hours incubation without serum than that in controls [(2.45 +/- 0.51)%, ...

Source: www.ncbi.nlm.nih.gov --- 21 hours ago
Related Articles Methoxypolyethylene glycol-epoetin beta for the treatment of Anemia associated with chronic kidney disease. Drugs Today (Barc). 2008 Aug;44(8):577-84 Authors: Del Vecchio L, Cavalli A, Locatelli F Therapy with erythropoiesis-stimulating agents (ESAs) is a well-established treatment for renal Anemia. ESAs are highly effective at correcting the underlying Anemia, restoring energy levels and increasing patient well-being and quality of life. Anemia correction has considerable secondary benefits in terms of morbidity and mortality reduction. However, because of the relatively short halflife of ESAs, they generally have to be administered one to three times weekly in most patients. In order to overcome this shortcoming, in recent years pharmacological research has tried to modify the molecular structure of recombinant human erythropoietin (rHuEpo) in order to improve pharmacokinetics and pharmacodynamics and to allow a reduction in the frequency of administration. Covalent addition of the water-soluble polyethylene glycol moiety has been successfully used to improve the pharmacokinetics of a number of proteins and reduce their immunogenicity. A modified version of rHuEPO incorporating this large polymer chain, called continuous erythropoiesis receptor activator (CERA), has been recently synthesized. Data from animal studies indicate that CERA has a prolonged half-life in comparison with rHuEPO that may allow less frequent ...

Source: www.ncbi.nlm.nih.gov --- 5 days ago
Related Articles Colonic lymphangiomatosis associated with Anemia. World J Gastroenterol. 2008 Oct 7;14(37):5760-2 Authors: Chung WC, Kim HK, Yoo JY, Lee JR, Lee KM, Paik CN, Jang UI, Yang JM Lymphangioma is an uncommon malformation of lymphatic system. Multiple colonic lymphangioma named as lymphangiomatosis is considered an extremely rare disease. Although lymphangioma is a benign tumor and most colonic lymphangiomas do not cause symptoms and do not require treatment, resection of lymphangioma is necessary in the presence of symptoms such as abdominal pain, bleeding, intussusceptions. We report a case of colonic lymphangiomatosis in a man who presented with abdominal discomfort and Anemia, which was diagnosed and treated with endoscopic snare polypectomy. PMID: 18837097 [PubMed - in process] ...

Source: www.ncbi.nlm.nih.gov --- 5 days ago
Related Articles Aplastic Anemia presenting as spontaneous orbital hemorrhage. Orbit. 2008;27(5):391-3 Authors: Grové JD, Meyer D We report a case of a 51-year-old female presenting with a three-day history of a painful swollen right eye associated with loss of vision. She presented with no light perception in the affected eye, periocular ecchymosis, hemorrhagic chemosis, and an axial proptosis. CT scan revealed a unilateral proptosis with tension on the optic nerve and accompanying diffuse retrobulbar hemorrhage. Bone marrow studies confirmed aplastic Anemia. A review of the English literature failed to reveal previous cases of aplastic Anemia presenting with spontaneous orbital hemorrhage. We suggest that aplastic Anemia be included in the differential diagnosis of a patient presenting with painful spontaneous orbital hemorrhage. PMID: 18836941 [PubMed - in process] ...

Source: www.ncbi.nlm.nih.gov --- 12 days ago
Treatment with Infliximab plus Methotrexate Improves Anemia in Patients with Rheumatoid Arthritis Independent of Improvement in Other Clinical Outcome Measures-A Pooled Analysis from Three Large, Multicenter, Double-Blind, Randomized Clinical Trials. Semin Arthritis Rheum. 2008 Sep 25; Authors: Doyle MK, Rahman MU, Han C, Han J, Giles J, Bingham Iii C, Bathon J OBJECTIVE: To evaluate the effect of antitumor necrosis factor-alpha monoclonal antibody infliximab treatment on Anemia in rheumatoid arthritis (RA) patients. METHODS: Data from RA patients who received infliximab or placebo in the multicenter, placebo-controlled, double-blind, randomized ATTRACT, ASPIRE, and START studies were included in this post-hoc, pooled analysis. Infliximab (3 to 10 mg/kg) was administered every 4 or 8 weeks, and all patients received stable doses of methotrexate (MTX). We determined the percentage of anemic patients (baseline hemoglobin level <12 g/dL) who had an increase from baseline in hemoglobin level greater than or equal to 1 or 2 g/dL or achieved normal hemoglobin levels at week 22. The association of improvement in Anemia with improvement in clinical parameters was also evaluated. RESULTS: Among patients with Anemia at baseline, infliximab plus MTX treatment produced a significantly greater mean (standard deviation) increase in hemoglobin levels from baseline to week 22 (0.74 [1.12], P < 0.0001) than placebo plus MTX (0.30 [0.92]). Significantly ...

