Related Articles Androgens May Mediate a Relative Preservation of IGF-1 Levels in Overweight and Obese Women Despite Reduced Growth Hormone Secretion. J Clin Endocrinol Metab. 2008 Jul 22; Authors: Utz A, Yamamoto A, Sluss P, Breu J, Miller KK Context: Obesity is characterized by reduced GH secretion, but data regarding IGF-1 levels and their determinants are conflicting. Objective: To determine whether IGF-1 levels are reduced and to investigate determinants of GH and IGF-1 in healthy overweight and obese women Design: Cross-sectional Setting: General Clinical Research Center Study Participants: 34 healthy women without pituitary/hypothalamic disease: 11 lean (BMI < 25 kg/m(2)), 12 overweight (BMI >/= 25 kg/m(2) and < 30 kg/m(2)) and 11 obese (>/= 30 kg/m(2)) women of comparable age (overall mean 30.7 +/- 7.8 y). Intervention: None Main Outcome Measures: 24-h q 10 minute frequent sampling for GH, peak GH after GHRH-arginine stimulation, IGF-1, IGFBP-3, estrone, estradiol, testosterone, free testosterone, SHBG, HOMA-IR and abdominal fat. Results: Mean 24-hour GH and peak stimulated GH were lower in overweight than lean and lowest in obese women. Mean IGF-1 levels trended lower in obese, but not overweight, compared with lean, women. Free testosterone was positively associated with IGF-1 (R=0.36, p=0.04) but not with GH measures. Visceral fat was the only determinant of mean 24-hour GH (R(2)=0.66, p<0.0001) and of peak stimulated GH (R ...
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