Over 30 years ago, Fox Chase Cancer Center's Alfred Knudson, Jr., revolutionized cancer genetics with the Two-Hit Hypothesis, which guided scientists around the globe in their quest for tumor suppressor genes. Now, Knudson and colleagues offer evidence that a "one-hit" event is enough to make cells abnormal. By studying the first colon cell proteome, which describes the proteins a cell makes, they believe they may have discovered patterns that could indicate cancer. ...
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