Related Articles Lymphocyte DNA damage and total antioxidant status in patients with white-coat hypertension and sustained hypertension. Turk Kardiyol Dern Ars. 2008;36(4):231-238 Authors: Yıldız A, Gür M, Yılmaz R, Demirbağ R, Celik H, Aslan M, Koçyiğit A OBJECTIVES: We assessed lymphocyte DNA damage and total antioxidant status (TAS) in patients with white-coat hypertension (WCH) and sustained hypertension (SHT). STUDY DESIGN: The study included 23 patients (14 females, 9 males; mean age 46+/-6 years) with WCH, 21 patients (13 females, 8 males; mean age 45+/-7 years) with newly diagnosed SHT, and 19 age- and sex-matched healthy volunteers as controls. All subjects underwent echocardiographic examination, office blood pressure measurements, and 24-hour ambulatory blood pressure monitoring. DNA damage was assessed by the alkaline comet assay in peripheral lymphocytes, and plasma TAS levels were determined using an automated measurement method. RESULTS: The two hypertensive groups had similar echocardiographic measurements and office systolic and diastolic blood pressures. The mean daytime and nighttime pressures were significantly higher in the SHT group (p<0.05). Patients with WCH had similar daytime and nighttime pressures compared to the controls (p>0.05). Patients with SHT had significantly increased lymphocyte DNA damage (p<0.001, for both WCH and control groups) and decreased TAS level (p=0.012 vs WCH group; p<0.001 vs controls). ...
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