Related Articles Flow induced by acoustic streaming on surface-acoustic-wave devices and its application in biofouling removal: A computational study and comparisons to experiment. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Jun;77(6 Pt 2):066308 Authors: Sankaranarayanan SK, Cular S, Bhethanabotla VR, Joseph B All transducers used in biological sensing suffer from fouling resulting from nonspecific binding of protein molecules to the device surface. The acoustic-streaming phenomenon, which results from the fluid motion induced by high-intensity sound waves, can be used to remove these nonspecifically bound proteins to allow more accurate determinations and reuse of these devices. We present a computational and experimental study of the acoustic-streaming phenomenon induced by surface acoustic waves.A coupled-field fluid-structure interaction (FSI) model of a surface-acoustic-wave (SAW) device based on a micrometer-sized piezoelectric substrate (YZ-LiNbO3) in contact with a liquid loading was developed to study the surface-acoustic-wave interaction with fluid loading. The fluid domain was modeled using the Navier-Stokes equation; the arbitrary Lagrangian-Eulerian approach was employed to handle the mesh distortions arising from the motion of the solid substrate. The fluid-solid coupling was established by maintaining stress and displacement continuity at the fluid-structure interface. A transient analysis was carried out by applying ...