Publication Date: 2008 PMID: 18628745 Authors: Martin, F. P. - Wang, Y. - Sprenger, N. - Yap, I. K. - Rezzi, S. - Ramadan, Z. - Pere-Trepat, E. - Rochat, F. - Cherbut, C. - van Bladeren, P. - Fay, L. B. - Kochhar, S. - Lindon, J. C. - Holmes, E. - Nicholson, J. K. Journal: Mol Syst Biol Gut microbiome-host metabolic interactions affect human health and can be modified by probiotic and prebiotic supplementation. Here, we have assessed the effects of consumption of a combination of probiotics (Lactobacillus paracasei or L. rhamnosus) and two galactosyl-oligosaccharide prebiotics on the symbiotic microbiome-mammalian supersystem using integrative metabolic profiling and modeling of multiple compartments in germ-free mice inoculated with a model of human baby microbiota. We have shown specific impacts of two prebiotics on the microbial populations of HBM mice when co-administered with two probiotics. We observed an increase in the populations of Bifidobacterium longum and B. breve, and a reduction in Clostridium perfringens, which were more marked when combining prebiotics with L. rhamnosus. In turn, these microbial effects were associated with modulation of a range of host metabolic pathways observed via changes in lipid profiles, gluconeogenesis, and amino-acid and methylamine metabolism associated to fermentation of carbohydrates by different bacterial strains. These results provide evidence for the potential use of prebiotics for bene ...
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