 8/10 Excellent --- eutils.ncbi.nlm.nih.gov http://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=0EG9mRQ3CCbOeoP4n
| NCBI: db=PubMed; Term=adiponectin[title word] ... |
Friday, July 04, 2008 --- 150 days ago http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&a
| Adiponectin and Risk of Coronary Heart Disease in Older Men and Women. J Clin Endocrinol Metab. 2008 Jul 1; Authors: Kizer JR, Barzilay JI, Kuller LH, Gottdiener JS Context: Despite established insulin-sensitizing and anti-atherogenic preclinical effects, epidemiological investigations of adiponectin have yielded conflicting findings, and its relationship with coronary heart disease (CHD) remains uncertain. Objective: To investigate the relationship between adiponectin and CHD in older adults. Design, Setting, and Participants: Case-control study (N=1,386) nested within the population-based Cardiovascular Health Study from 1992 to 2001. Controls were frequency-matched to cases by age, sex, race, subclinical cardiovascular disease and center. Main Outcome Measures: Incident CHD was defined as angina pectoris, percutaneous or surgical revascularization, non-fatal myocardial infarction (MI) or CHD death. A more restrictive CHD endpoint was limited to non-fatal MI and CHD death. Results: Adiponectin exhibited significant negative correlations with baseline adiposity, insulin resistance, dyslipidemia, inflammatory markers, and leptin. After controlling for matching factors, adjustment for waist-hip ratio, hypertension, smoking, alcohol, LDL-cholesterol, creatinine, and leptin revealed a modestly increased risk of incident CHD with adiponectin concentrations at the upper end (OR= 1.37 [Quintile 5 vs. 1-4], 95% CI=1.02-1.84). This association ... |
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