This study aims at characterizing and modelling the effect of mechanical factors on endothelial denudation during angioplasty, such as normal force between balloon and artery, stretching of arterial walls, and relative displacement between contacting surfaces. Friction damage was applied to porcine aorta samples with different contact forces, relative displacements, and biplanar stretching conditions. After the tests, endothelium denudation was quantified by isolating and counting the remaining endothelial cells. Using multiple-regression analysis, a constitutive model is proposed for integration in finite element software. This model will help optimize balloon and stent deployment conditions to minimize the amount of damage to the endothelium, and eventually to reduce the occurrence of restenosis. Content Type Book Chapter DOI 10.1007/978-3-540-70521-5_3 Authors Sébastien Delorme, Industrial Materials Institute 75 de Mortagne Blvd Boucherville QC J4B 6Y4 Canada Rouwayda El-Ayoubi, Industrial Materials Institute 75 de Mortagne Blvd Boucherville QC J4B 6Y4 Canada Patricia Debergue, Industrial Materials Institute 75 de Mortagne Blvd Boucherville QC J4B 6Y4 Canada Book Series Lecture Notes in Computer Science Online ISSN 1611-3349 Print ISSN 0302-9743 Book Series Volume Volume 5104/2008 Book Biomedical Simulation DOI 10.1007/978-3-540-70521-5 Print ISBN 978-3-540-70520-8 ...
Anytime
