Alzheimer

Source: www.ncbi.nlm.nih.gov --- 2 hours ago
Related Articles Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron. 2008 Jun 26;58(6):871-83 Authors: Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK Mutations in presenilins (PS) are the major cause of familial Alzheimer's disease (FAD) and have been associated with calcium (Ca2+) signaling abnormalities. Here, we demonstrate that FAD mutant PS1 (M146L)and PS2 (N141I) interact with the inositol 1,4,5-trisphosphate receptor (InsP3R) Ca2+ release channel and exert profound stimulatory effects on its gating activity in response to saturating and suboptimal levels of InsP3. These interactions result in exaggerated cellular Ca2+ signaling in response to agonist stimulation as well as enhanced low-level Ca2+signaling in unstimulated cells. Parallel studies in InsP3R-expressing and -deficient cells revealed that enhanced Ca2+ release from the endoplasmic reticulum as a result of the specific interaction of PS1-M146L with the InsP3R stimulates amyloid beta processing,an important feature of AD pathology. These observations provide molecular insights into the "Ca2+ dysregulation" hypothesis of AD pathogenesis and suggest novel targets for therapeutic intervention. PMID: 18579078 [PubMed - indexed for MEDLINE] ...

Source: www.ncbi.nlm.nih.gov --- 20 hours ago
Related Articles PPARs in Alzheimer's Disease. PPAR Res. 2008;2008:403896 Authors: Kummer MP, Heneka MT Peroxisome proliferator-activated receptors (PPARs) are well studied for their peripheral physiological and pathological impact, but they also play an important role for the pathogenesis of various disorders of the central nervous system (CNS) like multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's, and Parkinson's disease. The observation that PPARs are able to suppress the inflammatory response in peripheral macrophages and in several models of human autoimmune diseases lead to the idea that PPARs might be beneficial for CNS disorders possessing an inflammatory component. The neuroinflammatory response during the course of Alzheimer's disease (AD) is triggered by the neurodegeneration and the deposition of the beta-amyloid peptide in extracellular plaques. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been considered to delay the onset and reduce the risk to develop Alzheimer's disease, while they also directly activate PPARgamma. This led to the hypothesis that NSAID protection in AD may be partly mediated by PPARgamma. Several lines of evidence have supported this hypothesis, using AD-related transgenic cellular and animal models. Stimulation of PPARgamma receptors by synthetic agonist (thiazolidinediones) inducing anti-inflammatory, anti-amyloidogenic, and insulin sensitising effects may account for the observed ...

Source: hms.harvard.edu --- 1 day ago
A recent study provides insight into how Alzheimer’s disease begins, and how it might be treated. More topics at Alzheimer's disease Additional disease-related research news at Consumer information ...

Source: www.medicinenet.com --- 15 hours ago
Title: Alzheimer's Research Brings Progress, Setbacks Category: Health News Created: 7/19/2008 2:00:00 AM Last Editorial Review: 7/21/2008 ...

Source: blog.beliefnet.com --- 11 hours ago
Gledhill reports on an address a Roman Catholic cardinal gave to the Lambeth conference, in which he chastised certain sections of the Communion for having "spiritual Alzheimer's." Excerpt from the cardinal's speech: '"Much is spoken today of diseases like Alzheimer's... ...

Source: www.newscientist.com --- 18 hours ago
An abandoned antihistimine is found to improve cognitive ability, while a vaccine that helps destroy plaques did not alleviate symptoms ...

Source: www.moreover.com --- 2 hours ago
News-Medical.Net Jul 24 2008 3:27AM GMT ...

Source: www.moreover.com --- 3 hours ago
Immune Support Jul 24 2008 6:54AM GMT ...

Source: www.moreover.com --- 2 hours ago
The Open Press Jul 24 2008 4:25AM GMT ...

Source: www.moreover.com --- 2 hours ago
Irish Examiner Jul 24 2008 3:04AM GMT ...

Source: www.moreover.com --- 2 hours ago
Science Daily Jul 24 2008 1:37AM GMT ...

Source: www.moreover.com --- 2 hours ago
Corante Jul 24 2008 4:52AM GMT ...

Source: cbs2chicago.com --- 14 hours ago
Eye On Health: epilepsy drug warning, arthritis drugs and Alzheimer's, cranberry juice and infections, tattoo removal. ...

Source: www.centredaily.com --- 44 minutes ago
EPIX Pharmaceuticals, Inc. (NASDAQ:EPIX), a biopharmaceutical company focused on discovering and developing novel therapeutics through the use of its proprietary and highly efficient in silico drug discovery platform, today announced that it is scheduled to make two presentations at the 2008 Alzheimer's Association International Conference on Alzheimer's Disease in Chicago. ...

Source: www.medpagetoday.com --- 23 hours ago
LOS ANGELES -- Language skills lost to Alzheimer's disease may be regained with perispinal infusions of the anti-inflammatory drug etanercept (Enbrel), researchers said. ...

Source: www.islandpacket.com --- 23 hours ago
Alzheimer's Respite & Resource will host a culinary event, "M... M... M... GOOD!", at 6:30 p.m. Tuesday at the Sea Pines Country Club. ...

Source: mythoughtsideasandramblings.com --- 1 day ago
document.write('‘); As many of you may know, the Alzheimer Association is a cause that is near and dear to my heart. I know too many people that have had such a horrible disease. It truly steals who you are right out from underneath you. My mom figures that her [...] ...

Source: www.vvdailypress.com --- 9 hours ago
VICTORVILLE — The waiting room at St. ...

Source: cbs4.com --- 1 day ago
It's estimated some five million Americans have Alzheimer's disease. That number is expected to rise in the coming years as our population ages. Scientists around the world are trying to develop drugs to combat the illness and now a new vaccine is showing some benefit. ...