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 7/10 Very Good --- www.boston.com http://www.boston.com/business/ticker/index.rdf
Tuesday, June 24, 2008 --- 66 days ago http://www.boston.com/business/ticker/2008/06/genzyme_and_isi.html
| Genzyme Corp. and Isis Pharmaceuticals Inc. said today that they finalized their agreement to give Genzyme exclusive rights to mipomersen, a cholesterol drug candidate discovered and developed by Isis. Under original terms of the deal, first announced in January, Genzyme of Cambridge bought five million Isis shares for $150 million and agreed to pay Isis a $175 million upfront license fee. The companies now say California-based Isis will contribute up to $50 million in additional development funding for mipomersen, bringing the company's funding commitment up to $125 million. After that, Isis and Genzyme will share development costs equally. In exchange for the additional contribution, Isis may receive $75 million in milestone payments early. Mipomersen is currently in late-stage trials to treat patients with homozygous familial hypercholesterolemia, a severe form of high cholesterol. The companies expect to apply with the Food and Drug Administration in the second half of 2010 for approval, and will approach regulatory authorities in Europe. The companies said other financial terms are unchanged under the final agreement. Isis is eligible to receive up to $750 million in commercial milestone payments and up to $825 million in development and regulatory milestone fees. Genzyme and Isis will share mipomersen profits on a sliding scale. The split will be 50/50 when annual revenue reaches $2 billion. As part of the relationship, Genzyme ... |
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