Source: www.ncbi.nlm.nih.gov --- 3 days ago
Related Articles Maternal Anemia, iron intake in pregnancy, and offspring blood pressure in the Avon Longitudinal Study of Parents and Children. Am J Clin Nutr. 2008 Oct;88(4):1126-33 Authors: Brion MJ, Leary SD, Smith GD, McArdle HJ, Ness AR BACKGROUND: In animals, maternal iron deficiency during pregnancy results in elevated offspring blood pressure (BP). Studies in pregnant women are limited in number, have had inconsistent results, and have not accounted for maternal iron supplementation. OBJECTIVE: The objective was to assess the association between maternal iron status during pregnancy and offspring BP. DESIGN: Maternal hemoglobin (n = 1255), iron supplementation (n = 7484), food-based iron intake (n = 7130), and offspring BP were assessed in a prospective cohort at 7 y of age. RESULTS: Maternal Anemia during pregnancy was associated with lower systolic BP in the offspring at 7 y of age (third trimester, age- and sex-adjusted: beta = -1.09; 95% CI: -2.21, -0.05 mm Hg; P = 0.04). Adjustment for confounders attenuated this association (beta = -0.49; 95% CI: -1.71, 0.72 mm Hg; P = 0.4). In women who did not take iron supplements during pregnancy, the observed association with maternal Anemia was even stronger: minimally adjusted models (beta = -2.11; 95% CI: -3.61, -0.61 mm Hg; P = 0.006) and fully adjusted models (beta = -1.48; 95% CI: -3.21, 0.25 mm Hg; P = 0.09). Iron supplementation was not associated with offspring BP after c ...

Source: www.ncbi.nlm.nih.gov --- 8 days ago
Related Articles Head and neck squamous cell carcinoma in 13 patients with Fanconi Anemia after hematopoietic stem cell transplantation. Cancer. 2008 Oct 2; Authors: Masserot C, Peffault de Latour R, Rocha V, Leblanc T, Rigolet A, Pascal F, Janin A, Soulier J, Gluckman E, Socié G BACKGROUND.: Fanconi Anemia (FA) is a chromosomal instability disorder with a very high risk of developing head and neck squamous cell carcinoma (HNSCC), most notably after hematopoietic stem cell transplantation (HSCT). METHODS.: In the current study, the authors reported 13 cases of HNSCC in FA patients who underwent HSCT at the Saint Louis Hospital between 1976 and 2007. RESULTS.: The median age of the patients at time of HSCT was 9.7 years. All patients received irradiation-based conditioning before HSCT and all developed extensive chronic graft versus host disease (GVHD). HNSCC was diagnosed at a median interval of 10 years after HSCT, mainly in numerous sites within the oral cavity (11 patients). Lymph node involvement was diagnosed in 4 patients. The TNM classification was: T1 in 6 patients, T2 in 2 patients, T3 in 2 patients, and T4 in 3 patients. Treatment was comprised of surgery in 10 patients, with clear surgical margins reported in 7 (including cervical lymph node dissection in 6 patients). Surgery was performed in addition to other treatments in only 2 patients (radiotherapy or cryotherapy). For the remaining 3 patients, treatment consisted in r ...

Source: www.ncbi.nlm.nih.gov --- 21 hours ago
Related Articles Intravenous Versus Oral Iron Supplementation for the Treatment of Anemia in CKD: Systematic Review and Meta-analysis. Am J Kidney Dis. 2008 Oct 7; Authors: Rozen-Zvi B, Gafter-Gvili A, Paul M, Leibovici L, Shpilberg O, Gafter U BACKGROUND: Iron supplementation is essential for the treatment of patients with Anemia of chronic kidney disease (CKD). It is not clear which is the best method of iron administration. STUDY DESIGN: Systematic review and meta-analysis. A search was performed until January 2008 of MEDLINE, Cochrane Central Register of Controlled Trials, conference proceedings in nephrology, and reference lists of included trials. SETTING & POPULATION: Patients with CKD (stages III to V). We included dialysis patients and patients with CKD not on dialysis therapy (hereafter referred to as patients with CKD). SELECTION CRITERIA FOR STUDIES: We included all randomized controlled trials regardless of publication status or language. INTERVENTION: Intravenous (IV) versus oral iron supplementation. OUTCOMES MEASURES: Primary outcomes assessed: absolute hemoglobin (Hb) level or change in Hb level from baseline. We also assessed all-cause mortality, erythropoiesis-stimulating agent requirement, adverse events, ferritin level, and need for renal replacement therapy in patients with CKD. RESULTS: 13 trials were identified, 6 including patients with CKD and 7 including dialysis patients. Compared with oral iron, there was ...

Source: www.ncbi.nlm.nih.gov --- 8 days ago
Related Articles [Anemia as a public health problem: the current situation] Cien Saude Colet. 2008 Nov-Dec;13(6):1917-22 Authors: Batista Filho M, de Souza AI, Bresani CC In 1990, the United Nations held a World Summit in New York, in which goals for the upcoming decade were established. One of these goals was a one-third reduction in the prevalence of Anemia among women at childbearing age. Despite this modest percentage, epidemiological indicators point to the opposite direction, indicating an increasing occurrence of Anemia in different regions of the world, including in Brazil. These data show that Anemia has continued since the antiquity to be one of the most prevalent and widespread diseases in human populations. Thus, a number of questions without answers arise regarding the actual prevalence and etiopathogenesis of the problem as well as with respect to the degree of implantation and the effectiveness of control measures. PMID: 18833369 [PubMed - in process] ...

Source: blogs.wsj.com --- 10 days ago
A federal court finally prohibited Roche from sell its drug Mircera in the U.S. The drug would have competed with Amgen's Epogen and Aranesp. ...

Source: www.associatedcontent.com --- 25 days ago
Anemia or a lack of iron can be treated by eating these foods ...

Source: www.moreover.com --- 10 days ago
Drug Store News Oct 3 2008 7:39PM GMT ...

Source: www.healthboards.com --- 11 hours ago
Hi and thanks for reading my posting. I was recently diagnosed with Pernicious Anemia and since have been going for B12 injections. My doc has me doing the shots once a month. I have been going each month for the past 6 months. So far, my B12... ...